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Svedmark, P., Berg, S., Noz, M. E., Maguire Jr., G. Q., Zeleznik, M. P., Weidenhielm, L., . . . Olivecrona, H. (2015). A New CT Method for Assessing 3D Movements in Lumbar Facet Joints and Vertebrae in Patients before and after TDR. BioMed Research International, 2015, 1-9, Article ID 260703.
Open this publication in new window or tab >>A New CT Method for Assessing 3D Movements in Lumbar Facet Joints and Vertebrae in Patients before and after TDR
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2015 (English)In: BioMed Research International, ISSN 2314-6133, Vol. 2015, p. 1-9, article id 260703Article in journal (Refereed) Published
Abstract [en]

This study describes a 3D-CT method for analyzing facet joint motion and vertebral rotation in the lumbar spine after TDR. Ten patients were examined before and then three years after surgery, each time with two CT scans: provoked flexion and provoked extension. After 3D registration, the facet joint 3D translation and segmental vertebral 3D rotation were analyzed at the operated level (L5-S1) and adjacent level (L4-L5). Pain was evaluated using VAS. The median (±SD) 3D movement in the operated level for the left facet joint was 3.2 mm (±1.9 mm) before and 3.5 mm (±1.7 mm) after surgery and for the right facet joint was 3.0 mm (±1.0 mm) before and 3.6 mm (±1.4 mm) after surgery. The median vertebral rotation in the sagittal plane at the operated level was 5.4° (±2.3°) before surgery and 6.8° (±1.7°) after surgery and in the adjacent level was 7.7° (±4.0°) before and 9.2° (±2.7°) after surgery. The median VAS was reduced from 6 (range 5–8) to 3 (range 2–8) in extension and from 4 (range 2–6) to 2 (range 1–3) in flexion.

National Category
Orthopaedics Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:kth:diva-176268 (URN)10.1155/2015/260703 (DOI)000364668500001 ()26587533 (PubMedID)2-s2.0-84947475183 (Scopus ID)
Note

QC 20151102

Available from: 2015-11-02 Created: 2015-11-02 Last updated: 2022-06-23Bibliographically approved
Lundblad, H., Maguire Jr., G. Q., Karlsson-Thur, C., Jonsson, C., Noz, M. E., Zeleznik, M. P., . . . Weidenhielm, L. (2015). Using PET/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences. BioMed Research International, 2015, 1-11, Article ID 574705.
Open this publication in new window or tab >>Using PET/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences
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2015 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, Vol. 2015, p. 1-11, article id 574705Article in journal (Refereed) Published
Abstract [en]

Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consentto undergo Na18F− PET/CT bone scans. We present a Patlak-like analysis utilizing an approximated blood time-activity curveeliminating the need for blood aliquots. Additionally, standardized uptake values (SUV) derived from dynamic acquisitions werecompared to this Patlak-like approach. Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal)bone, and muscle. The SUV𝑚(𝑡) (𝑚 = max, mean) and a series of slopes were computed as (SUV𝑚(𝑡𝑖) − SUV𝑚(𝑡𝑗))/(𝑡𝑖 − 𝑡𝑗), forpairs of time values 𝑡𝑖 and 𝑡𝑗. A Patlak-like analysis was performed for the same time values by computing ((VOI𝑝(𝑡𝑖)/VOI𝑒(𝑡𝑖)) −(VOI𝑝(𝑡𝑗)/VOI𝑒(𝑡𝑗)))/(𝑡𝑖−𝑡𝑗), where p = broken bone, other bone, andmuscle and e = expected activity in aVOI. Paired comparisonsbetween Patlak-like and SUV𝑚 slopes showed good agreement by both linear regression and correlation coefficient analysis(𝑟 = 84%, 𝑟𝑠 = 78%-SUVmax, 𝑟 = 92%, and 𝑟𝑠 = 91%-SUVmean), suggesting static scans could substitute for dynamic studies.Patlak-like slope differences of 0.1 min−1 or greater between examinations and SUVmax differences of ∼5 usually indicated goodremodeling progress, while negative Patlak-like slope differences of −0.06 min−1 usually indicated poor remodeling progress in thiscohort.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2015
National Category
Orthopaedics Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:kth:diva-173247 (URN)10.1155/2015/574705 (DOI)000361696200001 ()26436093 (PubMedID)2-s2.0-84942279320 (Scopus ID)
Note

QC 20150910

Available from: 2015-09-08 Created: 2015-09-08 Last updated: 2022-06-23Bibliographically approved
Lundblad, H., Maguire Jr., G. Q., Olivecrona, H., Jonsson, C., Jacobsson, H., Noz, M. E., . . . Sundin, A. (2014). Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame?. Scientific World Journal, 2014, 1-9
Open this publication in new window or tab >>Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame?
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2014 (English)In: Scientific World Journal, E-ISSN 1537-744X, Vol. 2014, p. 1-9Article in journal (Refereed) Published
Abstract [en]

Monitoring and quantifying bone remodeling are of interest, for example, in correction osteotomies, delayed fracture healing pseudarthrosis, bone lengthening, and other instances. Seven patients who had operations to attach an Ilizarov-derived Taylor Spatial Frame to the tibia gave informed consent. Each patient was examined by (NaF)-F-18 PET/CT twice, at approximately six weeks and three months after the operation. A validated software tool was used for the following processing steps. The first and second CT volumes were aligned in 3D and the respective PET volumes were aligned accordingly. In the first PET volume spherical volumes of interest (VOIs) were delineated for the crural fracture and normal bone and transferred to the second PET volume for SUVmax evaluation. This method potentially provides clinical insight into questions such as, when has the bone remodeling progressed well enough to safely remove the TSF? and when is intervention required, in a timelier manner than current methods? For example, in two patients who completed treatment, the SUVmax between the first and second PET/CT examination decreased by 42% and 13%, respectively. Further studies in a larger patient population are needed to verify these preliminary results by correlating regional (NaF)-F-18 PET measurements to clinical and radiological findings.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2014
Keywords
Na18F, PET/CT, Bone Remodeling, Taylor Spatial Frame
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:kth:diva-143408 (URN)10.1155/2014/249326 (DOI)000333602000001 ()24778581 (PubMedID)2-s2.0-84897484026 (Scopus ID)
Note

QC 20140505. QC 20160222

Available from: 2014-03-20 Created: 2014-03-20 Last updated: 2023-02-17Bibliographically approved
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-4280-1178

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