Change search
Link to record
Permanent link

Direct link
BETA
van der Wijngaart, WouterORCID iD iconorcid.org/0000-0001-8248-6670
Alternative names
Publications (10 of 172) Show all publications
da Silva Granja, G., Sandström, N., Efimov, I., Ostanin, V. P., van der Wijngaart, W., Klenerman, D. & Ghosh, S. (2018). Characterisation of particle-surface interactions via anharmonic acoustic transduction. Sensors and actuators. B, Chemical, 272, 175-184
Open this publication in new window or tab >>Characterisation of particle-surface interactions via anharmonic acoustic transduction
Show others...
2018 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 272, p. 175-184Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2018
National Category
Nano Technology
Identifiers
urn:nbn:se:kth:diva-235182 (URN)10.1016/j.snb.2018.05.016 (DOI)000439715000023 ()2-s2.0-85048499666 (Scopus ID)
Projects
Norosensor
Note

QC 20181003

Available from: 2018-09-17 Created: 2018-09-17 Last updated: 2018-10-03Bibliographically approved
van der Wijngaart, W. (2018). Characterisation of particle-surface interactions via anharmonic acoustic transduction. Sensors and actuators. B, Chemical, 272
Open this publication in new window or tab >>Characterisation of particle-surface interactions via anharmonic acoustic transduction
2018 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 272Article in journal (Refereed) Published
National Category
Engineering and Technology
Identifiers
urn:nbn:se:kth:diva-238752 (URN)10.1016/j.snb.2018.05.016 (DOI)
Available from: 2018-11-09 Created: 2018-11-09 Last updated: 2018-11-09
Iseri, E., Akay, S. & van der Wijngaart, W. (2018). Detection of E.coli in a digital assay. In: 2018 IEEE Micro Electro Mechanical Systems (MEMS): . Paper presented at 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, United Kingdom, 21 January 2018 through 25 January 2018 (pp. 301-303). Institute of Electrical and Electronics Engineers (IEEE)
Open this publication in new window or tab >>Detection of E.coli in a digital assay
2018 (English)In: 2018 IEEE Micro Electro Mechanical Systems (MEMS), Institute of Electrical and Electronics Engineers (IEEE), 2018, p. 301-303Conference paper, Published paper (Refereed)
Abstract [en]

In this paper, we demonstrate the dipstick-based digitisation and detection of bacterial sample of concentration down to 103 CFU/ml. The significance of this work is that we are able to detect concentrations of bacteria relevant for urinary tract infection (UTI) with minimal handling time and without the need for complicated external equipment.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2018
Series
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), ISSN 1084-6999
National Category
Microbiology in the medical area
Identifiers
urn:nbn:se:kth:diva-228551 (URN)10.1109/MEMSYS.2018.8346545 (DOI)000434960900080 ()2-s2.0-85047007412 (Scopus ID)9781538647820 (ISBN)
Conference
31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, United Kingdom, 21 January 2018 through 25 January 2018
Funder
EU, Horizon 2020, 675412
Note

QC 20180528

Available from: 2018-05-28 Created: 2018-05-28 Last updated: 2018-09-05Bibliographically approved
Yasuga, H., Guo, W., Hansson, J., Haraldsson, T., Miki, N. & van der Wijngaart, W. (2018). Droplet microfluidics inside paper. In: 2018 IEEE Micro Electro Mechanical Systems (MEMS): . Paper presented at 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, United Kingdom, 21 January 2018 through 25 January 2018 (pp. 269-271). Institute of Electrical and Electronics Engineers (IEEE)
Open this publication in new window or tab >>Droplet microfluidics inside paper
Show others...
2018 (English)In: 2018 IEEE Micro Electro Mechanical Systems (MEMS), Institute of Electrical and Electronics Engineers (IEEE), 2018, p. 269-271Conference paper, Published paper (Refereed)
Abstract [en]

