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Ren, Yansong
Publications (3 of 3) Show all publications
Ren, Y., Hu, L. & Ramström, O. (2019). Multienzymatic cascade synthesis of an enantiopure (2R,5R)-1,3-oxathiolane anti-HIV agent precursor. Molecular Catalysis, 468, 52-56
Open this publication in new window or tab >>Multienzymatic cascade synthesis of an enantiopure (2R,5R)-1,3-oxathiolane anti-HIV agent precursor
2019 (English)In: Molecular Catalysis, ISSN 2468-8231, Vol. 468, p. 52-56Article in journal (Refereed) Published
Abstract [en]

An enantiopure (2R,5R)-1,3-oxathiolane was obtained using a multienzymatic cascade protocol. By employing a combination of surfactant-treated subtilisin Carlsberg and Candida antarctica lipase B, the absolute configuration of the resulting 1,3-oxathiolane ring was efficiently controlled, resulting in an excellent enantiomeric excess (>99%). This enantiopure 1,3-oxathiolane derivative is a key precursor to anti-HIV agents, such as lamivudine, through subsequent N-glycosylation.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
1, 3-Oxathiolane, Candida antarctica lipase B, Enzyme, HIV, Subtilisin Carlsberg
National Category
Chemical Sciences
Identifiers
urn:nbn:se:kth:diva-246434 (URN)10.1016/j.mcat.2019.02.013 (DOI)000463293300007 ()2-s2.0-85061747406 (Scopus ID)
Note

QC 20190329

Available from: 2019-03-29 Created: 2019-03-29 Last updated: 2019-04-29Bibliographically approved
Zhang, P., Sheng, X., Chen, X., Fang, Z., Jiang, J., Wang, M., . . . Sun, L. (2019). Paired Electrocatalytic Oxygenation and Hydrogenation of Organic Substrates with Water as the Oxygen and Hydrogen Source. Angewandte Chemie International Edition, 58(27), 9155-9159
Open this publication in new window or tab >>Paired Electrocatalytic Oxygenation and Hydrogenation of Organic Substrates with Water as the Oxygen and Hydrogen Source
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2019 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 58, no 27, p. 9155-9159Article in journal (Refereed) Published
Abstract [en]

The use of water as an oxygen and hydrogen source for the paired oxygenation and hydrogenation of organic substrates to produce valuable chemicals is of utmost importance as a means of establishing green chemical syntheses. Inspired by the active Ni3+ intermediates involved in electro-catalytic water oxidation by nickel-based materials, we prepared NiBx as a catalyst and used water as the oxygen source for the oxygenation of various organic compounds. NiBx was further employed as both an anode and a cathode in a paired electrosynthesis cell for the respective oxygenation and hydrogenation of organic compounds, with water as both the oxygen and hydrogen source. Conversion efficiency and selectivity of >= 99% were observed during the oxygenation of 5-hydroxy-methylfurfural to 2,5-furandicarboxylic acid and the simultaneous hydrogenation of p-nitrophenol to p-aminophenol. This paired electrosynthesis cell has also been coupled to a solar cell as a stand-alone reactor in response to sunlight.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2019
Keywords
electrochemistry, green chemical synthesis, hydrogenation, oxygenation, water
National Category
Chemical Sciences
Identifiers
urn:nbn:se:kth:diva-255764 (URN)10.1002/anie.201903936 (DOI)000476691200033 ()31025774 (PubMedID)2-s2.0-85066906976 (Scopus ID)
Note

QC 20190816

Available from: 2019-08-16 Created: 2019-08-16 Last updated: 2019-08-16Bibliographically approved
Ren, Y., Svensson, P. H. & Ramström, O. (2018). A Multicontrolled Enamine Configurational Switch Undergoing Dynamic Constitutional Exchange. Angewandte Chemie International Edition, 57(21), 6256-6260
Open this publication in new window or tab >>A Multicontrolled Enamine Configurational Switch Undergoing Dynamic Constitutional Exchange
2018 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 57, no 21, p. 6256-6260Article in journal (Refereed) Published
Abstract [en]

A multiresponsive enamine-based molecular switch is presented, in which forward/backward configurational rotation around the C=C bond could be precisely controlled by the addition of an acid/base or metal ions. Fluorescence turn-on/off effects and large Stokes shifts were observed while regulating the switching process with Cu-II. The enamine functionality furthermore enabled double dynamic regimes, in which configurational switching could operate in conjunction with constitutional enamine exchange of the rotor part. This behavior was used to construct a prototypical dynamic covalent switch system through enamine exchange with primary amines. The dynamic exchange process could be readily turned on/off by regulating the switch status with pH.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH, 2018
Keywords
dynamic exchange, enamines, fluorescence, E/Z isomerization, molecular switches
National Category
Physical Chemistry
Identifiers
urn:nbn:se:kth:diva-230434 (URN)10.1002/anie.201802994 (DOI)000432710100049 ()29601656 (PubMedID)2-s2.0-85046299449 (Scopus ID)
Note

QC 20180615

Available from: 2018-06-15 Created: 2018-06-15 Last updated: 2018-10-30Bibliographically approved
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