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Hutchinson, D., Granskog, V., von Kieseritzky, J., Alfort, H., Stenlund, P., Zhang, Y., . . . Malkoch, M. (2021). Highly Customizable Bone Fracture Fixation through the Marriage of Composites and Screws. Advanced Functional Materials, 31(41), Article ID 2105187.
Open this publication in new window or tab >>Highly Customizable Bone Fracture Fixation through the Marriage of Composites and Screws
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2021 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 31, no 41, article id 2105187Article in journal (Refereed) Published
Abstract [en]

Open reduction internal fixation (ORIF) metal plates provide exceptional support for unstable bone fractures; however, they often result in debilitating soft‐tissue adhesions and their rigid shape cannot be easily customized by surgeons. In this work, a surgically feasible ORIF methodology, called AdhFix, is developed by combining screws with polymer/hydroxyapatite composites, which are applied and shaped in situ before being rapidly cured on demand via high‐energy visible‐light‐induced thiol–ene coupling chemistry. The method is developed on porcine metacarpals with transverse and multifragmented fractures, resulting in strong and stable fixations with a bending rigidity of 0.28 (0.03) N m 2 and a maximum load before break of 220 (15) N. Evaluations on human cadaver hands with proximal phalanx fractures show that AdhFix withstands the forces from finger flexing exercises, while short‐ and long‐term in vivo rat femur fracture models show that AdhFix successfully supports bone healing without degradation, adverse effects, or soft‐tissue adhesions. This procedure represents a radical new approach to fracture fixation, which grants surgeons unparalleled customizability and does not result in soft‐tissue adhesions.

Place, publisher, year, edition, pages
Wiley, 2021
Keywords
biomaterials, bone fixation, materials engineering, thiol-ene composites
National Category
Polymer Chemistry Orthopaedics Biomaterials Science
Identifiers
urn:nbn:se:kth:diva-297640 (URN)10.1002/adfm.202105187 (DOI)000663202700001 ()2-s2.0-85108182498 (Scopus ID)
Note

QC 20250331

Available from: 2021-06-21 Created: 2021-06-21 Last updated: 2025-03-31Bibliographically approved
Kieseritzky, J. V., Alfort, H., Granskog, V., Hutchinson, D., Stenlund, P., Bogestål, Y., . . . Malkoch, M. (2020). DendroPrime as an adhesion barrier on fracture fixation plates: an experimental study in rabbits. Journal of Hand Surgery, European Volume, 45(7), 742-747
Open this publication in new window or tab >>DendroPrime as an adhesion barrier on fracture fixation plates: an experimental study in rabbits
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2020 (English)In: Journal of Hand Surgery, European Volume, ISSN 1753-1934, E-ISSN 2043-6289, Vol. 45, no 7, p. 742-747Article in journal (Refereed) Published
Abstract [en]

We tested the anti-adhesional effect of a new thiol-ene-based coating in a rabbit model. In 12 New Zealand white rabbits, the periosteum and cortex of the proximal phalanx of the second toe of both hind paws was scratched. Stainless steel plates were fixated with screws. One plate was coated with DendroPrime and the other left bare. The non-operated second toes of both hind paws of an additional four rabbits served as controls. Seven weeks after surgery, the soft tissue adhesion to the plates was evaluated macroscopically, and joint mobility was measured biomechanically. Toe joint mobility was about 20% greater and statistically significant in specimens with coated plates compared with the bare plates. Soft tissue overgrowth and, in some cases, synovitis or adhesions between the plate and the tendon were observed on all bare plates but not on any of the coated plates. We conclude that the thiol-ene-based coating can improve joint mobility by about 20%. This material has a potential to reduce adhesion around plates in fracture surgery.