Here, we demonstrate, for the first time: the self-digitization, i.e. spontaneous formation, of microdroplets during the imbibition of paper; the on-demand merging of individual microdroplets in paper; and the on-demand ejection of individual microdroplets from the paper. Two technical novelties underlie these novel functions: the formation of free-standing synthetic microfluidic paper, i.e. a porous matrix of slanted and interconnected micropillars without bottom layer; and the hydrophobic surface modification of the paper. The ease of manipulation and the direct access to the microdroplets from the environment makes this an extremely versatile tool, with potential applications in liquid sample digitisation and microparticle generation.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2018
National Category
Other Engineering and Technologies not elsewhere specified
Identifiers
urn:nbn:se:kth:diva-228552 (URN)10.1109/MEMSYS.2018.8346536 (DOI)000434960900071 ()2-s2.0-85047016277 (Scopus ID)9781538647820 (ISBN)
Conference
31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, United Kingdom, 21 January 2018 through 25 January 2018
Note

QC 20180528

Available from: 2018-05-28 Created: 2018-05-28 Last updated: 2018-09-05Bibliographically approved
van der Wijngaart, W. (2018). E-Beam Nanostructuring and Direct Click Biofunctionalization of Thiol–Ene Resist. ACS Nano
Open this publication in new window or tab >>E-Beam Nanostructuring and Direct Click Biofunctionalization of Thiol–Ene Resist
Show others...
2018 (English)In: ACS Nano, ISSN 1936-0851, E-ISSN 1936-086XArticle in journal (Refereed) Published
Keywords
OSTE; biohybrid; e-beam; nanoscale; NEMS; protein patterning; resist; thiol−ene
National Category
Nano Technology
Identifiers
urn:nbn:se:kth:diva-236089 (URN)10.1021/acsnano.8b03709 (DOI)000448751800030 ()
Note

QC 20181114

Available from: 2018-10-16 Created: 2018-10-16 Last updated: 2018-11-14Bibliographically approved
Guo, M., Hernández-Neuta, I., Madaboosi, N., Nilsson, M. & van der Wijngaart, W. (2018). Efficient DNA-assisted synthesis of trans-membrane gold nanowires. Microsystems & Nanoengineering, 4, 1-8, Article ID UNSP 17084.
Open this publication in new window or tab >>Efficient DNA-assisted synthesis of trans-membrane gold nanowires
Show others...
2018 (English)In: Microsystems & Nanoengineering, ISSN 2055-7434, Vol. 4, p. 1-8, article id UNSP 17084Article in journal (Refereed) Published
Abstract [en]

Whereas electric circuits and surface-based (bio)chemical sensors are mostly constructed in-plane due to ease of manufacturing, 3D microscale and nanoscale structures allow denser integration of electronic components and improved mass transport of the analyte to (bio)chemical sensor surfaces. This work reports the first out-of-plane metallic nanowire formation based on stretching of DNA through a porous membrane. We use rolling circle amplification (RCA) to generate long single-stranded DNA concatemers with one end anchored to the surface. The DNA strands are stretched through the pores in the membrane during liquid removal by forced convection. Because the liquid–air interface movement across the membrane occurs in every pore, DNA stretching across the membrane is highly efficient. The stretched DNA molecules are transformed into trans-membrane gold nanowires through gold nanoparticle hybridization and gold enhancement chemistry. A 50 fM oligonucleotide concentration, a value two orders of magnitude lower than previously reported for flat surface-based nanowire formation, was sufficient for nanowire formation. We observed nanowires in up to 2.7% of the membrane pores, leading to an across-membrane electrical conductivity reduction from open circuit to o20 Ω. The simple electrical read-out offers a high signal-to-noise ratio and can also be extended for use as a biosensor due to the high specificity and scope for multiplexing offered by RCA.

