Change search
Link to record
Permanent link

Direct link
BETA
Publications (5 of 5) Show all publications
Wang, X., Herting, G., Wei, Z., Odnevall Wallinder, I. & Hedberg, Y. (2019). Bioaccessibility of nickel and cobalt in powders and massive forms of stainless steel, nickel- or cobalt-based alloys, and nickel and cobalt metals in artificial sweat. Regulatory toxicology and pharmacology, 106, 15-26
Open this publication in new window or tab >>Bioaccessibility of nickel and cobalt in powders and massive forms of stainless steel, nickel- or cobalt-based alloys, and nickel and cobalt metals in artificial sweat
Show others...
2019 (English)In: Regulatory toxicology and pharmacology, ISSN 0273-2300, E-ISSN 1096-0295, Vol. 106, p. 15-26Article in journal (Refereed) Published
Abstract [en]

Nickel (Ni)and cobalt (Co)are the most common metal allergens upon skin contact at occupational settings and during consumer handling of metals and alloys. A standardized test (EN, 1811)exists to assess Ni release from articles of metals and alloys in massive forms intended for direct and prolonged skin contact, but no corresponding test exists for other materials such as powders or massive forms of alloys placed on the market or to determine the release of Co, for which only limited data is available. Differences in Ni and Co release from massive forms of a range of common stainless steels and some high-alloyed grades compared to Ni and Co metals were therefore assessed in artificial sweat for 1 week at 30 °C according to EN 1811. A comparable modified test procedure was elaborated and used for powders and some selected massive alloys. All alloys investigated released significantly less amount of Ni (100–5000-fold)and Co (200–400,000-fold)compared with Ni and Co metal, respectively. Almost all alloys showed a lower bioaccessible concentration (0.007–6.8 wt% Ni and 0.00003–0.6 wt% Co)when compared to corresponding bulk alloy contents (0.1–53 wt% Ni, 0.02–65 wt% Co). Observed differences are, among other factors, related to differences in bulk composition and to surface oxide characteristics. For the powders, less Ni and Co were released per surface area, but more per mass, compared to the corresponding massive forms. © 2019 The Authors

Place, publisher, year, edition, pages
Academic Press Inc., 2019
Keywords
Artificial sweat, Classification, Corrosion, EN 1811, Metal release, Particles, Regulation, Skin sensitizer, alloy, cobalt, dermatological agent, nickel, oxide, stainless steel, unclassified drug, Article, calibration, chemical composition, concentration (parameter), particle size, pH, powder, priority journal, surface area, surface property
National Category
Materials Chemistry
Identifiers
urn:nbn:se:kth:diva-252512 (URN)10.1016/j.yrtph.2019.04.017 (DOI)2-s2.0-85064756776 (Scopus ID)
Note

QC 20190710

Available from: 2019-07-10 Created: 2019-07-10 Last updated: 2019-07-10Bibliographically approved
Hedberg, Y., Wei, Z. & Chevez, F. M. (2019). Chromium(III), chromium(VI) and cobalt release from leathers produced in Nicaragua. Contact Dermatitis, 80(3), 149-155
Open this publication in new window or tab >>Chromium(III), chromium(VI) and cobalt release from leathers produced in Nicaragua
2019 (English)In: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 80, no 3, p. 149-155Article in journal (Refereed) Published
Abstract [en]

Background: Leather exposure has been associated with chromium (Cr) and cobalt (Co) contact dermatitis. Cr(VI) in leather is now restricted to < 3 mg/kg in the EU. Cr(III) is not restricted. Objectives: To analyse 29 differently coloured Cr-tanned leather samples from two Nicaraguan tanneries, and to compare their release of Cr, Cr(VI) and Co with that of leathers produced in Europe. Methods: Cr, Cr(VI) and Co were extracted in phosphate buffer for 3 hours at 25 degrees C according to EN ISO 17075. Atomic absorption spectroscopy and spectrophotometry were used for detection of the metals in phosphate buffer. Results: There was no difference in total Cr or Cr(VI) release between European and Nicaraguan leathers. There was no association between Cr(VI) and total Cr release. Co was released primarily from leathers of one tannery. Cr(III) was released in significantly higher amounts than Cr(VI). Conclusions: Future investigations and regulations should focus on Cr(III) and Co as well as on Cr(VI).

