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Publications (10 of 157) Show all publications
Sippl, N., Grosso, G., Ferrannini, G., de Faire, U., Lindahl, B., Näsman, P., . . . Amara, K. (2019). Domain specific anti-beta 2GPI antibodies in patients with First Myocardial Infarction. Lupus, 28, 39-40
Open this publication in new window or tab >>Domain specific anti-beta 2GPI antibodies in patients with First Myocardial Infarction
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2019 (English)In: Lupus, ISSN 0961-2033, E-ISSN 1477-0962, Vol. 28, p. 39-40Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD, 2019
National Category
Rheumatology and Autoimmunity
Identifiers
urn:nbn:se:kth:diva-261330 (URN)10.1177/0961203319872604 (DOI)000486295800083 ()
Note

QC 20191007

Available from: 2019-10-07 Created: 2019-10-07 Last updated: 2019-10-07Bibliographically approved
Ferrannini, G., Svenungsson, E., Kjellstrom, B., Elvin, K., Grosso, G., Näsman, P., . . . Norhammar, A. (2019). Dysglycaemic patients with antiphospholipid antibodies IgG: a neglected group at high cardiovascular risk?. Lupus, 28, 42-42
Open this publication in new window or tab >>Dysglycaemic patients with antiphospholipid antibodies IgG: a neglected group at high cardiovascular risk?
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2019 (English)In: Lupus, ISSN 0961-2033, E-ISSN 1477-0962, Vol. 28, p. 42-42Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD, 2019
National Category
Rheumatology and Autoimmunity
Identifiers
urn:nbn:se:kth:diva-261329 (URN)10.1177/0961203319872604 (DOI)000486295800088 ()
Note

QC 20191007

Available from: 2019-10-07 Created: 2019-10-07 Last updated: 2019-10-07Bibliographically approved
Ceccato, V., Näsman, P., Catherine, S. & Langefors, L. (2019). Trygghet i kollektivtrafiken i Stockholm i ett internationellt perspektiv: En handlingsplan mot sexuella trakasserier och brott i transitmiljöer. Stockholm: Kungliga tekniska högskolan
Open this publication in new window or tab >>Trygghet i kollektivtrafiken i Stockholm i ett internationellt perspektiv: En handlingsplan mot sexuella trakasserier och brott i transitmiljöer
2019 (Swedish)Report (Other academic)
Abstract [en]

Safety and security are human rights - to feel free from risk and fear of danger is crucial for all people and a prerequisite for modern society. Safety promotes and encourages mobility, which is basic for an individual’s quality of life. This report presents Stockholm students' responses to a survey of experiences and perceptions of sexual harassment and sexual transit crimes in public transport conducted in May-June 2018 as part of an international study. The study contained 1,122 young people surveyed at the Royal Institute of Technology (KTH) in Stockholm and 309 students from Södertörn University in Huddinge. We investigated the victimization of sexual harassment and sexual crimes in transit environments, feelings of perceived security or lack thereof, and necessary improvements to make travel safer.

Abstract [sv]

Säkerhet och trygghet är mänskliga rättigheter –att känna sig fri från risk och rädsla för fara är avgörande för alla människoroch en förutsättning för det moderna samhället. Säkerhet garanterar, i enhållbar stad, varje person en plats att leva fri från fara och fri från rädsla.Säkerhet främjar och uppmuntrar också rörlighet, som är grundläggande förindividens livskvalitet. Men för kvinnor (och särskilt unga kvinnor) är dettainte en självklarhet. Denna rapport presenterar Stockholmsstudenters svar på en undersökning om erfarenheter och uppfattningar om sexuella trakasserier och brott i kollektivtrafik som genomfördes i maj-juni 2018 som en del av en internationell studie. De 1,122 ungdomar som tillfrågades studerar på KTH Kungliga tekniska högskolan i Stockholm och 309 studenter från Södertörns högskola in Huddinge. Vi undersökte viktimiseringen av sexuella trakasserier och sexuella brott i transitmiljöer, känslor av upplevd trygghet eller bristen på dessa samt nödvändiga förbättringar som kan göra resorna tryggare.

