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Batili, H., Hamawandi, B., Ergül, A. B., Szukiewicz, R., Kuchowicz, M. & Toprak, M. (2024). A comparative study on the surface chemistry and electronic transport properties of Bi2Te3 synthesized through hydrothermal and thermolysis routes. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 682, Article ID 132898.
Open this publication in new window or tab >>A comparative study on the surface chemistry and electronic transport properties of Bi2Te3 synthesized through hydrothermal and thermolysis routes
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2024 (English)In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, ISSN 0927-7757, E-ISSN 1873-4359, Vol. 682, article id 132898Article in journal (Refereed) Published
Abstract [en]

Bismuth telluride-Bi2Te3 is the most promising material for harvesting thermal energy near room temperature. There are numerous works on Bi2Te3 reporting significantly different transport properties, with no clear connection to the synthetic routes used and the resultant surface chemistry of the synthesized materials. It is of utmost importance to characterize the constituent particles’ surface and interfaces to get a better understanding of their influence on the transport properties, that will significantly improve the material design starting from the synthesis step. Electrophoretic deposition (EPD) is a promising technique, enabling the formation of thick films using colloidally stabilized suspensions of pre-made nanoparticles, which can enable the study of the effect of surface chemistry, in connection to the synthetic route, on the material's transport properties. In order to explore the differences in surface chemistry and the resultant transport properties in relation to the synthetic scheme used, here we report on Bi2Te3 synthesised through two wet-chemical routes in water (Hydro-) and oil (Thermo-) as the solvents. XRD analysis showed a high phase purity of the synthesized materials. SEM analysis revealed hexagonal platelet morphology of the synthesized materials, which were then used to fabricate EPD films. Characterization of the EPD films reveal significant differences between the Hydro- and Thermo-Bi2Te3 samples, leading to about 8 times better electrical conductivity values in the Thermo-Bi2Te3. XPS analysis revealed a higher metal oxides content in the Hydro-Bi2Te3 sample, contributing to the formation of a resistive layer, thus lowering the electrical conductivity. Arrhenius plots of electrical conductivity vs inverse temperature was used for the estimation of the activation energy for conduction, revealing a higher activation energy need for the Hydro-Bi2Te3 film, in agreement with the resistive barrier oxide content. Both the samples exhibited negative Seebeck coefficient (S) in the order of 160–170 mV/K. The small difference in S of Hydro- and Themo-Bi2Te3 films was explained by the effective medium theory, revealing that the magnitude of S is linearly correlated with the surface oxide content. Based on the findings, TE materials synthesized through thermolysis route is recommended for further studies using soft treatment/processing of pre-made TE materials. EPD platform presented here is shown to clearly expose the differences in the electronic transport in connection to nanoparticle surface chemistry, proving a promising methodology for the evaluation of morphology, size and surface chemistry dependence of electronic transport for a wide range of materials.

Place, publisher, year, edition, pages
Elsevier BV, 2024
Keywords
Bismuth telluride, Bi Te 2 3, Electrophoretic deposition, EPD, Hydrothermal, Nanoparticles, Power factor, Seebeck coefficient, Thermoelectric, Thermolysis
National Category
Materials Chemistry Physical Chemistry
Identifiers
urn:nbn:se:kth:diva-341599 (URN)10.1016/j.colsurfa.2023.132898 (DOI)001138909400001 ()2-s2.0-85179473751 (Scopus ID)
Note

QC 20231227

Available from: 2023-12-27 Created: 2023-12-27 Last updated: 2024-02-02Bibliographically approved
Abdollahi, F., Saghatchi, M., Paryab, A., Malek Khachatourian, A., Stephens, E. D., Toprak, M. & Badv, M. (2024). Angiogenesis in bone tissue engineering via ceramic scaffolds: A review of concepts and recent advancements. Biomaterials Advances, 159, Article ID 213828.
Open this publication in new window or tab >>Angiogenesis in bone tissue engineering via ceramic scaffolds: A review of concepts and recent advancements
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2024 (English)In: Biomaterials Advances, E-ISSN 2772-9508, Vol. 159, article id 213828Article, review/survey (Refereed) Published
Abstract [en]

