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Hedberg, Yolanda, DocentORCID iD iconorcid.org/0000-0003-2145-3650
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Publications (10 of 56) Show all publications
Wei, Z., Edin, J., Karlsson, A. E., Petrovic, K., Soroka, I. L., Odnevall Wallinder, I. & Hedberg, Y. (2018). Can gamma irradiation during radiotherapy influence the metal release process for biomedical CoCrMo and 316L alloys?. Journal of Biomedical Materials Research. Part B - Applied biomaterials
Open this publication in new window or tab >>Can gamma irradiation during radiotherapy influence the metal release process for biomedical CoCrMo and 316L alloys?
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2018 (English)In: Journal of Biomedical Materials Research. Part B - Applied biomaterials, ISSN 1552-4973, E-ISSN 1552-4981Article in journal (Refereed) Epub ahead of print
Abstract [en]

The extent of metal release from implant materials that are irradiated during radiotherapy may be influenced by irradiation-formed radicals. The influence of gamma irradiation, with a total dose of relevance for radiotherapy (e.g., for cancer treatments) on the extent of metal release from biomedical stainless steel AISI 316L and a cobalt-chromium alloy (CoCrMo) was investigated in physiological relevant solutions (phosphate buffered saline with and without 10 g/L bovine serum albumin) at pH 7.3. Directly after irradiation, the released amounts of metals were significantly higher for irradiated CoCrMo as compared to nonirradiated CoCrMo, resulting in an increased surface passivation (enhanced passive conditions) that hindered further release. A similar effect was observed for 316L showing lower nickel release after 1 h of initially irradiated samples as compared to nonirradiated samples. However, the effect of irradiation (total dose of 16.5 Gy) on metal release and surface oxide composition and thickness was generally small. Most metals were released initially (within seconds) upon immersion from CoCrMo but not from 316L. Albumin induced an increased amount of released metals from AISI 316L but not from CoCrMo. Albumin was not found to aggregate to any greater extent either upon gamma irradiation or in the presence of trace metal ions, as determined using different light scattering techniques. Further studies should elucidate the effect of repeated friction and fractionated low irradiation doses on the short- and long term metal release process of biomedical materials.

Keywords
BSA, implant, passivation, radicals, radiotherapy
National Category
Occupational Health and Environmental Health Corrosion Engineering
Identifiers
urn:nbn:se:kth:diva-225956 (URN)10.1002/jbm.b.34084 (DOI)29424962 (PubMedID)
Funder
Swedish Research Council, 2015–04177
Note

QC 20180611

Available from: 2018-04-11 Created: 2018-04-11 Last updated: 2018-06-11Bibliographically approved
Hedberg, Y., Erfani, B., Matura, M. & Lidén, C. (2018). Chromium(III) release from chromium-tanned leather elicits allergic contact dermatitis: a use test study.. Contact Dermatitis, 78(5), 307-314
Open this publication in new window or tab >>Chromium(III) release from chromium-tanned leather elicits allergic contact dermatitis: a use test study.
2018 (English)In: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 78, no 5, p. 307-314Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Chromium (Cr) is a common skin sensitizer. The use of Cr(VI) in leather is restricted in the EU, but that of Cr(III) is not.

OBJECTIVES: To assess whether prolonged exposure to Cr-tanned leather with mainly Cr(III) release may elicit allergic contact dermatitis in Cr-allergic individuals.

METHOD: Ten Cr-allergic subjects and 22 controls were patch tested with serial dilutions of Cr(III) and Cr(VI), and with leather samples. They then conducted a use test with a Cr-tanned and a Cr-free leather bracelet over a period of 3 weeks, for 12 h per day. Cr deposited on the skin from the bracelets was measured in the controls, and the diphenylcarbazide test for Cr(VI) and extraction tests for Cr(III) and Cr(VI) were conducted for the different leathers.

RESULTS: Four of 10 Cr-allergic subjects developed positive reactions to the Cr-tanned bracelet within 7-21 days, whereas only 1 of 10 had a positive patch test reaction to this leather. Cr released from the Cr-tanned leather was most probably entirely Cr(III), with a quantifiable amount being deposited on the skin.