Place, publisher, year, edition, pages
Stockholm: Kungliga tekniska högskolan, 2019. p. 50
Series
TRITA-ABE-RPT ; 1923
National Category
Other Social Sciences
Research subject
Planning and Decision Analysis, Urban and Regional Studies
Identifiers
urn:nbn:se:kth:diva-261407 (URN)10.13140/RG.2.2.10675.58400 (DOI)978-91-7873-329-3 (ISBN)
Note

QC 20191007

Available from: 2019-10-07 Created: 2019-10-07 Last updated: 2019-10-07Bibliographically approved
Norhammar, A., Kjellström, B., Habib, N., Gustafsson, A., Klinge, B., Nygren, Å., . . . Rydén, L. (2019). Undetected Dysglycemia Is an Important Risk Factor for Two Common Diseases, Myocardial Infarction and Periodontitis: A Report From the PAROKRANK Study. Diabetes Care, 42(8), 1504-1511
Open this publication in new window or tab >>Undetected Dysglycemia Is an Important Risk Factor for Two Common Diseases, Myocardial Infarction and Periodontitis: A Report From the PAROKRANK Study
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2019 (English)In: Diabetes Care, ISSN 0149-5992, E-ISSN 1935-5548, Vol. 42, no 8, p. 1504-1511Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Information on the relationship among dysglycemia (prediabetes or diabetes), myocardial infarction (MI), and periodontitis (PD) is limited. This study tests the hypothesis that undetected dysglycemia is associated with both conditions. RESEARCH DESIGN AND METHODS: The PAROKRANK (Periodontitis and Its Relation to Coronary Artery Disease) study included 805 patients with a first MI and 805 matched control subjects. All participants without diabetes (91%) were examined with an oral glucose tolerance test. Abnormal glucose tolerance (AGT) (impaired glucose tolerance or diabetes) was categorized according to the World Health Organization. Periodontal status was categorized from dental X-rays as healthy (≥80% remaining alveolar bone height), moderate (79-66%), or severe (<66%) PD. Odds ratios (ORs) and 95% CIs were calculated by logistic regression and were adjusted for age, sex, smoking, education, marital status, and explored associated risks of dysglycemia to PD and MI, respectively. RESULTS: AGT was more common in patients than in control subjects (32% vs. 19%; P < 0.001) and was associated with MI (OR 2.03; 95% CI 1.58-2.60). Undetected diabetes was associated with severe PD (2.50; 1.36-4.63) and more strongly in patients (2.35; 1.15-4.80) than in control subjects (1.80; 0.48-6.78), but not when categorized as AGT (total cohort: 1.07; 0.67-1.72). Severe PD was most frequent in subjects with undetected diabetes, and reversely undetected diabetes was most frequent in patients with severe PD. CONCLUSIONS: In this large case-control study previously undetected dysglycemia was independently associated to both MI and severe PD. In principal, it doubled the risk of a first MI and of severe PD. This supports the hypothesis that dysglycemia drives two common diseases, MI and PD.

Place, publisher, year, edition, pages
NLM (Medline), 2019
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:kth:diva-255735 (URN)10.2337/dc19-0018 (DOI)000476786200024 ()31182493 (PubMedID)2-s2.0-85070184039 (Scopus ID)
Note

QC 20190813

Available from: 2019-08-13 Created: 2019-08-13 Last updated: 2019-08-13Bibliographically approved
Oakes, B. D., Mattsson, L.-G., Näsman, P. & Glazunov, A. A. (2018). A Systems-Based Risk Assessment Framework for Intentional Electromagnetic Interference (IEMI) on Critical Infrastructures. Risk Analysis, 38(6), 1279-1305
Open this publication in new window or tab >>A Systems-Based Risk Assessment Framework for Intentional Electromagnetic Interference (IEMI) on Critical Infrastructures
2018 (English)In: Risk Analysis, ISSN 0272-4332, E-ISSN 1539-6924, Vol. 38, no 6, p. 1279-1305Article in journal (Refereed) Published
Abstract [en]

