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Zhang, Yuning
Publications (6 of 6) Show all publications
Andrén, O. C. J., Ingverud, T., Hult, D., Håkansson, J., Bogestål, Y., Caous, J. S., . . . Malkoch, M. (2019). Antibiotic-Free Cationic Dendritic Hydrogels as Surgical-Site-Infection-Inhibiting Coatings. Advanced Healthcare Materials, 8(5)
Open this publication in new window or tab >>Antibiotic-Free Cationic Dendritic Hydrogels as Surgical-Site-Infection-Inhibiting Coatings
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2019 (English)In: Advanced Healthcare Materials, ISSN 2192-2640, E-ISSN 2192-2659, Vol. 8, no 5Article in journal (Refereed) Published
Abstract [en]

Abstract A non-toxic hydrolytically fast-degradable antibacterial hydrogel is herein presented to preemptively treat surgical site infections during the first crucial 24 h period without relying on conventional antibiotics. The approach capitalizes on a two-component system that form antibacterial hydrogels within 1 min and consist of i) an amine functional linear-dendritic hybrid based on linear poly(ethylene glycol) and dendritic 2,2-bis(hydroxymethyl)propionic acid, and ii) a di-N-hydroxysuccinimide functional poly(ethylene glycol) cross-linker. Broad spectrum antibacterial effect is achieved by multivalent representation of catatonically charged ?-alanine on the dendritic periphery of the linear dendritic component. The hydrogels can be applied readily in an in vivo setting using a two-component syringe delivery system and the mechanical properties can accurately be tuned in the range equivalent to fat tissue and cartilage (G? = 0.5?8 kPa). The antibacterial effect is demonstrated both in vitro toward a range of relevant bacterial strains and in an in vivo mouse model of surgical site infection.

Place, publisher, year, edition, pages
John Wiley & Sons, Ltd, 2019
Keywords
antibacterial, dendrimer, hydrogels, surgical-site infection
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:kth:diva-249169 (URN)10.1002/adhm.201801619 (DOI)000461575200014 ()2-s2.0-85061270456 (Scopus ID)
Note

QC 20190412

Available from: 2019-04-11 Created: 2019-04-11 Last updated: 2019-04-12Bibliographically approved
Zhang, Y., Andrén, O. C. J., Nordström, R., Fan, Y., Malmsten, M., Mongkhontreerat, S. & Malkoch, M. (2019). Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics. Advanced Functional Materials, 29(18), Article ID 1806693.
Open this publication in new window or tab >>Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics
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2019 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 29, no 18, article id 1806693Article in journal (Refereed) Published
Abstract [en]

A novel platform of dendritic nanogels is herein presented, capitalizing on the self-assembly of allyl-functional polyesters based on dendritic-linear-dendritic amphiphiles followed by simple cross-linking with complementary monomeric thiols via UV initiated off-stoichiometric thiol-ene chemistry. The facile approach enabled multigram creation of allyl reactive nanogel precursors, in the size range of 190–295 nm, being readily available for further modifications to display a number of core functionalities while maintaining the size distribution and characteristics of the master batch. The nanogels are evaluated as carriers of a spread of chemotherapeutics by customizing the core to accommodate each individual cargo. The resulting nanogels are biocompatible, displaying diffusion controlled release of cargo, maintained therapeutic efficacy, and decreased cargo toxic side effects. Finally, the nanogels are found to successfully deliver pharmaceuticals into a 3D pancreatic spheroids tumor model. © 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Place, publisher, year, edition, pages
Wiley-VCH Verlag, 2019
Keywords
cancer treatment, dendritic nanogel, drug delivery, nanomedicine, 3D modeling, Biocompatibility, Controlled drug delivery, Medical nanotechnology, Oncology, Self assembly, Targeted drug delivery, Core functionality, Diffusion controlled, Linear dendritic, Master batch, Nanogels, Therapeutic efficacy, Thiol-ene chemistries, Toxic side effects, Nanostructured materials
National Category
Materials Chemistry
Identifiers
urn:nbn:se:kth:diva-252526 (URN)10.1002/adfm.201806693 (DOI)000471330500004 ()2-s2.0-85062732882 (Scopus ID)
Note

QC 20190605

Available from: 2019-06-05 Created: 2019-06-05 Last updated: 2019-10-28Bibliographically approved
Stenström, P., Manzanares, D., Zhang, Y., Ceña, V. & Malkoch, M. (2018). Evaluation of amino-functional polyester dendrimers based on Bis-MPA as nonviral vectors for siRNA delivery. Molecules, 23(8), Article ID 2028.
Open this publication in new window or tab >>Evaluation of amino-functional polyester dendrimers based on Bis-MPA as nonviral vectors for siRNA delivery
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2018 (English)In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 23, no 8, article id 2028Article in journal (Refereed) Published
Abstract [en]

Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. The study encompassed dendrimers of generation one to four (G1-G4), modified to bear 6-48 amino end-groups, where the G2-G4 proved to be capable of siRNA complexation and protection against RNase-mediated degradation. The dendrimers were nontoxic to astrocytes, glioma (C6), and glioblastoma (U87), while G3 and G4 exhibited concentration dependent toxicity towards primary neurons. The G2 showed no toxicity to primary neurons at any of the tested concentrations. Fluorescence microscopy experiments suggested that the dendrimers are highly efficient at endo-lysosomal escape since fluorescently labeled dendrimers were localized specifically in mitochondria, and diffuse cytosolic distribution of fluorescent siRNA complexed by dendrimers was observed. This is a desired feature for intracellular drug delivery, since the endocytic pathway otherwise transfers the drugs into lysosomes where they can be degraded without reaching their intended target. siRNA-transfection was successful in C6 and U87 cell lines using the G3 and G4 dendrimers followed by a decrease of approximately 20% of target protein p42-MAPK expression.

