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Näsman, Per, DocentORCID iD iconorcid.org/0000-0001-7606-8771
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Publications (10 of 241) Show all publications
Riccio, A., Fortin, E., Mellbin, L., Norhammar, A., Näsman, P., Rydén, L., . . . Ferrannini, G. (2024). Sex differences in the association between insulin resistance and non-fatal myocardial infarction across glycaemic states. Cardiovascular Diabetology, 23(1), Article ID 25.
Open this publication in new window or tab >>Sex differences in the association between insulin resistance and non-fatal myocardial infarction across glycaemic states
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2024 (English)In: Cardiovascular Diabetology, E-ISSN 1475-2840, Vol. 23, no 1, article id 25Article in journal (Refereed) Published
Abstract [en]

Background: Females are generally less prone to cardiovascular (CV) events than males, but this protection is trumped by diabetes. The mechanism behind the increased relative risk in females with diabetes is not fully understood. Insulin resistance (IR) is suggested to be a more important contributor to CV morbidity in females than in males. We aim to investigate differences in the association between IR indexes (Homeostatic Model Assessment of IR - HOMA-IR, visceral adiposity index – VAI, and triglycerides/high-density lipoprotein-cholesterol - TG/HDL-C index), and a first non-fatal myocardial infarction (MI) across different glycaemic states. Methods: IR indexes were calculated in a population with (n = 696) and without (n = 707) a first non-fatal MI, free from known diabetes. MI cases were investigated at least six weeks after the event. All participants were categorized by an oral glucose tolerance test as having normal glucose tolerance, impaired fasting glucose, impaired glucose tolerance, or newly diagnosed diabetes. Comparison of proportion of glycaemic states by sex was tested by chi-square test. The associations between sex, a first non-fatal MI, IR indexes, and traditional CV risk factors were analysed by multivariate logistic regression models. Continuous variables were logarithmically transformed. Results: Of the total population 19% were females and 81% males, out of whom 47% and 50% had a first non-fatal MI, respectively. Compared with males, females were older, less often smokers, with lower body mass index and higher total cholesterol and high-density lipoprotein cholesterol levels. The proportion of glycaemic states did not differ between the sexes (p = 0.06). Females were less insulin resistant than males, especially among cases and with normal glucose tolerance. In logistic regression models adjusted for major CV risk factors including sex, the associations between VAI and TG/HDL-C index and a first non-fatal MI remained significant only in females (odds ratios and 95% confidence intervals: 1.7, 1.0-2.9, and 1.9, 1.1–3.4 respectively). Conclusions: These results support the assumption that IR indexes based on anthropometrics and lipid panel, i.e., VAI and TG/HDL-C, could be a better measure of IR and CV-predictor for non-fatal MI in females, even without glycaemic perturbations.

Place, publisher, year, edition, pages
BioMed Central Ltd, 2024
Keywords
Cardiovascular disease, Females, HOMA-IR, PAROKRANK, Prediabetes, Triglycerides/high-density lipoprotein index, Visceral adiposity index
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:kth:diva-342635 (URN)10.1186/s12933-023-02093-y (DOI)001142867000001 ()38218814 (PubMedID)2-s2.0-85182252110 (Scopus ID)
Note

QC 20240125

Available from: 2024-01-25 Created: 2024-01-25 Last updated: 2024-02-01Bibliographically approved
Kang, Y., Abraham, J., Ceccato, V., Duarte, F., Gao, S., Ljungqvist, L., . . . Ratti, C. (2023). Assessing differences in safety perceptions using GeoAI and survey across neighbourhoods in Stockholm, Sweden. Landscape and Urban Planning, 236, 104768-104768, Article ID 104768.
Open this publication in new window or tab >>Assessing differences in safety perceptions using GeoAI and survey across neighbourhoods in Stockholm, Sweden
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2023 (English)In: Landscape and Urban Planning, ISSN 0169-2046, E-ISSN 1872-6062, Vol. 236, p. 104768-104768, article id 104768Article in journal (Refereed) Published
Abstract [en]

The safety perception of the built environment, rather than the sheer number of crimes and incivility behavior, is a fundamental driver of public policies intended to improve urban safety. Traditional surveys often capture neighborhood residents’ perceived safety, but may not fully reflect the perceptions of people who are unfamiliar with the area. In this study, focused on the city of Stockholm, Sweden, we develop a geospatial artificial intelligence (GeoAI) approach using street view images and recruiting locals to create a measure of citywide residents’ safety perceptions. We compare the measures from the survey based on neighborhood residents’ responses with those from the GeoAI approach to better understand the relationship between these safety measures. We model the two forms of safety perceptions and their disparities (i.e., perception bias) as a function of the city’s land use and its socio-demographics. Results confirm that while the GeoAI-based measures better capture people’s instant impressions of the built environment across the city, the survey-based measures reflect their overall daily experiences of specific areas. Regions that appear to be economically vibrant and have inner-city streetscapes are perceived as safe places from visual appearance but are not always perceived as such by residents. Older adults tend to overestimate their likelihood of being victimized by crime, which may enlarge perception bias. The study concludes by critically assessing the potential ethical issues (e.g., spatial bias, population bias) in the proposed methodology and making suggestions for future research.