Modern infrastructures are becoming increasingly dependent on electronic systems, leaving them more vulnerable to electrical surges or electromagnetic interference. Electromagnetic disturbances appear in nature, e.g., lightning and solar wind; however, they may also be generated by man-made technology to maliciously damage or disturb electronic equipment. This article presents a systematic risk assessment framework for identifying possible, consequential, and plausible intentional electromagnetic interference (IEMI) attacks on an arbitrary distribution network infrastructure. In the absence of available data on IEMI occurrences, we find that a systems-based risk assessment is more useful than a probabilistic approach. We therefore modify the often applied definition of risk, i.e., a set of triplets containing scenario, probability, and consequence, to a set of quadruplets: scenario, resource requirements, plausibility, and consequence. Probability is replaced by resource requirements and plausibility, where the former is the minimum amount and type of equipment necessary to successfully carry out an attack scenario and the latter is a subjective assessment of the extent of the existence of attackers who possess the motivation, knowledge, and resources necessary to carry out the scenario. We apply the concept of intrusion areas and classify electromagnetic source technology according to key attributes. Worst-case scenarios are identified for different quantities of attacker resources. The most plausible and consequential of these are deemed the most important scenarios and should provide useful decision support in a countermeasures effort. Finally, an example of the proposed risk assessment framework, based on notional data, is provided on a hypothetical water distribution network.

Place, publisher, year, edition, pages
WILEY, 2018
Keywords
Critical infrastructures, intentional electromagnetic interference (IEMI), operational models, risk analysis, water distribution network
National Category
Transport Systems and Logistics
Identifiers
urn:nbn:se:kth:diva-231194 (URN)10.1111/risa.12945 (DOI)000434645900013 ()29314162 (PubMedID)2-s2.0-85040365367 (Scopus ID)
Funder
Swedish Civil Contingencies AgencyThe Swedish Post and Telecom Authority (PTS)
Note

QC 20180720

Available from: 2018-07-20 Created: 2018-07-20 Last updated: 2019-08-20Bibliographically approved
Eriksson, B., Wandell, P., Dahlstrom, U., Näsman, P., Lund, L. H. & Edner, M. (2018). Comorbidities, risk factors and outcomes in patients with heart failure and an ejection fraction of more than or equal to 40% in primary care- and hospital care-based outpatient clinics. Scandinavian Journal of Primary Health Care, 36(2), 207-215
Open this publication in new window or tab >>Comorbidities, risk factors and outcomes in patients with heart failure and an ejection fraction of more than or equal to 40% in primary care- and hospital care-based outpatient clinics
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2018 (English)In: Scandinavian Journal of Primary Health Care, ISSN 0281-3432, E-ISSN 1502-7724, Vol. 36, no 2, p. 207-215Article in journal (Refereed) Published
Abstract [en]

Objective: The aim of this study is to describe patients with heart failure and an ejection fraction (EF) of more than or equal to 40%, managed in both Primary- and Hospital based outpatient clinks separately with their prognosis, comorbidities and risk factors. Further to compare the heart failure medication in the two groups. Design: We used the prospective Swedish Heart Failure Registry to include 9654 out-patients who had HF and EF >= 40%, 1802 patients were registered in primary care and 7852 in hospital care. Descriptive statistical tests were used to analyze base line characteristics in the two groups and multivariate logistic regression analysis to assess mortality rate in the groups separately. Setting: The prospective Swedish Heart Failure Registry. Setting: The prospective Swedish Heart Failure Registry. Subjects: Patients with heart failure and an ejection fraction (EF) of more than or equal to 40%. Main outcome measures: Comorbidities, risk factors and mortality. Results: Mean-age was 77.5 (primary care) and 70.3 years (hospital care) p < 0.0001, 46.7 vs. 36.3% women respectively (p < 0.0001) and EF >= 50% 26.1 vs. 13.4% (p < 0.0001). Co-morbidities were common in both groups (97.2% vs. 92.3%), the primary care group having more atrial fibrillation, hypertension, ischemic heart disease and COPD. According to the multivariate logistic regression analysis smoking, COPD and diabetes were the most important independent risk factors in the primary care group and valvular disease in the hospital care group. All-cause mortality during mean follow-up of almost 4 years was 315% in primary care and 27.8% in hospital care. One year-mortality rates were 7.8%, and 7.0% respectively. Conclusion: Any co-morbidity was noted in 97% of the HF-patients with an EF of more than or equal to 40% managed at primary care based out-patient clinics and these patients had partly other independent risk factors than those patients managed in hospital care based outpatients clinics. Our results indicate that more attention should be payed to manage COPD in the primary care group.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD, 2018
Keywords
Heart failure, preserved ejection fraction, primary care, risk factors, outcome
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:kth:diva-228293 (URN)10.1080/02813432.2018.1459654 (DOI)000431601000013 ()29633886 (PubMedID)2-s2.0-85045147465 (Scopus ID)
Note