CONCLUSIONS: This study strongly suggests that prolonged and repeated exposure to Cr-tanned leather with mainly Cr(III) release is capable of eliciting allergic contact dermatitis in Cr-allergic individuals.

Keywords
allergic contact dermatitis, chromium, leather, skin exposure assessment, use test
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:kth:diva-225955 (URN)10.1111/cod.12946 (DOI)000428991800001 ()29322530 (PubMedID)2-s2.0-85040509202 (Scopus ID)
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare
Note

QC 20180530

Available from: 2018-04-11 Created: 2018-04-11 Last updated: 2018-05-30Bibliographically approved
Lebedova, J., Hedberg, Y., Odnevall Wallinder, I. & Karlsson, H. L. (2018). Size-dependent genotoxicity of silver, gold and platinum nanoparticles studied using the mini-gel comet assay and micronucleus scoring with flow cytometry. Mutagenesis, 33(1), 77-85
Open this publication in new window or tab >>Size-dependent genotoxicity of silver, gold and platinum nanoparticles studied using the mini-gel comet assay and micronucleus scoring with flow cytometry
2018 (English)In: Mutagenesis, ISSN 0267-8357, E-ISSN 1464-3804, Vol. 33, no 1, p. 77-85Article in journal (Refereed) Published
Abstract [en]

Metallic nanoparticles (NPs) are promising nanomaterials used in different technological solutions as well as in consumer products. Silver (Ag), gold (Au) and platinum (Pt) represent three metallic NPs with current or suggested use in different applications. Pt is also used as vehicle exhaust catalyst leading to a possible exposure via inhalation. Despite their use, there is limited data on their genotoxic potential and possible size-dependent effects, particularly for Pt NPs. The aim of this study was to explore size-dependent genotoxicity of these NPs (5 and 50 nm) following exposure of human bronchial epithelial cells. We characterised the NPs and assessed the viability (Alamar blue assay), formation of DNA strand breaks (mini-gel comet assay) and induction of micronucleus (MN) analysed using flow cytometry (in vitro microflow kit). The results confirmed the primary size (5 and 50 nm) but showed agglomeration of all NPs in the serum free medium used. Slight reduced cell viability (tested up to 50 mu g/ml) was observed following exposure to the Ag NPs of both particle sizes as well as to the smallest (5 nm) Au NPs. Similarly, at non-cytotoxic concentrations, both 5 and 50 nm-sized Ag NPs, as well as 5 nm-sized Au NPs, increased DNA strand breaks whereas for Pt NPs only the 50 nm size caused a slight increase in DNA damage. No clear induction of MN was observed in any of the doses tested (up to 20 mu g/ml). Taken together, by using the comet assay our study shows DNA strand breaks induced by Ag NPs, without any obvious differences in size, whereas effects from Au and Pt NPs were size-dependent in the sense that the 5 nm-sized Au NPs and 50 nm-sized Pt NPs particles were active. No clear induction of MN was observed for the NPs.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS, 2018
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:kth:diva-225329 (URN)10.1093/mutage/gex027 (DOI)000426079100011 ()2-s2.0-85042721477 (Scopus ID)
Note

QC 20180403

Available from: 2018-04-03 Created: 2018-04-03 Last updated: 2018-04-03Bibliographically approved
Mei, N., Belleville, L., Cha, Y., Olofsson, U., Odnevall Wallinder, I., Persson, K.-A. -. & Hedberg, Y. (2018). Size-separated particle fractions of stainless steel welding fume particles – A multi-analytical characterization focusing on surface oxide speciation and release of hexavalent chromium. Journal of Hazardous Materials, 342, 527-535
Open this publication in new window or tab >>Size-separated particle fractions of stainless steel welding fume particles – A multi-analytical characterization focusing on surface oxide speciation and release of hexavalent chromium
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2018 (English)In: Journal of Hazardous Materials, ISSN 0304-3894, E-ISSN 1873-3336, Vol. 342, p. 527-535Article in journal (Refereed) Published
Abstract [en]