Place, publisher, year, edition, pages
SAGE Publications Ltd, 2020
Keywords
adhesion barrier, flexor tendon, Fracture, plate fixation, rabbit
National Category
Orthopaedics
Identifiers
urn:nbn:se:kth:diva-286460 (URN)10.1177/1753193420932477 (DOI)000542369100001 ()32558616 (PubMedID)2-s2.0-85086649097 (Scopus ID)
Note

QC 20201217

Available from: 2020-12-17 Created: 2020-12-17 Last updated: 2022-06-25Bibliographically approved
Granskog, V., Garcia-Gallego, S., von Kieseritzky, J., Pettersson, J., Stenlund, P., Zhang, Y., . . . Malkoch, M. (2018). High-performance and biocompatible thiol-ene based adhesive for bone fracture fixation. Paper presented at 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, AUG 19-23, 2018, Boston, MA. Abstracts of Papers of the American Chemical Society, 256
Open this publication in new window or tab >>High-performance and biocompatible thiol-ene based adhesive for bone fracture fixation
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2018 (English)In: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 256Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
AMER CHEMICAL SOC, 2018
National Category
Chemical Sciences
Identifiers
urn:nbn:se:kth:diva-238547 (URN)000447609105053 ()
Conference
256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, AUG 19-23, 2018, Boston, MA
Note

QC 20181105

Available from: 2018-11-05 Created: 2018-11-05 Last updated: 2024-03-15Bibliographically approved
Granskog, V., García-Gallego, S., von Kieseritzky, J., Rosendahl, J., Stenlund, P., Zhang, Y., . . . Malkoch, M. (2018). High-Performance Thiol–Ene Composites Unveil a New Era of Adhesives Suited for Bone Repair. Advanced Functional Materials, 28(26), Article ID 1800372.
Open this publication in new window or tab >>High-Performance Thiol–Ene Composites Unveil a New Era of Adhesives Suited for Bone Repair
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2018 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 28, no 26, article id 1800372Article in journal (Refereed) Published
Abstract [en]

The use of adhesives for fracture fixation can revolutionize the surgical procedures toward more personalized bone repairs. However, there are still no commercially available adhesive solutions mainly due to the lack of biocompatibility, poor adhesive strength, or inadequate fixation protocols. Here, a surgically realizable adhesive system capitalizing on visible light thiol–ene coupling chemistry is presented. The adhesives are carefully designed and formulated from a novel class of chemical constituents influenced by dental resin composites and self-etch primers. Validation of the adhesive strengthis conducted on wet bone substrates and accomplished via fiber-reinforced adhesive patch (FRAP) methodology. The results unravel, for the first time, on the promise of a thiol–ene adhesive with an unprecedented shear bondstrength of 9.0 MPa and that surpasses, by 55%, the commercially available acrylate dental adhesive system Clearfil SE Bond of 5.8 MPa. Preclinical validation of FRAPs on rat femur fracture models details good adhesion to the bone throughout the healing process, and are found biocompatible not giving rise to any inflammatory response. Remarkably, the FRAPs are found to withstand loads up to 70 N for 1000 cycles on porcine metacarpal fractures outperforming clinically used K-wires and match metal plates and screw implants.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018
National Category
Polymer Chemistry Biomaterials Science
Identifiers
urn:nbn:se:kth:diva-227151 (URN)10.1002/adfm.201800372 (DOI)000436104800012 ()2-s2.0-85048981911 (Scopus ID)
Funder
VINNOVA, 2014-03777Knut and Alice Wallenberg Foundation, 2012-0196Swedish Research Council, 2010-435EU, Horizon 2020, MSCA-IF-2014-655649
Note

QC 20180509

Available from: 2018-05-02 Created: 2018-05-02 Last updated: 2024-03-15Bibliographically approved
Arseneault, M., Granskog, V., Khosravi, S., Heckler, I., Antunez, P. M., Hult, D., . . . Malkoch, M. (2018). The Dawn of Thiol-Yne Triazine Triones Thermosets as a New Material Platform Suited for Hard Tissue Repair. Advanced Materials, 30(52), Article ID 1804966.
Open this publication in new window or tab >>The Dawn of Thiol-Yne Triazine Triones Thermosets as a New Material Platform Suited for Hard Tissue Repair
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2018 (English)In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 30, no 52, article id 1804966Article in journal (Refereed) Published
Abstract [en]