National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
urn:nbn:se:kth:diva-227196 (URN)10.1038/micronano.2017.84 (DOI)000425451300001 ()
Funder
Swedish Research Council, SBE13-0125Swedish Foundation for Strategic Research , SBE13-0125EU, Horizon 2020, 675412
Note

Correction in: Microsystems & Nanoengineering (2018) 4:9 DOI: 10.1038/s41378-018-0012-7, WOS: 000434457800001

QC 20180601

Available from: 2018-05-04 Created: 2018-05-04 Last updated: 2018-09-18Bibliographically approved
Guo, W., Gustafsson, L., Jansson, R., Hedhammar, M. & van der Wijngaart, W. (2018). Formation of a thin-walled Spider Silk Tube on a Micromachined Scaffold. In: Proceeding of 2018 IEEE 31st International Conference on Micro Electro Mechanical Systems (MEMS): . Paper presented at 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, United Kingdom, 21 January 2018 through 25 January 2018 (pp. 83-85). Institute of Electrical and Electronics Engineers (IEEE), 2018
Open this publication in new window or tab >>Formation of a thin-walled Spider Silk Tube on a Micromachined Scaffold
Show others...
2018 (English)In: Proceeding of 2018 IEEE 31st International Conference on Micro Electro Mechanical Systems (MEMS), Institute of Electrical and Electronics Engineers (IEEE), 2018, Vol. 2018, p. 83-85Conference paper, Published paper (Refereed)
Abstract [en]

This paper reports on the first formation of a thin bio-functionalized spider silk tube, supported by an internal micromachined scaffold, in which both the inside and outside of the tube wall are freely accessible. The silk tube could potentially be used as an artificial blood vessel in an in vitro tissue scaffold, where endothelial cells and tissue cells can grow on both sides of the silk tube.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2018
Series
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), ISSN 1084-6999
Keywords
spider silk, tissue engineering, artificial blood vessel
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:kth:diva-225863 (URN)10.1109/MEMSYS.2018.8346488 (DOI)2-s2.0-85047021023 (Scopus ID)9781538647820 (ISBN)
Conference
31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, United Kingdom, 21 January 2018 through 25 January 2018
Funder
EU, Horizon 2020, 675412Swedish Research Council, 621-2014-6200
Note

QC 20180515

Available from: 2018-04-10 Created: 2018-04-10 Last updated: 2018-05-28Bibliographically approved
Guo, W., Gustafsson, L., Jansson, R., Hedhammar, M. & van der Wijngaart, W. (2018). FORMATION OF A THIN-WALLED SPIDER SILK TUBE ON A MICROMACHINED SCAFFOLD. In: 2018 IEEE MICRO ELECTRO MECHANICAL SYSTEMS (MEMS): . Paper presented at 31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS), JAN 21-25, 2018, Belfast, NORTH IRELAND (pp. 83-85). IEEE
Open this publication in new window or tab >>FORMATION OF A THIN-WALLED SPIDER SILK TUBE ON A MICROMACHINED SCAFFOLD
Show others...
2018 (English)In: 2018 IEEE MICRO ELECTRO MECHANICAL SYSTEMS (MEMS), IEEE , 2018, p. 83-85Conference paper, Published paper (Refereed)
Abstract [en]

This paper reports on the first formation of a thin bio-functionalized spider silk tube, supported by an internal micromachined scaffold, in which both the inside and outside of the tube wall are freely accessible. The silk tube could potentially be used as an artificial blood vessel in an in vitro tissue scaffold, where endothelial cells and tissue cells can grow on both sides of the silk tube.

Place, publisher, year, edition, pages
IEEE, 2018
Series
Proceedings IEEE Micro Electro Mechanical Systems, ISSN 1084-6999
National Category
Other Medical Biotechnology
Identifiers
urn:nbn:se:kth:diva-231654 (URN)000434960900023 ()2-s2.0-85047021023 (Scopus ID)978-1-5386-4782-0 (ISBN)
Conference
31st IEEE International Conference on Micro Electro Mechanical Systems (MEMS), JAN 21-25, 2018, Belfast, NORTH IRELAND
Note