Place, publisher, year, edition, pages
Elsevier BV, 2023
National Category
Social Sciences
Research subject
Architecture, Urban Design
Identifiers
urn:nbn:se:kth:diva-326752 (URN)10.1016/j.landurbplan.2023.104768 (DOI)000990616100001 ()2-s2.0-85152740824 (Scopus ID)
Note

QC 20230613

Available from: 2023-05-09 Created: 2023-05-09 Last updated: 2023-06-13Bibliographically approved
Ferrannini, G., Fortin, E., Mellbin, L., Norhammar, A., Näsman, P., Smetana, S., . . . Ryden, L. (2023). Empagliflozin improves insulin sensitivity in patients with a recent coronary syndrome and newly detected dysglycaemia. Diabetologia, 66(SUPPL 1), S243-S244
Open this publication in new window or tab >>Empagliflozin improves insulin sensitivity in patients with a recent coronary syndrome and newly detected dysglycaemia
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2023 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 66, no SUPPL 1, p. S243-S244Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Springer Nature, 2023
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:kth:diva-339821 (URN)001065473000477 ()
Note

QC 20231121

Available from: 2023-11-21 Created: 2023-11-21 Last updated: 2023-11-21Bibliographically approved
Fortin, E., Lundin, M., Mellbin, L., Norhammar, A., Näsman, P., Smetana, S., . . . Ferrannini, G. (2023). Empagliflozin improves insulin sensitivity in patients with recent acute coronary syndrome and newly detected dysglycaemia: Experiences from the randomized, controlled SOCOGAMI trial. Cardiovascular Diabetology, 22(1), 208
Open this publication in new window or tab >>Empagliflozin improves insulin sensitivity in patients with recent acute coronary syndrome and newly detected dysglycaemia: Experiences from the randomized, controlled SOCOGAMI trial
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2023 (English)In: Cardiovascular Diabetology, ISSN 1475-2840, E-ISSN 1475-2840, Vol. 22, no 1, p. 208-Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Empagliflozin reduces the risk of cardiovascular disease (CVD) in patients with type 2 diabetes (T2DM) and high cardiovascular risk via mechanisms which have not been fully explained. The mechanisms of such benefit have not been fully understood, and whether empagliflozin can be safely administered as first-line treatment in patients with CVD at the initial stages of glycaemic perturbations remains to be established. We investigated the effects of empagliflozin on insulin resistance, insulin sensitivity and β-cell function indexes in patients with a recent acute coronary event and newly detected dysglycaemia, i.e., impaired glucose tolerance (IGT) or T2DM. METHODS: Forty-two patients (mean age 67.5 years, 19% females) with a recent myocardial infarction (n = 36) or unstable angina (n = 6) and newly detected dysglycaemia were randomized to either empagliflozin 25 mg daily (n = 20) or placebo (n = 22). Patients were investigated with stress-perfusion cardiac magnetic resonance imaging before randomization, 7 months after the start of study drug and 3 months following its cessation. Indexes of insulin resistance, sensitivity and β-cell function were calculated based on glucose and insulin values from 2-hour oral glucose tolerance tests (OGTT) and fasting C-peptide. The differences in glucose, insulin, C-peptide, mannose levels and indexes between the two groups were computed by repeated measures ANOVA including an interaction term between the treatment allocation and the time of visit. RESULTS: After 7 months, empagliflozin significantly decreased glucose and insulin values during the OGTT, whereas C-peptide, mannose and HbA1c did not differ. Empagliflozin significantly improved insulin sensitivity indexes but did not impact insulin resistance and β-cell function. After cessation of the drug, all indexes returned to initial levels. Insulin sensitivity indexes were inversely correlated with left ventricular mass at baseline. CONCLUSIONS: Empagliflozin improved insulin sensitivity indexes in patients with a recent coronary event and drug naïve dysglycaemia. These findings support the safe use of empagliflozin as first-line glucose-lowering treatment in patients at very high cardiovascular risk with newly diagnosed dysglycaemia. TRIAL REGISTRATION NUMBER: EudraCT number 2015-004571-73.