Welding fume of stainless steels is potentially health hazardous. The aim of this study was to investigate the manganese (Mn) and chromium (Cr) speciation of welding fume particles and their extent of metal release relevant for an inhalation scenario, as a function of particle size, welding method (manual metal arc welding, metal arc welding using an active shielding gas), different electrodes (solid wires and flux-cored wires) and shielding gases, and base alloy (austenitic AISI 304L and duplex stainless steel LDX2101). Metal release investigations were performed in phosphate buffered saline (PBS), pH 7.3, 37°, 24 h. The particles were characterized by means of microscopic, spectroscopic, and electroanalytical methods. Cr was predominantly released from particles of the welding fume when exposed in PBS [3–96% of the total amount of Cr, of which up to 70% as Cr(VI)], followed by Mn, nickel, and iron. Duplex stainless steel welded with a flux-cored wire generated a welding fume that released most Cr(VI). Nano-sized particles released a significantly higher amount of nickel compared with micron-sized particle fractions. The welding fume did not contain any solitary known chromate compounds, but multi-elemental highly oxidized oxide(s) (iron, Cr, and Mn, possibly bismuth and silicon). 

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Chromium(VI), Flux-cored wire, Manganese, Nickel, Welding
National Category
Materials Engineering
Identifiers
urn:nbn:se:kth:diva-216800 (URN)10.1016/j.jhazmat.2017.08.070 (DOI)000414880800057 ()28886565 (PubMedID)2-s2.0-85028707249 (Scopus ID)
Funder
VINNOVA, 2017-02519
Note

QC 20171205

Available from: 2017-11-14 Created: 2017-11-14 Last updated: 2017-12-05Bibliographically approved
Hedberg, Y., Karlsson, M.-E. -., Wei, Z., Znidarsic, M., Odnevall Wallinder, I. & Hedberg, J. (2017). Interaction of Albumin and Fibrinogen with Stainless Steel: Influence of Sequential Exposure and Protein Aggregation on Metal Release and Corrosion Resistance. Corrosion, 73(12)
Open this publication in new window or tab >>Interaction of Albumin and Fibrinogen with Stainless Steel: Influence of Sequential Exposure and Protein Aggregation on Metal Release and Corrosion Resistance
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2017 (English)In: Corrosion, ISSN 0010-9312, E-ISSN 1938-159X, Vol. 73, no 12Article in journal (Refereed) Published
Abstract [en]

Corrosion and metal release mechanisms of the biomedical stainless steel grade Type 316L are at human-relevant biological conditions not fully understood. This study focuses on its corrosion properties and release of iron (Fe), chromium (Cr), manganese (Mn), and nickel (Ni) into simulated physiological solutions at pH 7.4 in the presence of proteins. Parallel studies were performed on stainless steel Type 303 containing a substantial amount of MnS inclusions. Metal release studies were performed in phosphate buffered saline (PBS) for 4 h and 24 h at 37 degrees C with or without different concentrations of bovine serum albumin (BSA), fibrinogen from bovine plasma (Fbn), or mixtures of the same. Studies were in addition performed after 1, 4, 6, and 24 h in solutions that were partially replenished after 5 h in order to investigate whether any Vroman effect (exchange of adsorbed proteins by proteins of higher binding affinity) could influence the extent of released metals in solution. This was performed at physiological concentrations of BSA (40 g/L) and Fbn (2.67 g/L) in PBS, and for reference solutions of PBS, PBS with 40 g/L BSA, and PBS with 2.67 g/L Fbn. Changes in open-circuit potential and linear polarization resistance were investigated for the same conditions. After exposure, the exposed surfaces were rinsed and investigated ex situ by means of x-ray photoelectron spectroscopy and infrared reflection absorption spectroscopy. Metal-protein complexation-induced metal release mechanisms were found to be most pronounced for Type 316L and the release of Fe, Cr, and Ni. Fibrinogen adsorbed differently onto Type 303 (thicker conformation of adsorbed proteins) as compared with Type 316L and occasionally induced corrosion events for Type 303. Mn was mostly released from inclusions present in the Type 303 alloy, most probably via non-electrochemical mechanisms. A Vroman effect was observed for both grades. A significant extent of precipitation of metal-rich protein aggregates influenced the metal release measurements in solution and resulted in an underestimation of the total amount of released metals from the stainless steel grades.