The identification of a unique set of advanced materials that can bear extraordinary loads for use in bone and tooth repair will inevitably unlock unlimited opportunities for clinical use. Herein, the design of high-performance thermosets is reported based on triazine-trione (TATO) monomers using light-initiated thiol-yne coupling (TYC) chemistry as a polymerization strategy. In comparison to traditional thiol-ene coupling (TEC) systems, TYC chemistry has yielded highly dense networks with unprecedented mechanical properties. The most promising system notes 4.6 GPa in flexural modulus and 160 MPa in flexural strength, an increase of 84% in modulus and 191% in strength when compared to the corresponding TATO system based on TEC chemistry. Remarkably, the mechanical properties exceed those of polylactide (PLA) and challenge poly(ether ether ketone) PEEK and today's methacrylate-based dental resin composites. All the materials display excellent biocompatibility, in vitro, and are successfully: i) molded into medical devices for fracture repair, and ii) used as bone adhesive for fracture fixation and as tooth fillers with the outstanding bond strength that outperform methacrylate systems used today in dental restoration application. Collectively, a new era of advanced TYC materials is unfolded that can fulfill the preconditions as bone fixating implants and for tooth restorations.

Place, publisher, year, edition, pages
Wiley, 2018
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:kth:diva-301038 (URN)10.1002/adma.201804966 (DOI)000454124800004 ()30387212 (PubMedID)2-s2.0-85055928738 (Scopus ID)
Note

QC 20210906

Available from: 2021-09-03 Created: 2021-09-03 Last updated: 2022-06-25Bibliographically approved
Heckler, I., Arseneault, M., Granskog, V., Antunez, P. M., Zhang, Y. & Malkoch, M. (2018). Triazine trione based adhesive as potential materials for bone fracture fixation. Paper presented at 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, AUG 19-23, 2018, Boston, MA. Abstracts of Papers of the American Chemical Society, 256
Open this publication in new window or tab >>Triazine trione based adhesive as potential materials for bone fracture fixation
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2018 (English)In: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 256Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
AMER CHEMICAL SOC, 2018
National Category
Chemical Sciences
Identifiers
urn:nbn:se:kth:diva-238549 (URN)000447609104809 ()
Conference
256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond, AUG 19-23, 2018, Boston, MA
Note

QC 20181105

Available from: 2018-11-05 Created: 2018-11-05 Last updated: 2024-03-15Bibliographically approved
Granskog, V., Garcia-Gallego, S., Zhang, Y. & Malkoch, M. (2017). Adhesion-enhancing primer for high-performance bone adhesive. Paper presented at 253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, Technologies, Systems, and Processes, APR 02-06, 2017, San Francisco, CA. Abstracts of Papers of the American Chemical Society, 253
Open this publication in new window or tab >>Adhesion-enhancing primer for high-performance bone adhesive
2017 (English)In: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 253Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
AMER CHEMICAL SOC, 2017
National Category
Organic Chemistry
Identifiers
urn:nbn:se:kth:diva-242590 (URN)000430569108178 ()
Conference
253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, Technologies, Systems, and Processes, APR 02-06, 2017, San Francisco, CA
Note

QC 20190226

Available from: 2019-02-26 Created: 2019-02-26 Last updated: 2022-12-08Bibliographically approved
Olofsson, K., Granskog, V., Cai, Y., Hult, A. & Malkoch, M. (2016). Activated dopamine derivatives as primers for adhesive-patch fixation of bone fractures. RSC Advances, 6(31), 26398-26405
Open this publication in new window or tab >>Activated dopamine derivatives as primers for adhesive-patch fixation of bone fractures
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2016 (English)In: RSC Advances, E-ISSN 2046-2069, Vol. 6, no 31, p. 26398-26405Article in journal (Refereed) Published
Abstract [en]