Due to organ donor shortages, long transplant waitlists, and the complications/limitations associated with auto and allotransplantation, biomaterials and tissue-engineered models are gaining attention as feasible alternatives for replacing and reconstructing damaged organs and tissues. Among various tissue engineering applications, bone tissue engineering has become a promising strategy to replace or repair damaged bone. We aimed to provide an overview of bioactive ceramic scaffolds in bone tissue engineering, focusing on angiogenesis and the effect of different biofunctionalization strategies. Different routes to angiogenesis, including chemical induction through signaling molecules immobilized covalently or non-covalently, in situ secretion of angiogenic growth factors, and the degradation of inorganic scaffolds, are described. Physical induction mechanisms are also discussed, followed by a review of methods for fabricating bioactive ceramic scaffolds via microfabrication methods, such as photolithography and 3D printing. Finally, the strengths and weaknesses of the commonly used methodologies and future directions are discussed.

Place, publisher, year, edition, pages
Elsevier BV, 2024
Keywords
Angiogenesis, Bioceramic, Biofabrication, Biofunctionalization, Bone tissue engineering, Ceramic scaffolds
National Category
Biomaterials Science
Identifiers
urn:nbn:se:kth:diva-344548 (URN)10.1016/j.bioadv.2024.213828 (DOI)2-s2.0-85187225615 (Scopus ID)
Note

QC 20240321

Available from: 2024-03-20 Created: 2024-03-20 Last updated: 2024-03-21Bibliographically approved
Arsana, K. G. .., Saladino, G., Brodin, B., Toprak, M. & Hertz, H. (2024). Laboratory Liquid-Jet X-ray Microscopy and X-ray Fluorescence Imaging for Biomedical Applications. International Journal of Molecular Sciences, 25(2), Article ID 920.
Open this publication in new window or tab >>Laboratory Liquid-Jet X-ray Microscopy and X-ray Fluorescence Imaging for Biomedical Applications
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2024 (English)In: International Journal of Molecular Sciences, ISSN 1661-6596, E-ISSN 1422-0067, Vol. 25, no 2, article id 920Article in journal (Refereed) Published
Abstract [en]

Diffraction-limited resolution and low penetration depth are fundamental constraints in optical microscopy and in vivo imaging. Recently, liquid-jet X-ray technology has enabled the generation of X-rays with high-power intensities in laboratory settings. By allowing the observation of cellular processes in their natural state, liquid-jet soft X-ray microscopy (SXM) can provide morphological information on living cells without staining. Furthermore, X-ray fluorescence imaging (XFI) permits the tracking of contrast agents in vivo with high elemental specificity, going beyond attenuation contrast. In this study, we established a methodology to investigate nanoparticle (NP) interactions in vitro and in vivo, solely based on X-ray imaging. We employed soft (0.5 keV) and hard (24 keV) X-rays for cellular studies and preclinical evaluations, respectively. Our results demonstrated the possibility of localizing NPs in the intracellular environment via SXM and evaluating their biodistribution with in vivo multiplexed XFI. We envisage that laboratory liquid-jet X-ray technology will significantly contribute to advancing our understanding of biological systems in the field of nanomedical research.

Place, publisher, year, edition, pages
MDPI AG, 2024
Keywords
bioimaging, cell imaging, liquid-jet X-ray source, multiplexed imaging, nanomedicine, stain-free imaging, X-ray fluorescence imaging, X-ray microscopy
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:kth:diva-343205 (URN)10.3390/ijms25020920 (DOI)001151313100001 ()38255992 (PubMedID)2-s2.0-85183335794 (Scopus ID)
Note

QC 20240209

Available from: 2024-02-08 Created: 2024-02-08 Last updated: 2024-02-22Bibliographically approved
Batili, H., Hamawandi, B., Parsa, P., Ergül, A., Szukiewicz, R., Kuchowicz, M. & Toprak, M. (2023). Electrophoretic assembly and electronic transport properties of rapidly synthesized Sb2Te3 nanoparticles. Applied Surface Science, 637, Article ID 157930.
Open this publication in new window or tab >>Electrophoretic assembly and electronic transport properties of rapidly synthesized Sb2Te3 nanoparticles
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2023 (English)In: Applied Surface Science, ISSN 0169-4332, E-ISSN 1873-5584, Vol. 637, article id 157930Article in journal (Refereed) Published
Abstract [en]