Place, publisher, year, edition, pages
NATL ASSOC CORROSION ENG, 2017
Keywords
albumin, corrosion resistance, fibrinogen, metal release, Vroman
National Category
Chemical Sciences
Identifiers
urn:nbn:se:kth:diva-217929 (URN)10.5006/2504 (DOI)000414329600005 ()
Note

QC 20171121

Available from: 2017-11-21 Created: 2017-11-21 Last updated: 2017-11-21Bibliographically approved
Hedberg, Y., Hedberg, J., Isaksson, S., Mei, N., Blomberg, E., Wold, S. & Odnevall Wallinder, I. (2017). Nanoparticles of WC-Co, WC, Co and Cu of relevance for traffic wear particles – Particle stability and reactivity in synthetic surface water and influence of humic matter. Environmental Pollution, 224, 275-288
Open this publication in new window or tab >>Nanoparticles of WC-Co, WC, Co and Cu of relevance for traffic wear particles – Particle stability and reactivity in synthetic surface water and influence of humic matter
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2017 (English)In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 224, p. 275-288Article in journal (Refereed) Published
Abstract [en]

Studded tyres made of tungsten carbide cobalt (WC-Co) are in the Northern countries commonly used during the winter time. Tungsten (W)-containing nano- and micron-sized particles have been detected close to busy roads in several European countries. Other typical traffic wear particles consist of copper (Cu). The aims of this study were to investigate particle stability and transformation/dissolution properties of nanoparticles (NPs) of WC-Co compared with NPs of tungsten carbide (WC), cobalt (Co), and Cu. Their physicochemical characteristics (primarily surface oxide and charge) are compared with their extent of sedimentation and metal release in synthetic surface water (SW) with and without two different model organic molecules, 2,3- and 3,4-dihydroxybenzoic acid (DHBA) mimicking certain sorption sites of humic substances, for time periods up to 22 days. The WC-Co NPs possessed a higher electrochemical and chemical reactivity in SW with and without DHBA molecules as compared with NPs of WC, Co, and Cu. Co was completely released from the WC-Co NPs within a few hours of exposure, although it remained adsorbed/bonded to the particle surface and enabled the adsorption of negatively charged DHBA molecules, in contrast with the WC NPs (no adsorption of DHBA). The DHBA molecules were found to rapidly adsorb on the Co and Cu NPs. The sedimentation of the WC and WC-Co NPs was not influenced by the presence of the 2,3- or 3,4-DHBA molecules. A slight influence (slower sedimentation) was observed for the Co NPs, and a strong influence (slower sedimentation) was observed for the Cu NPs in SW with 2,3-DHBA compared with SW alone. The extent of metal release increased in the order: WC < Cu < Co < WC-Co NPs. All NPs released more than 1 wt-% of their metal total mass. The release from the Cu NPs was most influenced by the presence of DHBA molecules.

Place, publisher, year, edition, pages
Elsevier, 2017
Keywords
Cobalt, Copper, Metal release, Nanoparticles, Tungsten, Metal nanoparticles, Metals, Molecules, Sedimentation, Tungsten alloys, Tungsten carbide, 3, 4-Dihydroxybenzoic acids, Micron-sized particles, Nanoparticle (NPs), Negatively charged, Physicochemical characteristics, Synthetic surfaces, Tungsten carbide cobalt, Surface waters
National Category
Chemical Sciences
Identifiers
urn:nbn:se:kth:diva-207343 (URN)10.1016/j.envpol.2017.02.006 (DOI)000399261400026 ()2-s2.0-85011949542 (Scopus ID)
Note