Place, publisher, year, edition, pages
Springer Nature, 2023
Keywords
Cardiac magnetic resonance, Dysglycaemia, Empagliflozin, Insulin resistance, Myocardial infarction
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:kth:diva-334795 (URN)10.1186/s12933-023-01950-0 (DOI)001048288600001 ()37568149 (PubMedID)2-s2.0-85167753938 (Scopus ID)
Note

QC 20230901

Available from: 2023-09-01 Created: 2023-09-01 Last updated: 2023-09-04Bibliographically approved
Fortin, E., Campi, B., Ferrannini, E., Mari, A., Mellbin, L., Norhammar, A., . . . Ferrannini, G. (2023). High mannose correlates with surrogate indexes of insulin resistance and predicts cardiovascular events independently of glycaemic status and traditional risk factors. Diabetologia, 66(SUPPL 1), S493-S493
Open this publication in new window or tab >>High mannose correlates with surrogate indexes of insulin resistance and predicts cardiovascular events independently of glycaemic status and traditional risk factors
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2023 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 66, no SUPPL 1, p. S493-S493Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
SPRINGER, 2023
National Category
Health Sciences
Identifiers
urn:nbn:se:kth:diva-339815 (URN)001065473001370 ()
Note

QC 20231121

Available from: 2023-11-21 Created: 2023-11-21 Last updated: 2023-11-21Bibliographically approved
Fortin, E., Campi, B., Ferrannini, E., Mari, A., Mellbin, L., Norhammar, A., . . . Ferrannini, G. (2023). High mannose correlates with surrogate indexes of insulin resistance and predicts cardiovascular events independently of glycaemic status and traditional risk factors. Paper presented at Annual Meeting of the European-Society-of-Cardiology (ESC), AUG 25-28, 2023, Amsterdam, NETHERLANDS. European Heart Journal, 44
Open this publication in new window or tab >>High mannose correlates with surrogate indexes of insulin resistance and predicts cardiovascular events independently of glycaemic status and traditional risk factors
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2023 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 44Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
OXFORD UNIV PRESS, 2023
National Category
Health Sciences
Identifiers
urn:nbn:se:kth:diva-342334 (URN)001115619402264 ()
Conference
Annual Meeting of the European-Society-of-Cardiology (ESC), AUG 25-28, 2023, Amsterdam, NETHERLANDS
Note

Not duplicate with DiVA 1828213

QC 20240116

Available from: 2024-01-16 Created: 2024-01-16 Last updated: 2024-02-22Bibliographically approved
Riccio, A., Mellbin, L., Norhammar, A., Näsman, P., Ryden, L., Sesti, G. & Ferrannini, G. (2023). Sex differences in the association between insulin resistance indexes and myocardial infarction in individuals with different glycaemic states. Diabetologia, 66(SUPPL 1), S247-S247
Open this publication in new window or tab >>Sex differences in the association between insulin resistance indexes and myocardial infarction in individuals with different glycaemic states
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2023 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 66, no SUPPL 1, p. S247-S247Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Springer Nature, 2023
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:kth:diva-339824 (URN)001065473000485 ()
Note

QC 20231121

Available from: 2023-11-21 Created: 2023-11-21 Last updated: 2023-11-21Bibliographically approved
Nelldal, B.-L., Näsman, P., Han-Suck, S. & Andersson, J. (2022). Förseningarnas påverkan på efterfrågan av tågresor – en tidsserieanalys. Stockholm
Open this publication in new window or tab >>Förseningarnas påverkan på efterfrågan av tågresor – en tidsserieanalys
2022 (Swedish)Report (Other academic)
Abstract [sv]

Förseningar utgör en del av resenärernas uppoffring. Hypotesen är att när förseningarna blir för frekventa och för stora kan det påverka efterfrågan på tågresor. Om resenärerna inte kan lita på tåget finns det en risk att andra färdmedel väljs i stället eller att resandet uteblir. Detta kan tyckas självklart ändå finns det nästan inga kvantitativa analyser av hur mycket förseningarna i tågtrafiken påverkar efterfrågan. Detta projekt syftar till att få fram sådana samband. Med detta projekt går det även att få fram hur andra faktorer påverkar efterfrågan såsom restid, turtäthet och pris vilket också nödvändigt för att kunna särskilja effekten av förseningarna.

