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Fan, Yanmiao
Publications (2 of 2) Show all publications
Xie, S., Zhou, J., Chen, X., Kong, N., Fan, Y., Hammer, G., . . . Yan, M. (2019). A versatile catalyst-free perfluoroaryl azide-aldehyde-amine conjugation reaction. MATERIALS CHEMISTRY FRONTIERS, 3(2), 251-256
Open this publication in new window or tab >>A versatile catalyst-free perfluoroaryl azide-aldehyde-amine conjugation reaction
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2019 (English)In: MATERIALS CHEMISTRY FRONTIERS, ISSN 2052-1537, Vol. 3, no 2, p. 251-256Article in journal (Refereed) Published
Abstract [en]

In a tri-component reaction, an electrophilically-activated perfluoroaryl azide, an enolizable aldehyde and an amine react readily at room temperature without any catalysts in solvents including aqueous conditions to yield a stable amidine conjugate. The versatility of this reaction is demonstrated in the conjugation of an amino acid without prior protection of the carboxyl group, and in the synthesis of antibiotic-nanoparticle conjugates.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY, 2019
National Category
Materials Chemistry
Identifiers
urn:nbn:se:kth:diva-244534 (URN)10.1039/c8qm00516h (DOI)000457644400009 ()2-s2.0-85060918688 (Scopus ID)
Note

QC 20190403

Available from: 2019-04-03 Created: 2019-04-03 Last updated: 2019-06-25Bibliographically approved
Zhang, Y., Andrén, O. C. J., Nordström, R., Fan, Y., Malmsten, M., Mongkhontreerat, S. & Malkoch, M. (2019). Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics. Advanced Functional Materials, 29(18), Article ID 1806693.
Open this publication in new window or tab >>Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics
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2019 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 29, no 18, article id 1806693Article in journal (Refereed) Published
Abstract [en]

A novel platform of dendritic nanogels is herein presented, capitalizing on the self-assembly of allyl-functional polyesters based on dendritic-linear-dendritic amphiphiles followed by simple cross-linking with complementary monomeric thiols via UV initiated off-stoichiometric thiol-ene chemistry. The facile approach enabled multigram creation of allyl reactive nanogel precursors, in the size range of 190–295 nm, being readily available for further modifications to display a number of core functionalities while maintaining the size distribution and characteristics of the master batch. The nanogels are evaluated as carriers of a spread of chemotherapeutics by customizing the core to accommodate each individual cargo. The resulting nanogels are biocompatible, displaying diffusion controlled release of cargo, maintained therapeutic efficacy, and decreased cargo toxic side effects. Finally, the nanogels are found to successfully deliver pharmaceuticals into a 3D pancreatic spheroids tumor model. © 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Place, publisher, year, edition, pages
Wiley-VCH Verlag, 2019
Keywords
cancer treatment, dendritic nanogel, drug delivery, nanomedicine, 3D modeling, Biocompatibility, Controlled drug delivery, Medical nanotechnology, Oncology, Self assembly, Targeted drug delivery, Core functionality, Diffusion controlled, Linear dendritic, Master batch, Nanogels, Therapeutic efficacy, Thiol-ene chemistries, Toxic side effects, Nanostructured materials
National Category
Materials Chemistry
Identifiers
urn:nbn:se:kth:diva-252526 (URN)10.1002/adfm.201806693 (DOI)2-s2.0-85062732882 (Scopus ID)
Note

QC 20190605

Available from: 2019-06-05 Created: 2019-06-05 Last updated: 2019-06-05Bibliographically approved
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