QC 20170607

Available from: 2017-06-07 Created: 2017-06-07 Last updated: 2017-11-13Bibliographically approved
Cha, Y., Hedberg, Y., Mei, N. & Olofsson, U. (2016). Airborne Wear Particles Generated from Conductor Rail and Collector Shoe Contact: Influence of Sliding Velocity and Particle Size. Tribology letters, 64(3), Article ID 40.
Open this publication in new window or tab >>Airborne Wear Particles Generated from Conductor Rail and Collector Shoe Contact: Influence of Sliding Velocity and Particle Size
2016 (English)In: Tribology letters, ISSN 1023-8883, E-ISSN 1573-2711, Vol. 64, no 3, article id 40Article in journal (Refereed) Published
Abstract [en]

The mechanical wear of train components is one of the main sources of airborne particles in subway air. A certain contribution is suspected to derive from third-rail systems due to the sliding of two metallic surfaces between conductor rail and collector shoe during operation. In this study, a pin-on-disc apparatus was used to simulate the friction between such two sliding partners (shoe-to-rail). Airborne particles generated from the sliding contact were measured by particle counters (a fast mobility particle sizer spectrometer and an optical particle sizer) and were collected by an electrical low-pressure impactor for physical and chemical analysis. Interface temperature for each test was measured by a thermocouple. The influence of sliding velocity and temperature on particulate number concentration, size distribution, and chemical composition was investigated. Atomic absorption spectroscopy, cyclic voltammetry, and energy-dispersive spectroscopy measurements were carried out to determine the chemical compositions. Results show that increasing sliding velocity results in a higher temperature at the frictional interface and a higher concentration of ultrafine particles. The ratio of manganese to iron surface oxides increased strongly with smaller particle size. A copper compound was observed in some particle samples, probably gerhardite (Cu2NO3(OH)(3)) formed due to high temperature.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2016
Keywords
Sliding wear, Third-rail tribology, Particle emissions, Airborne wear particle, Oxidative wear
National Category
Applied Mechanics
Identifiers
urn:nbn:se:kth:diva-199514 (URN)10.1007/s11249-016-0775-7 (DOI)000389604800008 ()2-s2.0-84993992738 (Scopus ID)
Note

QC 20170117

Available from: 2017-01-17 Created: 2017-01-09 Last updated: 2017-11-29Bibliographically approved
Hedberg, Y. S., Liden, C. & Lindberg, M. (2016). Chromium Dermatitis in a Metal Worker Due to Leather Gloves and Alkaline Coolant. Acta Dermato-Venereologica, 96(1), 104-105
Open this publication in new window or tab >>Chromium Dermatitis in a Metal Worker Due to Leather Gloves and Alkaline Coolant
2016 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 96, no 1, p. 104-105Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Acta Dermato-Venereologica, 2016
National Category
Dermatology and Venereal Diseases
Identifiers
urn:nbn:se:kth:diva-182789 (URN)10.2340/00015555-2160 (DOI)000368870700021 ()2-s2.0-85018224001 (Scopus ID)
Note

QC 20160223

Available from: 2016-02-23 Created: 2016-02-23 Last updated: 2018-09-19Bibliographically approved
Hedberg, Y. S. & Odnevall Wallinder, I. (2016). Metal release from stainless steel in biological environments: A review. Biointerphases, 11(1), Article ID 018901.
Open this publication in new window or tab >>Metal release from stainless steel in biological environments: A review
2016 (English)In: Biointerphases, ISSN 1934-8630, E-ISSN 1559-4106, Vol. 11, no 1, article id 018901Article, review/survey (Refereed) Published
Abstract [en]

