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Erlandsson, Björn-ErikORCID iD iconorcid.org/0000-0002-1929-135X
Publications (10 of 29) Show all publications
Fatemi, A., Erlandsson, B.-E., Emrani, Z., Etehadtavakol, M., Smiley, A. & Karbalaie, A. (2019). Nailfold microvascular changes in patients with systemic lupus erythematosus and their associative factors. Microvascular Research, 126, Article ID UNSP 103910.
Open this publication in new window or tab >>Nailfold microvascular changes in patients with systemic lupus erythematosus and their associative factors
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2019 (English)In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319, Vol. 126, article id UNSP 103910Article in journal (Refereed) Published
Abstract [en]

Objectives: The aim of this study was to determine capillaroscopic changes in patients with systemic lupus erythematosus (SLE) and their predictors. Methods: Fifty-nine SLE patients and 31 controls were enrolled in a cross-sectional study. Nailfold capillaroscopy examinations were performed, and qualitative semi-quantitative and quantitative parameters were evaluated in all fingers. Demographic features and lupus characteristics, such as renal involvement, medications, laboratory data, disease activity (SLEDAI) and damage, were recorded. The predictors of capillaroscopic abnormalities were obtained by backward stepwise regression analysis. Results: Capillary numbers of right hands were significantly lower in patients than in controls [8.74 (1.66) vs. 9.63 (1.80), P = 0.0001]. Capillaries were wider in patients than in controls in right [56.32 pm (16.76) vs. 50.43 mu m (10.16), P = 0.002] and left hands [54.40 (15.02) vs. 49.71 (9.77), P = 0.005]. Capillaries were shorter in SLE patients than in controls. Multivariate analysis revealed that the main associative factors of microvascular abnormalities were gender, drinking tea and hydroxychloroquine use for giant capillaries, SLEDAI and low C3 for avascularity and age, lupus nephritis and corticosteroid use for ramification. Conclusion: Most nailfold capillaroscopic abnormalities were more common in SLE patients than in controls. Hydroxychloroquine, corticosteroids, SLEDAI, low complement and lupus nephritis may be the major prognostic factors for microvascular changes in SLE patients.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019
Keywords
Nailfold video capillaroscopy, Systemic lupus erythematosus, Microcirculation
National Category
Clinical Medicine
Identifiers
urn:nbn:se:kth:diva-260985 (URN)10.1016/j.mvr.2019.103910 (DOI)000485206200009 ()31408627 (PubMedID)2-s2.0-85070793764 (Scopus ID)
Note

QC 20191008

Available from: 2019-10-08 Created: 2019-10-08 Last updated: 2019-10-16Bibliographically approved
Karbalaie, A., Emrani, Z., Fatemi, A., Etehadtavakol, M. & Erlandsson, B.-E. (2019). Practical issues in assessing nailfold capillaroscopic images: a summary. Clinical Rheumatology, 38(9), 2343-2354
Open this publication in new window or tab >>Practical issues in assessing nailfold capillaroscopic images: a summary
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2019 (English)In: Clinical Rheumatology, ISSN 0770-3198, E-ISSN 1434-9949, Vol. 38, no 9, p. 2343-2354Article, review/survey (Refereed) Published
Abstract [en]

Nailfold capillaroscopy (NC) is a highly sensitive, safe, and non-invasive technique to assess involvement rate of microvascularity in dermatomyositis and systemic sclerosis. A large number of studies have focused on NC pattern description, classification, and scoring system validation, but minimal information has been published on the accuracy and precision of the measurement. The objective of this review article is to identify different factors affecting the reliability and validity of the assessment in NC. Several factors can affect the reliability of the examination, e.g., physiological artifacts, the nailfold imaging instrument, human factors, and the assessment rules and standards. It is impossible to avoid all artifacts, e.g., skin transparency, physically injured fingers, and skin pigmentation. However, minimization of the impact of some of these artifacts by considering some protocols before the examination and by using specialized tools, training, guidelines, and software can help to reduce errors in the measurement and assessment of NC images. Establishing guidelines and instructions for automatic characterization and measurement based on machine learning techniques also may reduce ambiguities and the assessment time.

