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2020 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 12, no 4, p. 4276-4284Article in journal (Refereed) Published
Abstract [en]
Various squaraine dyes have been developed for biological imaging. Nevertheless, squaraine dyes with emission in the second window (NIR-II, 1000-1700 nm) have few reports largely due to the short of a simple and universal design strategy. In this contribution, molecular engineering strategy is explored to develop squaraine dyes with NIR-II emission. First, NIR-I squaraine dye SQ2 is constructed by the ethyl-grafted 1,8-naphtholactam as donor units and square acid as acceptor unit in a donor-acceptor-donor (D-A-D) structure. To red-shift the fluorescence emission into NIR-II window, malonitrile, as a forceful electron-withdrawing group, is introduced to strengthen square acid acceptor. As a result, the fluorescence spectrum of acceptor-engineered squaraine dye SQ1 exhibits a significant red- shift into NIR-II window. To translate NIR-II fluorophores SQ1 into effective theranostic agents, fibronectin-targeting SQ1 nanoprobe was constructed and showed excellent NIR-II imaging performance in angiography and tumor imaging, including lung metastatic foci in deep tissue. Furthermore, SQ1 nanoprobe can be used for photoacoustic imaging and photothermal ablation of tumors. This research demonstrates that the donor-acceptor engineering strategy is feasible and effective to develop NIR-II squaraine dyes.
Place, publisher, year, edition, pages
American Chemical Society (ACS), 2020
Keywords
breast cancer, lung metastasis, squaraine nanoprobe, NIR-II imaging, photoacoustic imaging
National Category
Chemical Sciences
Identifiers
urn:nbn:se:kth:diva-268809 (URN)10.1021/acsami.9b20147 (DOI)000510532000010 ()31896256 (PubMedID)2-s2.0-85078693597 (Scopus ID)
Note
QC 20200224
2020-02-242020-02-242022-06-26Bibliographically approved