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2024 (English)In: Network Neuroscience, ISSN 2472-1751, Vol. 8, no 4, p. 1149-1172Article in journal (Refereed) Published
Abstract [en]
This in silico study predicts the impact that the single-cell neuronal morphological alterations will have on the striatal microcircuit connectivity. We find that the richness in the topological striatal motifs is significantly reduced in Parkinson's disease (PD), highlighting that just measuring the pairwise connectivity between neurons gives an incomplete description of network connectivity. Moreover, we predict how the resulting electrophysiological changes of striatal projection neuron excitability together with their reduced number of dendritic branches affect their response to the glutamatergic drive from the cortex and thalamus. We find that the effective glutamatergic drive is likely significantly increased in PD, in accordance with the hyperglutamatergic hypothesis.
Place, publisher, year, edition, pages
MIT Press, 2024
Keywords
Parkinson's disease, Striatum, Computational modeling, Topological data analysis, Directed cliques, Network higher order connectivity, Neuronal degeneration model
National Category
Neurosciences
Identifiers
urn:nbn:se:kth:diva-359481 (URN)10.1162/netn_a_00394 (DOI)001381061600014 ()39735495 (PubMedID)2-s2.0-105000619120 (Scopus ID)
Note
Not duplicate with DiVA 1813694
QC 20250206
2025-02-062025-02-062025-04-03Bibliographically approved