Place, publisher, year, edition, pages
SPRINGER LONDON LTD, 2019
Keywords
Assessment, Measurement, Nailfold capillaroscopy
National Category
Clinical Medicine
Identifiers
urn:nbn:se:kth:diva-260182 (URN)10.1007/s10067-019-04644-9 (DOI)000483770400007 ()31278512 (PubMedID)2-s2.0-85068831307 (Scopus ID)
Note

QC 20190927

Available from: 2019-09-27 Created: 2019-09-27 Last updated: 2019-09-27Bibliographically approved
Karbalaie, A., Etehadtavakol, M., Abtahi, F., Fatemi, A., Emrani, Z. & Erlandsson, B.-E. (2018). Image Enhancement Effect on Inter and Intra-observer Reliability of Nailfold Capillary Assessment. Microvascular Research
Open this publication in new window or tab >>Image Enhancement Effect on Inter and Intra-observer Reliability of Nailfold Capillary Assessment
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2018 (English)In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319Article in journal (Refereed) Published
Abstract [en]

Background: Nailfold capillaroscopy (NC) is a diagnostic imaging technique that is used to assess the blood capillary network in the nailfold area. NC is routinely used for patients with microcirculation problems, such as systemic sclerosis and other connective tissue diseases.  Experts commonly use subjective evaluation as a reference point in images of nailfold video capillaroscopy, so it is important to reduce the inherent ambiguities in human judgment and diagnosis. Image quality is an important factor that affects measurement error and assessment time of NC images.

Objective: In this study, a new image enhancement technique was introduced and evaluated subjectively.

Methods: In total, 475 nailfold video capillaroscopy images from 18 healthy subjects and 41 systemic lupus erythematosus patients were used. The images were randomly divided into two sets, one each with 275 and 200. Eight independent observers who were familiar with the capillaroscopy technique participated in this study. The set of 275 images was evaluated by three observers with the forced–choice pairwise comparison method. Elliptic broken line (EBL) was used to count the number of capillaries. The intra- and inter-observer reliability of the original and enhanced images was evaluated on 200 images by five observers.

Result: Except for eight images, all observers preferred the enhanced images in the visual quality comparison method. The intra-class correlation coefficient (ICC) of intra- and inter-observer reliability increased from 0.76-0.84 to 0.82-0.89, respectively, when using the enhancement method.

Conclusion: By improving the image quality, more capillary details will be visible, and an observer can document more details that may not be visible in the original image and can do so more efficiently.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Nailfold capillaroscopy; Image enhancement; Inter and intra-observer reliability; Capillary density; Systemic lupus erythematosus
National Category
Medical and Health Sciences
Research subject
Medical Technology
Identifiers
urn:nbn:se:kth:diva-231959 (URN)10.1016/j.mvr.2018.06.005 (DOI)000449037600016 ()2-s2.0-85051111896 (Scopus ID)
Note

QC 20180821

Available from: 2018-07-05 Created: 2018-07-05 Last updated: 2018-11-20Bibliographically approved
Elinder, G., Eriksson, A., Hallberg, B., Lynoe, N., Sundgren, P. M., Rosen, M., . . . Erlandsson, B.-E. (2018). Traumatic shaking: The role of the triad in medical investigations of suspected traumatic shaking. Acta Paediatrica, 107, 3-23
Open this publication in new window or tab >>Traumatic shaking: The role of the triad in medical investigations of suspected traumatic shaking
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2018 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, p. 3-23Article, review/survey (Refereed) Published
Abstract [en]