For the stabilization of complex bone fractures, tissue adhesives are an attractive alternative to conventional implants, often consisting of metal plates and screws whose fixation may impose additional trauma on the already fractured bone. This study reports on the synthesis and evaluation of activated dopamine derivatives as primers for fiber-reinforced-adhesive patches in bone-fracture stabilization strategies. The performance of synthesized dopamine derivatives are evaluated with regard to the adhesive shear strength of formed bone patches, as well as cell viability and surface properties. Dopamine-derived primers with methacrylamide, allyl, and thiol functional groups were found to significantly increase the adhesive shear strength of adhesive patches. Furthermore, deprotonation of the primer solution was determined to be essential in order to achieve good adhesion. In conclusion, the primer solutions that were found to give the best adhesion were the once where dopa-thiol was used in combination with either dopamethacrylamide or dopa-allyl, resulting in shear bond strengths of 0.29 MPa.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2016
National Category
Polymer Technologies
Identifiers
urn:nbn:se:kth:diva-185678 (URN)10.1039/c5ra23142f (DOI)000372812300090 ()2-s2.0-84961191443 (Scopus ID)
Note

QC 20160425

Available from: 2016-04-25 Created: 2016-04-25 Last updated: 2024-03-18Bibliographically approved
Granskog, V., Andren, O. C. J., Cai, Y., Gonzalez-Granillo, M., Fellander-Tsai, L., von Holst, H., . . . Malkoch, M. (2015). Linear Dendritic Block Copolymers as Promising Biomaterials for the Manufacturing of Soft Tissue Adhesive Patches Using Visible Light Initiated Thiol-Ene Coupling Chemistry. Advanced Functional Materials, 25(42), 6596-6605
Open this publication in new window or tab >>Linear Dendritic Block Copolymers as Promising Biomaterials for the Manufacturing of Soft Tissue Adhesive Patches Using Visible Light Initiated Thiol-Ene Coupling Chemistry
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2015 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 25, no 42, p. 6596-6605Article in journal (Refereed) Published
Abstract [en]

A library of dendritic-linear-dendritic (DLD) materials comprising linear poly(ethylene glycol) and hyperbranched dendritic blocks based on 2,2-bis(hydroxymethyl) propionic acid is successfully synthesized and post-functionalized with peripheral allyl groups. Reactive DLDs with pseudo-generations of 3 to 6 (G3-G6) are isolated in large scale allowing their thorough evaluation as important components for the development of biomedical adhesives. Due to their branched nature and inherent degradable ester-bonds, promising biomaterial resins are accomplished with suitable viscosity, eliminating the excessive use of co-solvents. By utilizing benign high-energy visible light initiated thiol-ene coupling chemistry, DLDs together with tris[2-(3-mercaptopropionyloxy) ethyl] isocyanurate and surgical mesh enable the fabrication of soft tissue adhesive patches (STAPs) within a total irradiation time of 30 s. The STAPs display the ability to create good adhesion to wet soft tissue and encouraging results in cytotoxicity tests. All crosslinked materials are also found to degrade after being stored in human blood plasma and phosphate buffered saline. The proposed benign methodology coupled with the promising features of the crosslinked materials is herein envisioned as a soft tissue adhesive with properties that do not exist in currently available tissue adhesives.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2015
National Category
Condensed Matter Physics Chemical Sciences Materials Engineering
Identifiers
urn:nbn:se:kth:diva-180135 (URN)10.1002/adfm.201503235 (DOI)000365532100004 ()2-s2.0-84948422356 (Scopus ID)
Note

QC 20160114

Available from: 2016-01-14 Created: 2016-01-07 Last updated: 2022-06-23Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-8595-0037

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