Place, publisher, year, edition, pages
WILEY, 2019
Keywords
allergic contact dermatitis, chromium, chromium(VI), cobalt, exposure analysis, leather
National Category
Other Chemistry Topics
Identifiers
urn:nbn:se:kth:diva-244500 (URN)10.1111/cod.13165 (DOI)000457748900002 ()30485451 (PubMedID)2-s2.0-85057855384 (Scopus ID)
Note

QC 20190328

Available from: 2019-03-28 Created: 2019-03-28 Last updated: 2019-04-04Bibliographically approved
McCarrick, S., Wei, Z., Moelijker, N., Derr, R., Persson, K.-A., Hendriks, G., . . . Karlsson, H. L. (2019). High variability in toxicity of welding fume nanoparticles from stainless steel in lung cells and reporter cell lines: the role of particle reactivity and solubility. Nanotoxicology (O, 2017, ISO 17075-1, Leather - Chemical Determination of Chromium(VI) Content in Leather - Part 1: Colorimetric Method, tonini JM, 1999, JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A, V58, P343 Neilly JD, 2004, TOXICOLOGY AND APPLIED PHARMACOLOGY, V196, P95 ube Fabian, 2013, ANNALS OF OCCUPATIONAL HYGIENE, V57, P6 tonini JM, 2003, CRITICAL REVIEWS IN TOXICOLOGY, V33, P61 bano A. M., 2012, CURRENT DRUG METABOLISM, V13, P284 aveen P, 2005, JOURNAL OF MATERIALS PROCESSING TECHNOLOGY8th International Conference on Advances in Materials and Processing Technologies/13th International Conference on Achievements in Mechanical and Materials Engineering, MAY 16-19, 2005, Gliwice Wisla, POLAND, V164, P1113 Bucchianico Sebastiano, 2017, MUTAGENESIS, V32, P127)
Open this publication in new window or tab >>High variability in toxicity of welding fume nanoparticles from stainless steel in lung cells and reporter cell lines: the role of particle reactivity and solubility
Show others...
2019 (English)In: Nanotoxicology, ISSN 1743-5390, E-ISSN 1743-5404, no O, 2017, ISO 17075-1, Leather - Chemical Determination of Chromium(VI) Content in Leather - Part 1: Colorimetric Method, tonini JM, 1999, JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A, V58, P343 Neilly JD, 2004, TOXICOLOGY AND APPLIED PHARMACOLOGY, V196, P95 ube Fabian, 2013, ANNALS OF OCCUPATIONAL HYGIENE, V57, P6 tonini JM, 2003, CRITICAL REVIEWS IN TOXICOLOGY, V33, P61 bano A. M., 2012, CURRENT DRUG METABOLISM, V13, P284 aveen P, 2005, JOURNAL OF MATERIALS PROCESSING TECHNOLOGY8th International Conference on Advances in Materials and Processing Technologies/13th International Conference on Achievements in Mechanical and Materials Engineering, MAY 16-19, 2005, Gliwice Wisla, POLAND, V164, P1113 Bucchianico Sebastiano, 2017, MUTAGENESIS, V32, P127Article in journal (Refereed) Published
Abstract [en]

Millions of people in the world perform welding as their primary occupation resulting in exposure to metal-containing nanoparticles in the fumes generated. Even though health effects including airway diseases are well-known, there is currently a lack of studies investigating how different welding set-ups and conditions affect the toxicity of generated nanoparticles of the welding fume. The aim of this study was to investigate the toxicity of nine types of welding fume particles generated via active gas shielded metal arc welding (GMAW) of chromium-containing stainless steel under different conditions and, furthermore, to correlate the toxicity to the particle characteristics. Toxicological endpoints investigated were generation of reactive oxygen species (ROS), cytotoxicity, genotoxicity and activation of ToxTracker reporter cell lines. The results clearly underline that the choice of filler material has a large influence on the toxic potential. Fume particles generated by welding with the tested flux-cored wire (FCW) were found to be more cytotoxic compared to particles generated by welding with solid wire or metal-cored wire (MCW). FCW fume particles were also the most potent in causing ROS and DNA damage and they furthermore activated reporters related to DNA double- strand breaks and p53 signaling. Interestingly, the FCW fume particles were the most soluble in PBS, releasing more chromium in the hexavalent form and manganese compared to the other fumes. These results emphasize the importance of solubility of different metal constituents of the fume particles, rather than the total metal content, for their acute toxic potential.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD, 2019
Keywords
Welding, genotoxicity, ToxTracker, chromium(VI), manganese, metal release
National Category
Nano Technology
Identifiers
urn:nbn:se:kth:diva-257811 (URN)10.1080/17435390.2019.1650972 (DOI)000481646900001 ()31418618 (PubMedID)2-s2.0-85070998815 (Scopus ID)
Note

QC 20190906

Available from: 2019-09-06 Created: 2019-09-06 Last updated: 2019-09-06Bibliographically approved
Atapour, M., Wei, Z., Chaudhary, H., Lendel, C., Odnevall Wallinder, I. & Hedberg, Y. (2019). Metal release from stainless steel 316L in whey protein - And simulated milk solutions under static and stirring conditions. Food Control, 101, 163-172
Open this publication in new window or tab >>Metal release from stainless steel 316L in whey protein - And simulated milk solutions under static and stirring conditions
Show others...
2019 (English)In: Food Control, ISSN 0956-7135, E-ISSN 1873-7129, Vol. 101, p. 163-172Article in journal (Refereed) Published
Abstract [en]