With the recent advances in thermoelectric (TE) technology, there is an increasing demand to develop thick films that would enable large-scale TE devices. Assembly of TE-films from size and morphology-controlled nano particles has been a challenging issue that can be addressed by the use of electrophoretic deposition (EPD) technique. In this work, morphology-controlled Sb2Te3 nanoparticles were synthesized through microwave assisted thermolysis, which were subsequently used for EPD of TE films on specially developed glass substrates. The electronic transport properties were measured in the temp-range of 22-45 degrees C. The as-made EPD films showed a high initial resistance, ascribed to high porosity and the presence of surface oxide/passivating layers. The impact of two types of small organic molecules-as hexanedithiol and dodecanethiol, on the electronic transport was investigated, resulting in a significant improvement in the electrical conductivity of the films. The XPS analysis suggests that the thiols bind to the surface of nanoparticles through formation of sulfides. Seebeck coefficient in the range of + 160 to + 190 & mu;V/K was measured, revealing the p-type transport through the deposited films. Finally, a power factor of about 2.5 & mu;W/K2.m was estimated the first time for p-type EPD films, revealing the potential of the developed nanoparticles and substrate, the small molecule additives and the EPD process presented in this work.

Place, publisher, year, edition, pages
Elsevier BV, 2023
Keywords
Thermoelectric, Antimony telluride, Sb 2 Te 3, Electrophoretic deposition, EPD, Thermoelectric power factor, Seebeck coefficient, Colloidal synthesis and stabilization, Ligand exchange, Photolithography
National Category
Other Physics Topics
Identifiers
urn:nbn:se:kth:diva-334293 (URN)10.1016/j.apsusc.2023.157930 (DOI)001039594400001 ()2-s2.0-85164220691 (Scopus ID)
Note

QC 20231122

Available from: 2023-08-18 Created: 2023-08-18 Last updated: 2023-11-22Bibliographically approved
Azadpour, B., Aharipour, N., Paryab, A., Omid, H., Abdollahi, S., Madaah Hosseini, H., . . . Seifalian, A. M. (2023). Magnetically-assisted viral transduction (magnetofection) medical applications: An update. Biomaterials Advances, 154, Article ID 213657.
Open this publication in new window or tab >>Magnetically-assisted viral transduction (magnetofection) medical applications: An update
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2023 (English)In: Biomaterials Advances, E-ISSN 2772-9508, Vol. 154, article id 213657Article, review/survey (Refereed) Published
Abstract [en]

Gene therapy involves replacing a faulty gene or adding a new gene inside the body's cells to cure disease or improve the body's ability to fight disease. Its popularity is evident from emerging concepts such as CRISPR-based genome editing and epigenetic studies and has been moved to a clinical setting. The strategy for therapeutic gene design includes; suppressing the expression of pathogenic genes, enhancing necessary protein production, and stimulating the immune system, which can be incorporated into both viral and non-viral gene vectors. Although non-viral gene delivery provides a safer platform, it suffers from an inefficient rate of gene transfection, which means a few genes could be successfully transfected and expressed within the cells. Incorporating nucleic acids into the viruses and using these viral vectors to infect cells increases gene transfection efficiency. Consequently, more cells will respond, more genes will be expressed, and sustained and successful gene therapy can be achieved. Combining nanoparticles (NPs) and nucleic acids protects genetic materials from enzymatic degradation. Furthermore, the vectors can be transferred faster, facilitating cell attachment and cellular uptake. Magnetically assisted viral transduction (magnetofection) enhances gene therapy efficiency by mixing magnetic nanoparticles (MNPs) with gene vectors and exerting a magnetic field to guide a significant number of vectors directly onto the cells. This research critically reviews the MNPs and the physiochemical properties needed to assemble an appropriate magnetic viral vector, discussing cellular hurdles and attitudes toward overcoming these barriers to reach clinical gene therapy perspectives. We focus on the studies conducted on the various applications of magnetic viral vectors in cancer therapies, regenerative medicine, tissue engineering, cell sorting, and virus isolation.