The Swedish Agency for Health Technology Assessment and Assesment of Social Services (SBU) is an independent national authority, tasked by the government with assessing methods used in health, medical and dental services and social service interventions from a broad perspective, covering medical, economic, ethical and social aspects. The language in SBU's reports are adjusted to a wide audience. SBU's Board of Directors has approved the conclusions in this report. The systematic review showed the following graded results: There is limited scientific evidence that the triad (Three components of a whole. The triad associated with SBS usually comprises subdural haematoma, retinal haemorrhages and encephalopathy.) and therefore, its components can be associated with traumatic shaking (low-quality evidence). There is insufficient scientific evidence on which to assess the diagnostic accuracy of the triad in identifying traumatic shaking (very low-quality evidence). Limited scientific evidence (low-quality evidence) represents a combined assessment of studies of high or moderate quality which disclose factors that markedly weaken the evidence. It is important to note that limited scientific evidence for the reliability of a method or an effect does not imply complete lack of scientific support. Insufficient scientific evidence (very low-quality evidence) represents either a lack of studies or situations when available studies are of low quality or show contradictory results. Evaluation of the evidence was not based on formal grading of the evidence according to GRADE but on an evaluation of the total scientific basis.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2018
Keywords
Brain oedema, Child abuse, Infant, Retinal haemorrhage, Shaken Baby Syndrome, Subdural haematoma
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:kth:diva-234571 (URN)10.1111/apa.14473 (DOI)000442730400001 ()30146789 (PubMedID)2-s2.0-85052239909 (Scopus ID)
Note

QC 20180917

Available from: 2018-09-17 Created: 2018-09-17 Last updated: 2018-09-17Bibliographically approved
Karbalaie, A., Abtahi, F., Fatemi, A., Etehadtavakol, M., Emrani, Z. & Erlandsson, B.-E. (2017). Elliptical broken line method for calculating capillary density in nailfold capillaroscopy: Proposal and evaluation. Microvascular Research, 113, 1-8
Open this publication in new window or tab >>Elliptical broken line method for calculating capillary density in nailfold capillaroscopy: Proposal and evaluation
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2017 (English)In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319, Vol. 113, p. 1-8Article in journal (Refereed) Published
Abstract [en]

Nailfold capillaroscopy is a practical method for identifying and obtaining morphological changes in capillaries which might reveal relevant information about diseases and health. Capillaroscopy is harmless, and seems simple and repeatable. However, there is lack of established guidelines and instructions for acquisition as well as the interpretation of the obtained images; which might lead to various ambiguities. In addition, assessment and interpretation of the acquired images are very subjective. In an attempt to overcome some of these problems, in this study a new modified technique for assessment of nailfold capillary density is introduced. The new method is named elliptic broken line (EBL) which is an extension of the two previously known methods by defining clear criteria for finding the apex of capillaries in different scenarios by using a fitted elliptic. A graphical user interface (GUI) is developed for pre-processing, manual assessment of capillary apexes and automatic correction of selected apexes based on 90° rule. Intra- and inter-observer reliability of EBL and corrected EBL is evaluated in this study. Four independent observers familiar with capillaroscopy performed the assessment for 200 nailfold videocapillaroscopy images, form healthy subject and systemic lupus erythematosus patients, in two different sessions. The results show elevation from moderate (ICC = 0.691) and good (ICC = 0.753) agreements to good (ICC = 0.750) and good (ICC = 0.801) for intra- and inter-observer reliability after automatic correction of EBL. This clearly shows the potential of this method to improve the reliability and repeatability of assessment which motivates us for further development of automatic tool for EBL method.

Place, publisher, year, edition, pages
Academic Press, 2017
Keywords
Capillary density, Nailfold capillaroscopy, Number of papillae, Reliability, Repeatability
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:kth:diva-207279 (URN)10.1016/j.mvr.2017.04.002 (DOI)000404692200001 ()28414021 (PubMedID)2-s2.0-85017510457 (Scopus ID)
Note

QC 20170619

Available from: 2017-06-19 Created: 2017-06-19 Last updated: 2018-11-20Bibliographically approved
Karbalaie, A., Fatemi, A., Etehadtavakol, M., Abtahi, F., Emrani, Z. & Erlandsson, B.-E. (2016). Counting Capillaries in Nailfold Capillaroscopy:State of the Art and a Proposed Method. In: 2016 IEEE EMBS CONFERENCE ON BIOMEDICAL ENGINEERING AND SCIENCES (IECBES): . Paper presented at Conference on Biomedical Engineering and Sciences (IECBES) (pp. 170-174). IEEE
Open this publication in new window or tab >>Counting Capillaries in Nailfold Capillaroscopy:State of the Art and a Proposed Method
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2016 (English)In: 2016 IEEE EMBS CONFERENCE ON BIOMEDICAL ENGINEERING AND SCIENCES (IECBES), IEEE, 2016, , p. 5p. 170-174Conference paper, Published paper (Refereed)
Abstract [en]