Stainless steel is an important transport and processing contact material for bovine milk and dairy products. Release (migration) of metals, ions, complexes or wear debris/particles, and metal-induced protein aggregation in such environments are hence important to consider both from a corrosion and food safety perspective. This study aims on investigating the release of iron (Fe), chromium (Cr), and nickel (Ni) from AISI 316L stainless steel in contact with whey protein solutions relevant for protein drinks, and on how the whey proteins are influenced by stirring with a magnetic stir bar and metal release. Mechanistic insight is gained by parallel investigations of metal release from two reference non-protein containing solutions, a metal-complexing (citrate-containing) simulated milk solution (SMS) and a low complexing phosphate buffered saline solution (PBS). All immersion exposures were conducted at pH 6.8 for 0.5, 4, 24 and 48 hat room temperature at static and stirring conditions. All solutions and samples were investigated using different chemical, spectroscopic, microscopic, and electrochemical methods. Significantly higher amounts of Fe, Cr, and Ni were released into the whey protein solution (80 g/L) as compared to SMS and PBS. Strong enrichment of Cr in the surface oxide and reduction of the surface oxide thickness were associated with a higher amount of Ni release in the metal-complexing solutions (SMS and whey protein) compared with PBS. Stirring conditions resulted in higher amounts of metal release, enrichment of Cr in the surface oxide, and clear signs of wear of the 316L surface in all solutions compared to static conditions. The wear mechanism in the whey protein solution was different as compared to corresponding processes in SMS and PBS, involving an etching-like process and larger-sized wear debris. Electrochemical measurements at static conditions confirmed observed differences between the solutions, with the lowest corrosion resistance observed for coupons exposed in the whey protein solution, followed by SMS and PBS. Released metals in solution from the 316L coupons in contact with the whey protein solution resulted in enhanced rates of protein aggregation and precipitation of protein aggregates from solution. Further studies should be made to investigate other relevant test conditions and assess toxicological risks.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD, 2019
Keywords
Protein, Whey, Stainless steel, Metal release, Food, Milk, Atomic absorption spectroscopy, X-ray photoelectron spectroscopy, Photon cross correlation spectroscopy, UV- visible spectroscopy, Scanning electron microscopy, Polarization resistance, Corrosion
National Category
Corrosion Engineering
Identifiers
urn:nbn:se:kth:diva-251269 (URN)10.1016/j.foodcont.2019.02.031 (DOI)000465049000023 ()2-s2.0-85063112841 (Scopus ID)
Note

QC 20190513

Available from: 2019-05-13 Created: 2019-05-13 Last updated: 2019-05-29Bibliographically approved
Hedberg, Y., Dobryden, I., Chaudhary, H., Wei, Z., Claesson, P. M. & Lendel, C. (2019). Synergistic effects of metal-induced aggregation of human serum albumin. Colloids and Surfaces B: Biointerfaces, 173, 751-758
Open this publication in new window or tab >>Synergistic effects of metal-induced aggregation of human serum albumin
Show others...
2019 (English)In: Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, E-ISSN 1873-4367, Vol. 173, p. 751-758Article in journal (Refereed) Published
Abstract [en]

Exposure to cobalt (Co), chromium (Cr), and nickel (Ni) occurs often via skin contact and from different dental and orthopedic implants. The metal ions bind to proteins, which may induce structural changes and aggregation, with different medical consequences. We investigated human serum albumin (HSA) aggregation in the presence of Co-II, Cr-III, and/or Ni-II ions and/or their nanoparticle precipitates by using scattering, spectroscopic, and imaging techniques, at simulated physiological conditions (phosphate buffered saline - PBS, pH 7.3) using metal salts that did not affect the pH, and at HSA:metal molar ratios of up to 1:8. Co ions formed some solid nano particles in PBS at the investigated conditions, as determined by nanoparticle tracking analysis, but the Cr-III anions and Ni-II ions remained fully soluble. It was found that all metal ions induced HSA aggregation, and this effect was significantly enhanced when a mixture of all three metal ions was present instead of any single type of ion. Thus, the metal ions induce aggregation synergistically. HSA aggregates formed linear structures on a mica surface in the presence of Cr-III ions. A clear tendency of aggregation and linearly aligned aggregates was seen in the presence of all three metal ions. Spectroscopic investigations indicated that the majority of the HSA molecules maintained their alpha helical secondary structure and conformation. This study highlights the importance of synergistic effects of metal ions and/or their precipitates on protein aggregation, which are highly relevant for implant materials and common exposures to metals.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV, 2019
Keywords
Cobalt, Chromium, Nickel, Binding, Albumin, Aggregation
National Category
Physical Chemistry
Identifiers
urn:nbn:se:kth:diva-241193 (URN)10.1016/j.colsurfb.2018.10.061 (DOI)000454377300089 ()30384272 (PubMedID)2-s2.0-85055579350 (Scopus ID)
Note

QC 20190121

Available from: 2019-01-21 Created: 2019-01-21 Last updated: 2019-01-21Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-6042-9752

Search in DiVA

Show all publications