QC 20180905

Available from: 2018-09-05 Created: 2018-09-05 Last updated: 2018-09-05Bibliographically approved
Zhou, X., Haraldsson, K. T., Nania, S., Ribet, F., Palano, G., Heuchel, R., . . . van der Wijngaart, W. M. (2018). Human Cell Encapsulation in Gel Microbeads with Cosynthesized Concentric Nanoporous Solid Shells. Advanced Functional Materials, 28(21), Article ID 1707129.
Open this publication in new window or tab >>Human Cell Encapsulation in Gel Microbeads with Cosynthesized Concentric Nanoporous Solid Shells
Show others...
2018 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 28, no 21, article id 1707129Article in journal (Refereed) Published
Abstract [en]

Encapsulation of therapeutic cells in core-shell microparticles has great promise for the treatment of a range of health conditions. Unresolved challenges related to control of the particle morphology, mechanical stability, and immunogenicity hinder dissemination of this promising approach. Here, a novel polymer material for cell encapsulation and a combined novel, easy to control, synthesis method are introduced. Core-shell cell encapsulation is demonstrated with a concentric core-shell morphology formed during a single UV exposure, resulting in particles that consist of a synthetic hydrogel core of polyethylene glycol diacrylate and a solid, but porous, shell of off-stoichiometric thiol-ene. The encapsulated human cells in 100 mu m diameter particles have >90% viability. The average shell thickness is controlled between 7 and 13 mu m by varying the UV exposure, and the shell is measured to be permeable to low molecular weight species (<180 Da) but impermeable to higher molecular weight species (>480 Da). The unique material properties and the orthogonal control of the microparticle core size, shell thickness, shell permeability, and shell surface properties address the key unresolved challenges in the field, and are expected to enable faster translation of novel cell therapy concepts from research to clinical practice.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH, 2018
Keywords
cell encapsulation, cell therapy, droplet microfluidics, off-stoichiometry thiol-ene polymers, OSTE, PEGDA, poly(ethylene glycol) diacrylate
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:kth:diva-231217 (URN)10.1002/adfm.201707129 (DOI)000434030500006 ()2-s2.0-85045190003 (Scopus ID)
Note

QC 20180628

Available from: 2018-06-28 Created: 2018-06-28 Last updated: 2018-06-28Bibliographically approved
Vastesson, A., Guo, M., Haraldsson, T. & van der Wijngaart, W. (2018). Polymer Nanoliter Well Arrays for Liquid Storage and Rapid On-demand Electrochemical Release. Sensors and actuators. B, Chemical, 267, 111-118
Open this publication in new window or tab >>Polymer Nanoliter Well Arrays for Liquid Storage and Rapid On-demand Electrochemical Release
2018 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 267, p. 111-118Article in journal (Refereed) Published
Abstract [en]

Polymer microfluidic systems are of increasing importance in several applications in biomedicine and biosensing. The integrated encapsulation, storage, and controlled release of small amounts of liquid in such systems remains an unresolved technical challenge. Here, we report two methods for the room-temperature and adhesive-free sealing of 1–330 nanoliter volumes of liquid in off-stoichiometry thiol-ene polymer well arrays by spontaneous bonding to 200 nm thin gold films. Sealed well arrays were stored for more than one month in a liquid environment with <10% liquid loss, and for more than one week in air with minimal loss. We demonstrated that controlling the electrical potential and polarity over encapsulated wells allowed for selecting one of two well opening mechanisms: slow anodic electrochemical etching, or rapid electrolytic gas pressure-induced bursting of the gold film. The results may find potential applications in diagnostic testing, in vivo drug delivery, or in spatio-temporal release of chemical compounds in biological assays.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
nanoliter liquid encapsulation, nanoliter liquid storage, electrochemical liquid release, off-stoichiometry thiol-ene (OSTE) polymer, nanoliter well arrays
National Category
Polymer Technologies Medical Biotechnology Biomedical Laboratory Science/Technology Electrical Engineering, Electronic Engineering, Information Engineering
Research subject
Electrical Engineering
Identifiers
urn:nbn:se:kth:diva-215017 (URN)10.1016/j.snb.2018.04.013 (DOI)000432775600014 ()2-s2.0-85045401734 (Scopus ID)
Note

QC 20180515

Available from: 2017-09-29 Created: 2017-09-29 Last updated: 2018-09-18Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-8248-6670

Search in DiVA

Show all publications