Place, publisher, year, edition, pages
Elsevier BV, 2023
Keywords
Cancer gene therapy, Magnetic nanoparticles, Magnetically-assisted viral gene delivery, Magnetofection, Transfection
National Category
Microbiology in the medical area
Identifiers
urn:nbn:se:kth:diva-339001 (URN)10.1016/j.bioadv.2023.213657 (DOI)2-s2.0-85173879787 (Scopus ID)
Note

QC 20231101

Available from: 2023-11-01 Created: 2023-11-01 Last updated: 2023-11-01Bibliographically approved
Saladino, G., Kakadiya, R., Ansari, S. R., Teleki, A. & Toprak, M. (2023). Magnetoresponsive fluorescent core–shell nanoclusters for biomedical applications. Nanoscale Advances, 5(5), 1323-1330
Open this publication in new window or tab >>Magnetoresponsive fluorescent core–shell nanoclusters for biomedical applications
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2023 (English)In: Nanoscale Advances, E-ISSN 2516-0230, Vol. 5, no 5, p. 1323-1330Article in journal (Refereed) Published
Abstract [en]

Nowadays, superparamagnetic iron oxide nanoparticles (SPIONs) have a dominant role in many subfields of biomedicine. Owing to their peculiar properties, they can be employed for magnetic separation, drug delivery, diagnostics, and hyperthermia treatments. However, these magnetic nanoparticles (NPs) suffer from low unit magnetization due to size constraints (up to 20-30 nm) to exhibit superparamagnetic character. In this work, we have designed and synthesized superparamagnetic nanoclusters (SP-NCs) with diameters of up to 400 nm with high unit magnetization for enhanced loading capacity. These were synthesized with conventional or microwave-assisted solvothermal methods, in the presence of either of the two biomolecules (citrate or l-lysine) as the capping agent. Primary particle size, SP-NC size, surface chemistry, and the resultant magnetic properties were observed to be significantly influenced by the choice of synthesis route and capping agent. Selected SP-NCs were then coated with a fluorophore-doped silica shell to provide fluorescence properties, in the near-infrared spectrum region, while silica provided high chemical and colloidal stability. Heating efficiency studies were performed under alternating magnetic field on the synthesized SP-NCs, highlighting their potential in hyperthermia treatment. We envision that their enhanced magnetically-active content, fluorescence, magnetic property, and heating efficiency will pave the way to more effective uses in biomedical applications.

Place, publisher, year, edition, pages
Royal Society of Chemistry (RSC), 2023
National Category
Nano Technology
Identifiers
urn:nbn:se:kth:diva-338019 (URN)10.1039/d2na00887d (DOI)000928612000001 ()36866251 (PubMedID)2-s2.0-85148631781 (Scopus ID)
Funder
Knut and Alice Wallenberg Foundation, 2016.0057EU, Horizon 2020, 101002582Science for Life Laboratory, SciLifeLab
Note

QC 20231016

Available from: 2023-10-12 Created: 2023-10-12 Last updated: 2024-02-22Bibliographically approved
Vogt, C., Saladino, G., Shaker, K., Arsenian-Henriksson, M., Hertz, H., Toprak, M. & Brodin, B. (2023). Organ uptake, toxicity and skin clearance of ruthenium contrast agents monitored in vivo by x-ray fluorescence. Nanomedicine, 18(18), 1161-1173
Open this publication in new window or tab >>Organ uptake, toxicity and skin clearance of ruthenium contrast agents monitored in vivo by x-ray fluorescence
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2023 (English)In: Nanomedicine, ISSN 1743-5889, E-ISSN 1748-6963, Vol. 18, no 18, p. 1161-1173Article in journal (Refereed) Published
Abstract [en]

Aims: To investigate the distribution and toxicity of ruthenium nanoparticles (Ru NPs) injected intravenously in mice.

Methods: We synthesized Ru NPs, followed their biodistribution by x-ray fluorescence (XRF) imaging and evaluated organ toxicity by histopathology and gene expression.

Results: Ru NPs accumulated, mainly in liver and spleen, where they were phagocyted by tissue macrophages, giving a transient inflammation and oxidative stress response that declined after 2 weeks. Ru NPs gradually accumulated in the skin, which was confirmed by microscopic examination of skin biopsies.

Conclusion: Ru NP toxicity in recipient organs is transient. Particles are at least partially excreted by the skin, supporting a role for the skin as a nanoparticle clearing organ.