Due to its beneficial corrosion resistance, stainless steel is widely used in, e.g., biomedical applications, as surfaces in food contact, and for products intended to come into skin contact. Low levels of metals can be released from the stainless steel surface into solution, even for these highly corrosion resistant alloys. This needs to be considered in risk assessment and management. This review aims to compile the different metal release mechanisms that are relevant for stainless steel when used in different biological settings. These mechanisms include corrosion-induced metal release, dissolution of the surface oxide, friction-induced metal release, and their combinations. The influence of important physicochemical surface properties, different organic species and proteins in solution, and of biofilm formation on corrosion-induced metal release is discussed. Chemical and electrochemical dissolution mechanisms of the surface oxides of stainless steel are presented with a focus on protonation, complexation/ligand-induced dissolution, and reductive dissolution by applying a perspective on surface adsorption of complexing or reducing ligands and proteins. The influence of alloy composition, microstructure, route of manufacture, and surface finish on the metal release process is furthermore discussed as well as the chemical speciation of released metals. Typical metal release patterns are summarized.

Place, publisher, year, edition, pages
American Institute of Physics (AIP), 2016
Keywords
Metal surfaces, Oxide surfaces, Corrosion, Nickel, Surface finishing
National Category
Corrosion Engineering Manufacturing, Surface and Joining Technology
Identifiers
urn:nbn:se:kth:diva-177000 (URN)10.1116/1.4934628 (DOI)000374982200016 ()26514345 (PubMedID)2-s2.0-84954415568 (Scopus ID)
Funder
Swedish Research Council, 2013-5621Forte, Swedish Research Council for Health, Working Life and Welfare, 2013-0054
Note

QC 20151116

Available from: 2015-11-16 Created: 2015-11-13 Last updated: 2017-12-01Bibliographically approved
Hedberg, Y., Herting, G., Latvala, S., Elihn, K., Karlsson, H. L. & Odnevall Wallinder, I. (2016). Surface passivity largely governs the bioaccessibility of nickel-based powder particles at human exposure conditions. Regulatory toxicology and pharmacology, 81, 162-170
Open this publication in new window or tab >>Surface passivity largely governs the bioaccessibility of nickel-based powder particles at human exposure conditions
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2016 (English)In: Regulatory toxicology and pharmacology, ISSN 0273-2300, E-ISSN 1096-0295, Vol. 81, p. 162-170Article in journal (Refereed) Published
Abstract [en]

The European chemical framework REACH requires that hazards and risks posed by chemicals, including alloys and metals, are identified and proven safe for humans and the environment. Therefore, differences in bioaccessibility in terms of released metals in synthetic biological fluids (different pH (1.5–7.4) and composition) that are relevant for different human exposure routes (inhalation, ingestion, and dermal contact) have been assessed for powder particles of an alloy containing high levels of nickel (Inconel 718, 57 wt% nickel). This powder is compared with the bioaccessibility of two nickel-containing stainless steel powders (AISI 316L, 10–12% nickel) and with powders representing their main pure alloy constituents: two nickel metal powders (100% nickel), two iron metal powders and two chromium metal powders. X-ray photoelectron spectroscopy, microscopy, light scattering, and nitrogen absorption were employed for the particle and surface oxide characterization. Atomic absorption spectroscopy was used to quantify released amounts of metals in solution. Cytotoxicity (Alamar blue assay) and DNA damage (comet assay) of the Inconel powder were assessed following exposure of the human lung cell line A549, as well as its ability to generate reactive oxygen species (DCFH-DA assay). Despite its high nickel content, the Inconel alloy powder did not release any significant amounts of metals and did not induce any toxic response. It is concluded, that this is related to the high surface passivity of the Inconel powder governed by its chromium-rich surface oxide. Read-across from the pure metal constituents is hence not recommended either for this or any other passive alloy.

Place, publisher, year, edition, pages
Academic Press, 2016
Keywords
Alloy, Bioaccessibility, Inconel, Nickel, Toxicity
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:kth:diva-195212 (URN)10.1016/j.yrtph.2016.08.013 (DOI)000389865600019 ()2-s2.0-84984813653 (Scopus ID)
Note

QC 21061118

Available from: 2016-11-18 Created: 2016-11-02 Last updated: 2018-01-13Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0003-2145-3650

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