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Loskutova, K., Grishenkov, D. & Ghorbani, M. (2019). Review on Acoustic Droplet Vaporization in Ultrasound Diagnostics and Therapeutics. BioMed Research International, Article ID 9480193.
Open this publication in new window or tab >>Review on Acoustic Droplet Vaporization in Ultrasound Diagnostics and Therapeutics
2019 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, article id 9480193Article, review/survey (Refereed) Published
Abstract [en]

Acoustic droplet vaporization (ADV) is the physical process in which liquid undergoes phase transition to gas after exposure to a pressure amplitude above a certain threshold. In recent years, new techniques in ultrasound diagnostics and therapeutics have been developed which utilize microformulations with various physical and chemical properties. The purpose of this review is to give the reader a general idea on how ADV can be implemented for the existing biomedical applications of droplet vaporization. In this regard, the recent developments in ultrasound therapy which shed light on the ADV are considered. Modern designs of capsules and nanodroplets (NDs) are shown, and the material choices and their implications for function are discussed. The influence of the physical properties of the induced acoustic field, the surrounding medium, and thermophysical effects on the vaporization are presented. Lastly, current challenges and potential future applications towards the implementation of the therapeutic droplets are discussed.

National Category
Other Medical Engineering
urn:nbn:se:kth:diva-255030 (URN)10.1155/2019/9480193 (DOI)000477811000001 ()31392217 (PubMedID)2-s2.0-85070102699 (Scopus ID)

QC 20190716

Available from: 2019-07-15 Created: 2019-07-15 Last updated: 2020-03-09Bibliographically approved
Ghorbani, M., Olofsson, K., Benjamins, J.-W., Loskutova, K., Paulraj, T., Wiklund, M., . . . Svagan, A. J. (2019). Unravelling the Acoustic and Thermal Responses of Perfluorocarbon Liquid Droplets Stabilized with Cellulose Nanofibers. Langmuir, 35(40), 13090-13099
Open this publication in new window or tab >>Unravelling the Acoustic and Thermal Responses of Perfluorocarbon Liquid Droplets Stabilized with Cellulose Nanofibers
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2019 (English)In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 35, no 40, p. 13090-13099Article in journal (Refereed) Published
Abstract [en]

The attractive colloidal and physicochemical properties of cellulose nanofibers (CNFs) at interfaces have recently been exploited in the facile production of a number of environmentally benign materials, e.g. foams, emulsions, and capsules. Herein, these unique properties are exploited in a new type of CNF-stabilized perfluoropentane droplets produced via a straightforward and simple mixing protocol. Droplets with a comparatively narrow size distribution (ca. 1–5 μm in diameter) were fabricated, and their potential in the acoustic droplet vaporization process was evaluated. For this, the particle-stabilized droplets were assessed in three independent experimental examinations, namely temperature, acoustic, and ultrasonic standing wave tests. During the acoustic droplet vaporization (ADV) process, droplets were converted to gas-filled microbubbles, offering enhanced visualization by ultrasound. The acoustic pressure threshold of about 0.62 MPa was identified for the cellulose-stabilized droplets. A phase transition temperature of about 22 °C was observed, at which a significant fraction of larger droplets (above ca. 3 μm in diameter) were converted into bubbles, whereas a large part of the population of smaller droplets were stable up to higher temperatures (temperatures up to 45 °C tested). Moreover, under ultrasound standing wave conditions, droplets were relocated to antinodes demonstrating the behavior associated with the negative contrast particles. The combined results make the CNF-stabilized droplets interesting in cell-droplet interaction experiments and ultrasound imaging.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2019
National Category
Chemical Process Engineering
urn:nbn:se:kth:diva-259753 (URN)10.1021/acs.langmuir.9b02132 (DOI)000489678500023 ()31549511 (PubMedID)2-s2.0-85072992475 (Scopus ID)

QC 20190917. QC 20191028

Available from: 2019-09-23 Created: 2019-09-23 Last updated: 2020-03-09Bibliographically approved

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