Place, publisher, year, edition, pages
Future Medicine Ltd, 2023
Keywords
contrast agents, imaging nanoparticles, in vivo imaging, medical imaging, metal nanoparticles, nanoparticle clearance, nanotoxicity, x-ray fluorescence
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:kth:diva-338020 (URN)10.2217/nnm-2023-0061 (DOI)001061631900001 ()37665018 (PubMedID)2-s2.0-85172828110 (Scopus ID)
Funder
Knut and Alice Wallenberg Foundation, KAW 2016.0057
Note

QC 20231013

Available from: 2023-10-12 Created: 2023-10-12 Last updated: 2024-02-22Bibliographically approved
Kilic, N. I., Saladino, G. M., Johansson, S., Shen, R., McDorman, C., Toprak, M. & Johansson, S. (2023). Two-Photon Polymerization Printing with High Metal Nanoparticle Loading. ACS Applied Materials and Interfaces, 15(42), 49794-49804
Open this publication in new window or tab >>Two-Photon Polymerization Printing with High Metal Nanoparticle Loading
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2023 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 15, no 42, p. 49794-49804Article in journal (Refereed) Published
Abstract [en]

Two-photon polymerization (2PP) is an efficient technique to achieve high-resolution, three-dimensional (3D)-printed complex structures. However, it is restricted to photocurable monomer combinations, thus presenting constraints when aiming at attaining functionally active resist formulations and structures. In this context, metal nanoparticle (NP) integration as an additive can enable functionality and pave the way to more dedicated applications. Challenges lay on the maximum NP concentrations that can be incorporated into photocurable resist formulations due to the laser-triggered interactions, which primarily originate from laser scattering and absorption, as well as the limited dispersibility threshold. In this study, we propose an approach to address these two constraints by integrating metallic Rh NPs formed ex situ, purposely designed for this scope. The absence of surface plasmon resonance (SPR) within the visible and near-infrared spectra, coupled with the limited absorption value measured at the laser operating wavelength (780 nm), significantly limits the laser-induced interactions. Moreover, the dispersibility threshold is increased by engineering the NP surface to be compatible with the photocurable resin, permitting us to achieve concentrations of up to 2 wt %, which, to our knowledge, is significantly higher than the previously reported limit (or threshold) for embedded metal NPs. Another distinctive advantage of employing Rh NPs is their role as promising contrast agents for X-ray fluorescence (XRF) bioimaging. We demonstrated the presence of Rh NPs within the whole 2PP-printed structure and emphasized the potential use of NP-loaded 3D-printed nanostructures for medical devices.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2023
Keywords
additive manufacturing, metal nanoparticles, nanoparticle surface engineering, two-photon polymerization, X-ray fluorescence
National Category
Manufacturing, Surface and Joining Technology
Identifiers
urn:nbn:se:kth:diva-339514 (URN)10.1021/acsami.3c10581 (DOI)001082684900001 ()37816209 (PubMedID)2-s2.0-85175269890 (Scopus ID)
Note

QC 20231114

Available from: 2023-11-14 Created: 2023-11-14 Last updated: 2024-02-22Bibliographically approved
Costa, A. L., Blosi, M., Brigliadori, A., Zanoni, I., Ortelli, S., Simeone, F. C., . . . Gardini, D. (2022). Eco design for Ag-based solutions against SARS-CoV-2 and E. coli. Environmental Science: Nano, 9(11), 4295-4304
Open this publication in new window or tab >>Eco design for Ag-based solutions against SARS-CoV-2 and E. coli
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2022 (English)In: Environmental Science: Nano, ISSN 2051-8153, Vol. 9, no 11, p. 4295-4304Article in journal (Refereed) Published
Abstract [en]

For the first time, we exploited the antiviral and antibacterial properties of Ag NPs stabilised by quaternized hydroxyethyl cellulose (Ag-HEC) against SARS-CoV-2 and Escherichia coli through an eco-friendly process at room temperature in three different environments: 1) water, where Ag was dispersed as a nanosol, 2) textiles, where Ag was applied as a coating, and 3) hydrogel where Ag is embedded. The antiviral performance of Ag-HEC nanosols was quantified through the selectivity index (SI), defined as the ratio between 50% cytotoxic and inhibitory concentration, in order to evaluate the ability to be active in a concentration range below the cytotoxicity value. The collected results pointed out an actual enhanced risk/benefit profile of Ag-HEC NPs with respect to chloroquine, with an SI of 22.2 and 8.4, respectively. Antibacterial and antiviral activities of Ag-HEC NPs immobilized on textiles or mucosa-like hydrogels were also assessed and their efficacy in potential application as protective clothing or nasal molecular masks was verified. This work demonstrated that a modern, safe and sustainable design allows traditional colloidal silver-based technologies to be efficiently exploited for a broad spectrum of antimicrobial solutions against bacterial and viral infections.