Capillaries play a crucial role in the microcirculatory system by exchanging metabolic substrates and waste products between blood and various tissues. The behavior of capillaries is affiliated with the number of capillaries per unit volume of tissue. Among the various noninvasive techniques available for analyzing skin microcirculation, nailfold capillaroscopyis considered to be a simple and easy-to-perform technique that allows a direct in-vivo visualization of the capillary network.Capillary density is one of the most important parameters in the studies involving capillaroscopy images. Capillary density in most of studies is defined as the number of capillaries in a one-millimeter span of the distal row in each finger or toe. This definition is silent about counting or excluding the number of the capillary with different shapes. However, there is no single standard for counting the number of capillaries in a span of one millimeter. In this paper, a novel method is proposed for determining the nailfold capillary density. This method is a modified combination of two existing techniques: the direct observation and the 90◦ method.Compared to the two existing approaches, the proposed method is more straightforward and easy to use for cases in which the capillaries have different shapes and sizes. Through different examples, we have shown how this method can be used to select the apex point of the capillary and subsequently count the number of capillaries with several papillae.

Place, publisher, year, edition, pages
IEEE, 2016. p. 5
National Category
Medical and Health Sciences
Research subject
Medical Technology
Identifiers
urn:nbn:se:kth:diva-224836 (URN)10.1109/IECBES.2016.7843437 (DOI)000400605700035 ()2-s2.0-85015704316 (Scopus ID)
Conference
Conference on Biomedical Engineering and Sciences (IECBES)
Note

QC 20180327

Available from: 2018-03-26 Created: 2018-03-26 Last updated: 2018-11-20Bibliographically approved
Akay, A., Dragomir, A. & Erlandsson, B.-E. (2015). A Novel Data-Mining Approach Leveraging Social Media to Monitor Consumer Opinion of Sitagliptin. IEEE journal of biomedical and health informatics, 19(1), 389-396
Open this publication in new window or tab >>A Novel Data-Mining Approach Leveraging Social Media to Monitor Consumer Opinion of Sitagliptin
2015 (English)In: IEEE journal of biomedical and health informatics, ISSN 2168-2194, E-ISSN 2168-2208, Vol. 19, no 1, p. 389-396Article in journal (Refereed) Published
Abstract [en]

A novel data mining method was developed to gauge the experience of the drug Sitagliptin (trade name Januvia) by patients with diabetes mellitus type 2. To this goal, we devised a two-step analysis framework. Initial exploratory analysis using self-organizing maps was performed to determine structures based on user opinions among the forum posts. The results were a compilation of user's clusters and their correlated (positive or negative) opinion of the drug. Subsequent modeling using network analysis methods was used to determine influential users among the forum members. These findings can open new avenues of research into rapid data collection, feedback, and analysis that can enable improved outcomes and solutions for public health and important feedback for the manufacturer.

Keywords
Data mining, network analysis, self-organizing map, social media
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering Information Systems
Identifiers
urn:nbn:se:kth:diva-159234 (URN)10.1109/JBHI.2013.2295834 (DOI)000347342300046 ()2-s2.0-84920903503 (Scopus ID)
Note

QC 20150128

Available from: 2015-01-26 Created: 2015-01-26 Last updated: 2018-01-11Bibliographically approved
Xu, X., Akay, A., Wei, H., Wang, S., Pingguan-Murphy, B., Erlandsson, B.-E., . . . Xu, F. (2015). Advances in Smartphone-Based Point-of-Care Diagnostics: This paper reviews the state-of-the-art advances in smartphone-based point-of-care diagnostic technologies and their applications in medicine and biology.. Proceedings of the IEEE, 103(2), 236-247
Open this publication in new window or tab >>Advances in Smartphone-Based Point-of-Care Diagnostics: This paper reviews the state-of-the-art advances in smartphone-based point-of-care diagnostic technologies and their applications in medicine and biology.
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2015 (English)In: Proceedings of the IEEE, ISSN 0018-9219, E-ISSN 1558-2256, Vol. 103, no 2, p. 236-247Article in journal (Refereed) Published
Abstract [en]