QC 20180521

Available from: 2018-05-21 Created: 2018-05-21 Last updated: 2018-05-21Bibliographically approved
Wang, A., Arver, S., Flanagan, J., Gyberg, V., Näsman, P., Ritsinger, V. & Mellbin, L. G. (2018). Dynamics of testosterone levels in patients with newly detected glucose abnormalities and acute myocardial infarction. Diabetes & Vascular Disease Research, 15(6), 511-518
Open this publication in new window or tab >>Dynamics of testosterone levels in patients with newly detected glucose abnormalities and acute myocardial infarction
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2018 (English)In: Diabetes & Vascular Disease Research, ISSN 1479-1641, E-ISSN 1752-8984, Vol. 15, no 6, p. 511-518Article in journal (Refereed) Published
Abstract [en]

Objective: Low testosterone has been associated with increased cardiovascular risk and glucose abnormalities. This study explored the prevalence of low testosterone, dynamics over time and prognostic implications in acute myocardial infarction patients with or without glucose abnormalities. Methods: Male acute myocardial infarction patients (n = 123) and healthy controls (n = 124) were categorised as having normal or abnormal glucose tolerance (impaired glucose tolerance or diabetes) by oral glucose tolerance testing. Testosterone was measured at hospital admission, discharge, 3 and 12 months thereafter in patients. Patients and controls were followed for 11 years for major cardiovascular events (cardiovascular death/acute myocardial infarction/stroke/severe heart failure). Results: At hospital admission, more patients had low testosterone (<= 300 ng/dl) and lower median levels than controls (64 vs 28%; p < 0.001 and 243 vs 380 ng/dl; p < 0.01). At the subsequent time points, testosterone had increased to 311, 345 and 357 ng/dl. Patients with abnormal glucose tolerance had the highest prevalence (75%) of low levels. In adjusted Cox regression models, neither total nor free testosterone predicted major cardiovascular events. Conclusion: Low testosterone levels were common in male acute myocardial infarction patients in the acute phase, especially in the presence of abnormal glucose tolerance, but increased over time indicating that testosterone measured in close proximity to acute myocardial infarction should be interpreted with caution.

Place, publisher, year, edition, pages
Sage Publications, 2018
Keywords
Testosterone, diabetes mellitus type 2, glucose intolerance, prediabetic state, myocardial infarction, prognosis
National Category
Health Sciences
Identifiers
urn:nbn:se:kth:diva-239792 (URN)10.1177/1479164118802543 (DOI)000450313700005 ()30280926 (PubMedID)2-s2.0-85056343096 (Scopus ID)
Note

QC 20190108

Available from: 2019-01-08 Created: 2019-01-08 Last updated: 2019-01-17Bibliographically approved
Lundstrom, E., Isaksson, E., Wester, P., Laska, A.-C. & Näsman, P. (2018). Enhancing Recruitment Using Teleconference and Commitment Contract (ERUTECC): study protocol for a randomised, stepped-wedge cluster trial within the EFFECTS trial. Trials, 19, Article ID 14.
Open this publication in new window or tab >>Enhancing Recruitment Using Teleconference and Commitment Contract (ERUTECC): study protocol for a randomised, stepped-wedge cluster trial within the EFFECTS trial
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2018 (English)In: Trials, ISSN 1745-6215, E-ISSN 1745-6215, Vol. 19, article id 14Article in journal (Refereed) Published
Abstract [en]

