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Merényi, Gabor
Publications (2 of 2) Show all publications
Augusto, O., Goldstein, S., Hurst, J. K., Lind, J., Lymar, S. V., Merényi, G. & Radi, R. (2019). Carbon dioxide-catalyzed peroxynitrite reactivity - The resilience of the radical mechanism after two decades of research. Free Radical Biology & Medicine, 135, 210-215
Open this publication in new window or tab >>Carbon dioxide-catalyzed peroxynitrite reactivity - The resilience of the radical mechanism after two decades of research
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2019 (English)In: Free Radical Biology & Medicine, ISSN 0891-5849, Vol. 135, p. 210-215Article, review/survey (Refereed) Published
Abstract [en]

Peroxynitrite, ONOO-, formed in tissues that are simultaneously generating NO center dot and O-2(center dot-), is widely regarded as a major contributor to oxidative stress. Many of the reactions involved are catalyzed by CO2 via formation of an unstable adduct, ONOOC(O)O-, that undergoes O-O bond homolysis to produce NO2 center dot and CO3 center dot- radicals, whose yields are equal at about 0.33 with respect to the ONOO- reactant. Since its inception two decades ago, this radical-based mechanism has been frequently but unsuccessfully challenged. The most recent among these [Serrano-Luginbuehl et al. Chem. Res. Toxicol. 31: 721-730; 2018] claims that ONOOC(O)O- is stable, predicts a yield of NO2 center dot/CO3 center dot- of less than 0.01 under physiological conditions and, contrary to widely accepted viewpoints, suggests that radical generation is inconsequential to peroxynitrite-induced oxidative damage. Here we review the experimental and theoretical evidence that support the radical model and show this recently proposed alternative mechanism to be incorrect.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC, 2019
National Category
Physical Chemistry
Identifiers
urn:nbn:se:kth:diva-252395 (URN)10.1016/j.freeradbiomed.2019.02.026 (DOI)000465927200020 ()30818056 (PubMedID)2-s2.0-85063040223 (Scopus ID)
Note

QC 20190613

Available from: 2019-06-13 Created: 2019-06-13 Last updated: 2019-06-13Bibliographically approved
Armstronga, D. A., Huie, R. E., Lymar, S., Koppenol, W. H., Merényi, G., Neta, P., . . . Wardman, P. (2013). Standard electrode potentials involving radicals in aqueous solution: Inorganic radicals. BioInorganic Reaction Mechanisms, 9(1-4), 59-61
Open this publication in new window or tab >>Standard electrode potentials involving radicals in aqueous solution: Inorganic radicals
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2013 (English)In: BioInorganic Reaction Mechanisms, ISSN 2191-2491, Vol. 9, no 1-4, p. 59-61Article in journal (Refereed) Published
Abstract [en]

Inorganic radicals, such as superoxide and hydroxyl, play an important role in biology. Their tendency to oxidize or to reduce other compounds has been studied by pulse radiolysis; electrode potentials can be derived when equilibrium is established with a well-known reference compound. An IUPAC Task Group has evaluated the literature and produced the recommended standard electrode potentials for such couples as (O2/O2 ·-), (HO·, H+/H2O), (O3/O3 ·-), (Cl2/Cl2 ·-), (Br2 ·-/2Br-), (NO2 ·/NO2 -), and (CO3 ·-/CO3 2-). 

Place, publisher, year, edition, pages
Walter de Gruyter GmbH, 2013
Keywords
Electrode potential, Inorganic radical
National Category
Inorganic Chemistry
Identifiers
urn:nbn:se:kth:diva-236926 (URN)10.1515/irm-2013-0005 (DOI)2-s2.0-85050971912 (Scopus ID)
Note

QC 20181210

Available from: 2018-12-10 Created: 2018-12-10 Last updated: 2018-12-10Bibliographically approved
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