Point-of-care (POC) diagnostics is playing an increasingly important role in public health, environmental monitoring, and food safety analysis. Smartphones, alone or in conjunction with add-on devices, have shown great capability of data collection, analysis, display, and transmission, making them popular in POC diagnostics. In this article, the state-ofthe- art advances in smartphone-based POC diagnostic technologies and their applications in the past few years are outlined, ranging from in vivo tests that use smartphone’s built-in/external sensors to detect biological signals to in vitro tests that involves complicated biochemical reactions. Novel techniques are illustrated by a number of attractive examples, followed by a brief discussion of the smartphone’s role in telemedicine. The challenges and perspectives of smartphonebased POC diagnostics are also provided.

Keywords
Mobile medicine, point-of-care(POC) diagnostics, public health, smartphone
National Category
Engineering and Technology
Identifiers
urn:nbn:se:kth:diva-164306 (URN)10.1109/JPROC.2014.2378776 (DOI)000352156900009 ()2-s2.0-84926309099 (Scopus ID)
Note

QC 20150512

Available from: 2015-04-15 Created: 2015-04-15 Last updated: 2017-12-04Bibliographically approved
Akay, A., Dragomir, A. & Erlandsson, B.-E. (2015). Mining Social Media Big Data for Health. IEEE Pulse
Open this publication in new window or tab >>Mining Social Media Big Data for Health
2015 (English)In: IEEE PulseArticle, review/survey (Refereed) Published
Abstract [en]

Advances in information technology (IT) and big data are affecting nearly every facet of the public and private sectors. Social media platforms are one example of such advances: its nature allows users to connect, collaborate, and debate on any topic with comparative ease. The result is a hefty volume of user-generated content that, if properly mined and analyzed, could help the public and private health care sectors improve the quality of their products and services while reducing costs. The users of these platforms are the key to these improvements, as their valuable feedback will help improve health solutions.

National Category
Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Medical Technology
Identifiers
urn:nbn:se:kth:diva-180349 (URN)
Note

QC 20160112

Available from: 2016-01-12 Created: 2016-01-12 Last updated: 2017-03-13Bibliographically approved
Etehad Tavakol, M., Fatemi, A., Karbalaie, A., Emrani, Z. & Erlandsson, B.-E. (2015). Nailfold Capillaroscopy in Rheumatic Diseases: Which Parameters Should Be Evaluated?. BioMed Research International, 2015, Article ID 974530.
Open this publication in new window or tab >>Nailfold Capillaroscopy in Rheumatic Diseases: Which Parameters Should Be Evaluated?
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2015 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, Vol. 2015, article id 974530Article in journal (Refereed) [Artistic work] Published
Abstract [en]

Video nailfold capillaroscopy (NFC), considered as an extension of the widefield technique, allows a more accurate measuring andstoring of capillary data and a better defining, analyzing, and quantifying of capillary abnormalities. Capillaroscopic study is oftenperformed on the patients suspected of having microcirculation problems such as Raynaud’s phenomenon as the main indicationfor nailfold capillaroscopy. Capillaroscopic findings based on microcirculation studies can provide useful information in the fieldsof pathophysiology, differential diagnosis, and monitoring therapy. Nailfold capillaroscopy provides a vital assessment in clinicalpractices and research; for example, its reputation in the early diagnosis of systemic sclerosis is well established and it is also usedas a classification criterion in this regard. This review focuses on the manner of performing video nailfold capillaroscopy and on acommon approach for measuring capillary dimensions in fingers and toes.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2015
Keywords
Video nailfold capillaroscopy, Rheumatic diseases, Capillary density, Measurement of capillary dimensions
National Category
Biomedical Laboratory Science/Technology
Research subject
Applied Medical Technology
Identifiers
urn:nbn:se:kth:diva-172920 (URN)10.1155/2015/974530 (DOI)000361248100001 ()2-s2.0-84941730044 (Scopus ID)
Note

QC 20150903

Available from: 2015-09-01 Created: 2015-09-01 Last updated: 2018-11-20Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0002-1929-135X

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