Background: Many randomised controlled trials (RCTs) fail to meet their recruitment goals in time. Trialists are advised to include study recruitment strategies within their trials. EFFECTS is a Swedish, academic-led RCT of fluoxetine for stroke recovery. The trial's primary objective is to investigate whether 20 mg fluoxetine daily compared with placebo for 6 months after an acute stroke improves the patient's functional outcome. The first patient was included on 20 October 2014 and, as of 31 August 2017, EFFECTS has included 810 of planned 1500 individuals. EFFECTS currently has 32 active centres. The primary objective of the ERUTECC (Enhancing Recruitment Using Teleconference and Commitment Contract) study is to investigate whether a structured teleconference re-visit with the study personnel at the centres, accompanied by a commitment contract, can enhance recruitment by 20% at 60 days post intervention, compared with 60 days pre-intervention, in an ongoing RCT. Methods: ERUTECC is a randomised, stepped-wedge cluster trial embedded in EFFECTS. The plan is to start ERUTECC with a running-in period of September 2017. The first intervention is due in October 2017, and the study will continue for 12 months. We are planning to intervene at all active centres in EFFECTS, except the five top recruiting centres (n=27). The rationale for not intervening at the top recruiting centres is that we believe they have reached their full potential and the intervention would be too weak for them. The hypothesis of this study is that a structured teleconference re-visit with the study personnel at the centres, accompanied by a commitment contract, can enhance recruitment by 20% 60 days post intervention, compared to 60 days pre-intervention, in an ongoing RCT. Discussion: EFFECTS is a large, pragmatic RCT of stroke in Sweden. Results from the embedded ERUTECC study could probably be generalised to high-income Western countries, and is relevant to trial management and could improve trial management in the future. It might also be useful in clinical settings outside the field of stroke.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD, 2018
Keywords
Stroke, Randomised controlled trial, RCT, Recruitment, Randomised stepped-wedge cluster trial
National Category
Clinical Medicine
Identifiers
urn:nbn:se:kth:diva-221943 (URN)10.1186/s13063-017-2367-8 (DOI)000419608100004 ()29310679 (PubMedID)2-s2.0-85040447644 (Scopus ID)
Note

QC 20180130

Available from: 2018-01-30 Created: 2018-01-30 Last updated: 2018-01-30Bibliographically approved
Grosso, G., Sippl, N., Kjellstrom, B., Amara, K., de Faire, U., Elvin, K., . . . Svenungsson, E. (2018). IgG Antiphospholipid Antibodies, -a Common but Neglected Finding in Patients with Myocardial Infarction. Arthritis & Rheumatology, 70
Open this publication in new window or tab >>IgG Antiphospholipid Antibodies, -a Common but Neglected Finding in Patients with Myocardial Infarction
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2018 (English)In: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
WILEY, 2018
National Category
Clinical Medicine
Identifiers
urn:nbn:se:kth:diva-238544 (URN)000447268901388 ()
Note

QC 20181105

Available from: 2018-11-05 Created: 2018-11-05 Last updated: 2018-11-05Bibliographically approved
Rudberg, A.-S., Berge, E., Gustavsson, A., Näsman, P. & Lundström, E. (2018). Long-term health-related quality of life, survival and costs by different levels of functional outcome six months after stroke. European Stroke Journal, 3(2), 157-164
Open this publication in new window or tab >>Long-term health-related quality of life, survival and costs by different levels of functional outcome six months after stroke
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2018 (English)In: European Stroke Journal, ISSN 2396-9873, E-ISSN 2396-9881, Vol. 3, no 2, p. 157-164Article in journal (Refereed) Published
Abstract [en]

Introduction: Information about the impact of functional outcome after stroke is currently missing on health-related quality of life, survival and costs. This information would be valuable for health economic evaluations and for allocation of resources in stroke health care. Patients and methods: Data on 297 Swedish patients included in the Third International Stroke Trial were analysed including functional outcome at six months (measured by Oxford Handicap Scale), health-related quality of life up to 18 months (EQ-5D-3L) and survival up to 36 months. We used record linkage to collect data on costs up to 36 months, using national patient registers. Results: Patients with a better functional outcome level at six months had a significantly better health-related quality of life at 18 months (p<0.05), better long-term survival (p<0.05) and lower costs (p<0.001), for all time points up to 36 months. The difference in costs was mainly due to differences in days spent in hospital (p<0.005). Discussion: This study showed an association between functional outcome at six months and health-related quality of life up to 18 months, and costs up to 36 months. Conclusion: Functional outcome six months after stroke is an important determinant of health-related quality of life, survival and costs over 36 months. Effective interventions aimed at reducing short-term disability levels are therefore also expected to reduce the overall burden of stroke.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD, 2018
Keywords
Stroke, quality adjusted life year, health economy, EQ-5D, functional level, survival
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:kth:diva-228418 (URN)10.1177/2396987317753444 (DOI)000432064200008 ()2-s2.0-85060508959 (Scopus ID)
Note

QC 20180528

Available from: 2018-05-28 Created: 2018-05-28 Last updated: 2019-08-20Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-7606-8771

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