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Xu, Hao
Publications (2 of 2) Show all publications
Gan, Z. & Xu, H. (2017). Photoluminescence of Diphenylalanine Peptide Nano/Microstructures: From Mechanisms to Applications. Macromolecular rapid communications, 38(22), Article ID 1700370.
Open this publication in new window or tab >>Photoluminescence of Diphenylalanine Peptide Nano/Microstructures: From Mechanisms to Applications
2017 (English)In: Macromolecular rapid communications, ISSN 1022-1336, E-ISSN 1521-3927, Vol. 38, no 22, article id 1700370Article, review/survey (Refereed) Published
Abstract [en]

Diphenylalanine (Phe-Phe, FF) molecules, which can self-assemble into highly ordered nano/microstructures, have increasingly aroused intense interests due to their special optical properties. In this review, recent advances in photoluminescence (PL) of supramolecular architectures of FF-based peptide and the underlying mechanisms are highlighted. Mainly deep ultraviolet emission at around 285 nm and/or blue emission at approximate to 450 nm are observed in various FF peptide structures and its derivatives, which are primarily interpreted by quantum confinement effects, shallow radiative traps, and electron delocalization via hydrogen bonds in beta-sheet structures. Furthermore, current applications of such fluorescent peptide nano/microstructures are also reviewed here, e.g., probing the number of water molecules confined in FF, temperature sensing, and visualization of deep ultraviolet beam. Yet, the PL mechanism is still under fierce debate and the application based on fluorescence is constantly under exploration. Thus, this review is endeavored to boost future explorations on the PL of the bioinspired FF peptide nano/microstructures.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2017
amyloid proteins, deep ultraviolet, diphenylalanine, photoluminescence, self-assembly
National Category
Polymer Technologies
urn:nbn:se:kth:diva-220493 (URN)10.1002/marc.201700370 (DOI)000417215700002 ()2-s2.0-85029371987 (Scopus ID)
Science for Life Laboratory - a national resource center for high-throughput molecular bioscience

QC 20171221

Available from: 2017-12-21 Created: 2017-12-21 Last updated: 2017-12-21Bibliographically approved
Yin, H., Fontana, J. M., Solandt, J., Jussi, J. I., Xu, H., Brismar, H. & Fu, Y. (2017). Quantum dots modulate intracellular Ca2+ level in lung epithelial cells. International Journal of Nanomedicine, 12, 2781-2792
Open this publication in new window or tab >>Quantum dots modulate intracellular Ca2+ level in lung epithelial cells
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2017 (English)In: International Journal of Nanomedicine, ISSN 1176-9114, E-ISSN 1178-2013, Vol. 12, p. 2781-2792Article in journal (Refereed) Published
Abstract [en]

While adverse effects of nanoparticles on lung health have previously been proposed, few studies have addressed the direct effects of nanoparticle exposure on the airway epithelium. In this work, we examine the response of the pulmonary airway to nanoparticles by measuring intracellular Ca2+ concentration ([Ca2+](i)) in the Calu-3 epithelial layer stimulated by 3-mercaptopropionic-acid (3MPA) coated CdSe-CdS/ZnS core-multishell quantum dots (QDs). Simultaneous transient transepithelial electrical resistance (TEER) decrease and global [Ca2+](i) increase in Calu-3 epithelial layer, accompanied by cell displacements, contraction, and expansion, were observed under QD deposition. This suggests that a QD-induced global [Ca2+](i) increase in the Calu-3 epithelial layer caused the transient TEER decrease. The [Ca2+](i) increase was marked and rapid in the apical region, while [Ca2+](i) decreased in the basolateral region of the epithelial layer. TEER transient response and extracellular Ca2+ entry induced by QD deposition were completely inhibited in cells treated with stretched-activated (SA) inhibitor GdCl3 and store-operated calcium entry (SOCE) inhibitor BTP2 and in cells immersed in Ca2+-free medium. The voltage-gated calcium channel (VGCC) inhibitor nifedipine decreased, stabilized, and suppressed the TEER response, but did not affect the [Ca2+](i) increase, due to QD deposition. This demonstrates that the Ca2+ influx activated by QDs' mechanical stretch occurs through activation of both SA and SOCE channels. QD-induced [Ca2+](i) increase occurred in the Calu-3 epithelial layer after culturing for 15 days, while significant TEER drop only occurred after 23 days. This work provides a new perspective from which to study direct interactions between airway epithelium and nanoparticles and may help to reveal the pathologies of pulmonary disease.

Place, publisher, year, edition, pages
Calu-3 epithelial layer, quantum dot, intracellular Ca2+ concentration [Ca2+](i), transepithelial electrical resistance, cell movement
National Category
Nano Technology Pharmaceutical Sciences
urn:nbn:se:kth:diva-206308 (URN)10.2147/IJN.S130136 (DOI)000398663200001 ()2-s2.0-85017256402 (Scopus ID)

QC 20170505

Available from: 2017-05-05 Created: 2017-05-05 Last updated: 2018-01-13Bibliographically approved

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