Place, publisher, year, edition, pages
Royal Society of Chemistry (RSC), 2022
Keywords
Coronavirus, Escherichia coli, Hydrogels, Protective clothing, Sols, Sustainable development, Antibacterial properties, Antiviral properties, Antivirals, Cytotoxic, E. coli, Eco-friendly process, Inhibitory concentration, Nanosols, Performance, Selectivity index, Textiles, cellulose, coliform bacterium, design, nanoparticle, severe acute respiratory syndrome, silver, Concentration, Processes, Solutions
National Category
Nano Technology Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:kth:diva-328945 (URN)10.1039/d2en00178k (DOI)000868802900001 ()2-s2.0-85141418865 (Scopus ID)
Note

QC 20230614

Available from: 2023-06-14 Created: 2023-06-14 Last updated: 2023-06-14Bibliographically approved
Saladino, G. M., Kilic, N. I., Shaker, K., Li, Y., Hamawandi, B., Vogt, C., . . . Toprak, M. (2022). Functional Coatings for X-ray Fluorescent Nanoparticles. In: Proceedings of the 6th International Conference on Theoretical and Applied Nanoscience and Nanotechnology, TANN 2022: . Paper presented at Proceedings of the 6th International Conference on Theoretical and Applied Nanoscience and Nanotechnology, TANN 2022, Niagara Falls, Canada, Jun 2 2022 - Jun 4 2022. Avestia Publishing
Open this publication in new window or tab >>Functional Coatings for X-ray Fluorescent Nanoparticles
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2022 (English)In: Proceedings of the 6th International Conference on Theoretical and Applied Nanoscience and Nanotechnology, TANN 2022, Avestia Publishing , 2022Conference paper, Published paper (Refereed)
Abstract [en]

In recent years, the design and synthesis of bio-compatible coatings leading to hybrid nanoparticles (NPs) as the contrast agents have gained substantial relevance. Furthermore, the addition of several functionalities for bio-imaging applications represents a key step for non-invasive bio-diagnostics. In this context, we design and utilize hybrid nanostructures for X-ray fluorescence computed tomography (XFCT). The combination of a ceramic or metallic core–based on MoO2, Rh or Ru–with a protective shell allows the generation of bio-compatible nanohybrids for dual mode bio-imaging, where the core NPs constitute the X-ray fluorescence (XRF) contrast agents [1]–[3]. Core NPs are synthesized via polyol, hydrothermal or microwave-assisted hydrothermal methods, yielding uniform shape and high dispersibility in aqueous media. Different approaches have been pursued for the fabrication of a bio-compatible shell coating. A modified sol-gel based silica coating process, doped with a commercial fluorophore (Cy5.5), was developed and shown to be applicable to both ceramic and metallic NPs [4], forming core-shell NPs with both optical and X-ray fluorescence properties. Alternatively, carbon quantum dots (CQDs) were synthesized via citrate pyrolysis using microwave-assisted hydrothermal method, exhibiting uniform size distribution (1.6±0.4 nm) and excitation-independent emission (440 nm). Conjugation of these CQDs, via cross-linking, with Rh NPs led to excitation-independent hybrid NPs, with a red-shifted emission wavelength (520 nm), attributed to the reduction of pyrrolic nitrogen on CQDs [5]. These hybrid NPs exhibit improved in vitro biocompatibility in comparison with bare XRF contrast agents. Furthermore, the optical fluorescence–provided by Cy5.5 or CQDs–allows the localization of the NPs in the intracellular environment while the XRF signal from the core NPs is utilized for XFCT, in small animals, leading to both a microscopic and macroscopic bio-imaging contrast agent.

Place, publisher, year, edition, pages
Avestia Publishing, 2022
National Category
Materials Chemistry
Identifiers
urn:nbn:se:kth:diva-338379 (URN)10.11159/tann22.129 (DOI)2-s2.0-85173044731 (Scopus ID)
Conference
Proceedings of the 6th International Conference on Theoretical and Applied Nanoscience and Nanotechnology, TANN 2022, Niagara Falls, Canada, Jun 2 2022 - Jun 4 2022
Note

Part of proceedings ISBN 9781990800030

QC 20231023

Available from: 2023-10-23 Created: 2023-10-23 Last updated: 2023-10-23Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-5678-5298

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