Syftet är att hitta samband mellan förseningar och efterfrågan på tågresor d.v.s. hur mycket minskar tågresandet när förseningarna ökar? En metod att få fram detta är att använda tidsserieanalys. Vi har gjort detta genom att kombinera följande data som KTH har tillgång till i kombination med statistiska metoder för tidserieanalys.

·         KTH utbudsdatabas med restider, turtäthet och priser för olika linjer och produkter 1990-2020

·         Trafikverkets databas över förseningar 2001-2020 per linje t.ex. andel tåg i tid inom 5 min och medelförsening

·         Databas från SJ, Trafikhuvudmän och privata operatörer över efterfrågan per linje eller trafiksystem 1990-2020

·         Makroekonomiska data såsom privat konsumtion

·         Befolkningsutveckling längs linjerna

·         Bilinnehav och bensinpriser

Med hjälp av tidserieanalys kan man få fram hur mycket varje faktor bidrar till utvecklingen av efterfrågan på tågresor. Syftet är således att kunna skilja på effekten av kortare restid, ökad turtäthet, ändrade priser och förseningar. För de flesta variabler finns data för perioden 1990-2020 men för förseningar 2001-2020.

Ett stort antal mått på förseningar har tagits fram t.ex. andel försenade tåg inom 5 min (RT+5) och medelförsening för försenade tåg samt andel inställda tåg. Ett nytt mått på har tagits fram i form av antal förseningsminuter per 1000 tågkilometer. Ett stort arbete har lagts ned på att bearbeta förseningsdata från Trafikverkets LUPP-data för att få dem per linje (ca 50 linjer i Sverige) och produkt (snabbtåg, regionaltåg etc.). Bearbetningen visar på stora förseningar under 2010-2011 p.g.a. vinterproblemen och 2018 p.g.a. den varma sommaren. Den bästa punktligheten var det 2004 och 2019 samt 2020. 2020 har dock inte används i tidserieanalysen eftersom efterfrågan var onormal p.g.a. coronapandemin.

Det mått som hittills har gett bäst resultat är medelförsening för tåg som är mer än 5 minuter försenade (RT+5). Med hjälp av tidserieanalys har en elasticitet beräknas mellan medelförsening RT+5 och antalet personkilometer med fjärrtrafik. Elasticiteten blev -0,6 vilket innebär att om medelförseningen ökar med 10% så minskar efterfrågan i personkilometer med 6%. Det innebär t.ex. om ett snabbtåg i medeltal är 20 minuter försenat för RT+5 (typiskt värde för snabbtåg) och medelförseningen ökar till 24 minuter eller med 20% så kommer efterfrågan att minska med 0,6*20=12%. Detta stämmer också väl med de observationer vi har. Med hjälp av den resandestatistik som vi har och ett tidsvärde samt värderingen av förseningstid jämfört med restid (enligt ASEK 3,5) kan man beräkna resenärernas förluster i form av tidskostnad. Den totala kostnaden per år kan också beräknas.

Place, publisher, year, edition, pages
Stockholm: , 2022. p. 100
Series
TRITA-ABE-RPT ; 2221
Keywords
Passenger transports, railway, delays, demand, time serie analyses, Persontrafik, järnväg, förseningar, efterfrågan, tidsserieanalays
National Category
Engineering and Technology Civil Engineering Transport Systems and Logistics
Research subject
Transport Science, Transport Systems; Järnvägsgruppen - Effektiva tågsystem för persontrafik
Identifiers
urn:nbn:se:kth:diva-319476 (URN)
Funder
Swedish Transport Administration
Note

QC 20221003

Available from: 2022-09-29 Created: 2022-09-29 Last updated: 2022-10-03Bibliographically approved
Ferrannini, G., Almosawi, M., Buhlin, K., De Faire, U., Kjellstrom, B., Klinge, B., . . . Norhammar, A. (2022). Long-term prognosis after a first myocardial infarction: eight years follow up of the case-control study PAROKRANK. Scandinavian Cardiovascular Journal, 56(1), 337-342
Open this publication in new window or tab >>Long-term prognosis after a first myocardial infarction: eight years follow up of the case-control study PAROKRANK
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2022 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 56, no 1, p. 337-342Article in journal (Refereed) Published
Abstract [en]