Place, publisher, year, edition, pages
MDPI AG, 2018
Keywords
Bis-MPA, Dendrimer, Monodisperse, Polycation, RNAi, SiRNA
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:kth:diva-238030 (URN)10.3390/molecules23082028 (DOI)000445295500193 ()2-s2.0-85053600476 (Scopus ID)
Note

Export Date: 30 October 2018; Article; CODEN: MOLEF; Correspondence Address: Malkoch, M.; Fiber and Polymer Technology, KTH Royal Institute of TechnologySweden; email: malkoch@kth.se

QC 20190115

Available from: 2019-01-15 Created: 2019-01-15 Last updated: 2019-01-15Bibliographically approved
Arseneault, M., Granskog, V., Khosravi, S., Heckler, I., Antunez, P. M., Hult, D., . . . Malkoch, M. (2018). The Dawn of Thiol-Yne Triazine Triones Thermosets as a New Material Platform Suited for Hard Tissue Repair. Advanced Materials, 30(52), Article ID 1804966.
Open this publication in new window or tab >>The Dawn of Thiol-Yne Triazine Triones Thermosets as a New Material Platform Suited for Hard Tissue Repair
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2018 (English)In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 30, no 52, article id 1804966Article in journal (Refereed) Published
Abstract [en]

The identification of a unique set of advanced materials that can bear extraordinary loads for use in bone and tooth repair will inevitably unlock unlimited opportunities for clinical use. Herein, the design of high-performance thermosets is reported based on triazine-trione (TATO) monomers using light-initiated thiol-yne coupling (TYC) chemistry as a polymerization strategy. In comparison to traditional thiol-ene coupling (TEC) systems, TYC chemistry has yielded highly dense networks with unprecedented mechanical properties. The most promising system notes 4.6 GPa in flexural modulus and 160 MPa in flexural strength, an increase of 84% in modulus and 191% in strength when compared to the corresponding TATO system based on TEC chemistry. Remarkably, the mechanical properties exceed those of polylactide (PLA) and challenge poly(ether ether ketone) PEEK and today's methacrylate-based dental resin composites. All the materials display excellent biocompatibility, in vitro, and are successfully: i) molded into medical devices for fracture repair, and ii) used as bone adhesive for fracture fixation and as tooth fillers with the outstanding bond strength that outperform methacrylate systems used today in dental restoration application. Collectively, a new era of advanced TYC materials is unfolded that can fulfill the preconditions as bone fixating implants and for tooth restorations.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2018
Keywords
biomedical applications, dental fillers, implants, polymeric materials, thiol-yne photochemistry
National Category
Other Engineering and Technologies
Identifiers
urn:nbn:se:kth:diva-240993 (URN)10.1002/adma.201804966 (DOI)000454124800004 ()30387212 (PubMedID)2-s2.0-85055928738 (Scopus ID)
Note

QC 20190110

Available from: 2019-01-10 Created: 2019-01-10 Last updated: 2019-04-09Bibliographically approved
Granskog, V., Garcia-Gallego, S., Zhang, Y. & Malkoch, M. (2017). Adhesion-enhancing primer for high-performance bone adhesive. Paper presented at 253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, Technologies, Systems, and Processes, APR 02-06, 2017, San Francisco, CA. Abstracts of Papers of the American Chemical Society, 253
Open this publication in new window or tab >>Adhesion-enhancing primer for high-performance bone adhesive
2017 (English)In: Abstracts of Papers of the American Chemical Society, ISSN 0065-7727, Vol. 253Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
AMER CHEMICAL SOC, 2017
National Category
Organic Chemistry
Identifiers
urn:nbn:se:kth:diva-242590 (URN)000430569108178 ()
Conference
253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, Technologies, Systems, and Processes, APR 02-06, 2017, San Francisco, CA
Note

QC 20190226

Available from: 2019-02-26 Created: 2019-02-26 Last updated: 2019-08-20Bibliographically approved
Engström, J., Asem, H., Brismar, H., Zhang, Y., Malkoch, M. & Malmström, E.In situ encapsulation of Nile red or Doxorubicinduring RAFT‐mediated emulsion polymerizationvia PISA.
Open this publication in new window or tab >>In situ encapsulation of Nile red or Doxorubicinduring RAFT‐mediated emulsion polymerizationvia PISA
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(English)Manuscript (preprint) (Other academic)
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:kth:diva-241454 (URN)
Note

QC 20190123

Available from: 2019-01-22 Created: 2019-01-22 Last updated: 2019-01-23Bibliographically approved
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