Objective. To explore long-term cardiovascular outcomes and mortality in patients after a first myocardial infarction (MI) compared with matched controls in a contemporary setting. Methods. During 2010-2014 the Swedish study PAROKRANK recruited 805 patients <75 years with a first MI and 805 age-, gender-, and area-matched controls. All study participants were followed until 31 December 2018, through linkage with the National Patient Registry and the Cause of Death Registry. The primary endpoint was the first of a composite of all-cause death, non-fatal MI, non-fatal stroke, and heart failure hospitalization. Event rates in cases and controls were calculated using a Cox regression model, subsequently adjusted for baseline smoking, education level, and marital status. Kaplan-Meier curves were computed and compared by log-rank test. Results. A total of 804 patients and 800 controls (mean age 62 years; women 19%) were followed for a mean of 6.2 (0.2-8.5) years. The total number of primary events was 211. Patients had a higher event rate than controls (log-rank test p < .0001). Adjusted hazard ratio (HR) for the primary outcome was 2.04 (95% CI 1.52-2.73). Mortality did not differ between patients (n = 38; 4.7%) and controls (n = 35; 4.4%). A total of 82.5% patients and 91.3% controls were event-free during the follow up. Conclusions. In this long-term follow up of a contemporary, case-control study, the risk for cardiovascular events was higher in patients with a previous first MI compared with their matched controls, while mortality did not differ. The access to high quality of care and cardiac rehabilitation might partly explain the low rates of adverse outcomes.

Place, publisher, year, edition, pages
Informa UK Limited, 2022
Keywords
Cardiovascular prevention, case-control study, long-term outcome, myocardial infarction, PAROKRANK
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:kth:diva-316946 (URN)10.1080/14017431.2022.2112072 (DOI)000841682000001 ()35974709 (PubMedID)2-s2.0-85136039545 (Scopus ID)
Note

QC 20220912

Available from: 2022-09-01 Created: 2022-09-01 Last updated: 2022-09-12Bibliographically approved
Meziani, S., Ferrannini, G., Bjerre, M., Hansen, T. K., Ritsinger, V., Norhammar, A., . . . Mellbin, L. G. (2022). Mannose-binding lectin does not explain the dismal prognosis after an acute coronary event in dysglycaemic patients: A report from the GAMI cohort. Cardiovascular Diabetology, 21(1), Article ID 129.
Open this publication in new window or tab >>Mannose-binding lectin does not explain the dismal prognosis after an acute coronary event in dysglycaemic patients: A report from the GAMI cohort
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2022 (English)In: Cardiovascular Diabetology, ISSN 1475-2840, E-ISSN 1475-2840, Vol. 21, no 1, article id 129Article in journal (Refereed) Published
Abstract [en]

Background Mannose binding lectin (MBL) has been suggested to be associated with an impaired cardiovascular prognosis in dysglycaemic conditions, but results are still contrasting. Our aims are (i) to examine whether MBL levels differ between patients with an acute myocardial infarction (MI) and healthy controls and between subgroups with different glucose tolerance status, and (ii) to investigate the relation between MBL and future cardiovascular events. Methods MBL levels were assessed at discharge and after 3 months in 161 AMI patients without any previously known glucose perturbations and in 183 age- and gender-matched controls from the Glucose metabolism in patients with Acute Myocardial Infarction (GAMI) study. Participants were classified as having dysglycaemia, i.e. type 2 diabetes or impaired glucose tolerance, or not by an oral glucose tolerance test. The primary outcome was a composite of cardiovascular events comprising cardiovascular death, AMI, stroke or severe heart failure during 11 years of follow-up. Total and cardiovascular mortality served as secondary outcomes. Results At hospital discharge patients had higher MBL levels (median 1246 mu g/L) than three months later (median 575 mu g/L; p < 0.01), the latter did not significantly differ from those in the controls (801 mu g/L; p = 0.47). MBL levels were not affected by dysglycaemia either in patients or controls. Independent of glycaemic state, increasing MBL levels did not predict any of the studied outcomes in patients. In unadjusted analyses increasing MBL levels predicted cardiovascular events (hazard ratio HR: 1.67, 95% confidence interval CI 1.06-2.64) and total mortality (HR 1.53, 95% CI 1.12-2.10) in the control group. However, this did not remain in adjusted analyses. Conclusions Patients had higher MBL levels than controls during the hospital phase of AMI, supporting the assumption that elevated MBL reflects acute stress. MBL was not found to be independently associated with cardiovascular prognosis in patients with AMI regardless of glucose state.

Place, publisher, year, edition, pages
Springer Nature, 2022
Keywords
Dysglycaemia, Cardiovascular disease, Inflammation, Complement system proteins, Mannose binding lectin, Biomarker, Prognosis
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:kth:diva-315841 (URN)10.1186/s12933-022-01562-0 (DOI)000822341600001 ()35804351 (PubMedID)2-s2.0-85133662189 (Scopus ID)
Note

QC 20220721

Available from: 2022-07-21 Created: 2022-07-21 Last updated: 2022-07-21Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-7606-8771

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