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Flexible and Stretchable Biointerfacing for Healthcare Diagnostics
KTH, School of Electrical Engineering and Computer Science (EECS), Micro and Nanosystems. KTH.ORCID iD: 0000-0001-7769-3931
2019 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Flexible and stretchable wearable biomedical devices provide a platform for continues long-term monitoring of biological signals during neutral body movements thus enabling early intervention and diagnostics of various diseases. This thesis evaluates novel flexible and stretchable bio interfacing medical devices based on microneedle patches and split ring resonator for healthcare diagnostics. Flexible and stretchable microneedle patches were realized by integrating a soft polymer substrate with sharp stainless steel microneedles. This was realized using a magnetic assembly technique. Investigations have shown that the flexible microneedle patch can provide conformal and reliable contact with wrinkles and deformations of the skin. In addition, transdermal monitoring of potassium ions using the proposed flexible microneedle patch have been demonstrated by coating the microneedles with a potassium sensing membrane. Ex-vivo test on the microneedle potassium sensor performed on chicken and porcine skin was able to detect change in potassium concentration in the skin. Furthermore, a novel flexible bio-interface spilt ring resonator (SRR) for the monitoring of intera cranial pressure (ICP) is demonstrated. The sensor was fabricated by depositing a 500 nm gold film on a thermoset thiolene epoxy polymer substrate. The flexible sensor was able to clearly detect the pressure variation that might be an indication of increased ICP in the skull. The proposed methodology of heterogeneous integration of hard materials on a soft and flexible substrate demonstrates a first proof of concept of flexible wearable bio-interfacing devices with vastly different material properties with the potential for continuous and real-time health monitoring.

Place, publisher, year, edition, pages
KTH Royal Institute of Technology, 2019. , p. 36
Series
TRITA-EECS-AVL ; 2019:22
Keywords [en]
Wearable biointerfacing sensor, flexible and stretchable microneedles patch, wearable microneedles device, health and fitness monitoring, minimally invasive ICP monitoring, bioelectronics
National Category
Engineering and Technology
Research subject
Electrical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-245075ISBN: 978-91-7873-128-2 (print)OAI: oai:DiVA.org:kth-245075DiVA, id: diva2:1293950
Presentation
2019-03-27, Q34, Kungliga Tekniska högskolan, Malvinas väg 6, Stockholm, 10:00 (English)
Opponent
Supervisors
Note

QC 20190306

Available from: 2019-03-06 Created: 2019-03-05 Last updated: 2019-10-09Bibliographically approved
List of papers
1. Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing
Open this publication in new window or tab >>Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing
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2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 12, article id e0166330Article in journal (Refereed) Published
Abstract [en]

This paper demonstrates flexible and stretchable microneedle patches that combine soft and flexible base substrates with hard and sharp stainless steel microneedles. An elastomeric polymer base enables conformal contact between the microneedle patch and the complex topography and texture of the underlying skin, while robust and sharp stainless steel microneedles reliably pierce the outer layers of the skin. The flexible microneedle patches have been realized by magnetically assembling short stainless steel microneedles into a flexible polymer supporting base. In our experimental investigation, the microneedle patches were applied to human skin and an excellent adaptation of the patch to the wrinkles and deformations of the skin was verified, while at the same time the microneedles reliably penetrate the surface of the skin. The unobtrusive flexible and stretchable microneedle patches have great potential for transdermal biointerfacing in a variety of emerging applications such as transdermal drug delivery, bioelectric treatments and wearable bio-electronics for health and fitness monitoring.

Place, publisher, year, edition, pages
Public Library of Science, 2016
National Category
Polymer Technologies Medical Biotechnology
Identifiers
urn:nbn:se:kth:diva-199482 (URN)10.1371/journal.pone.0166330 (DOI)000389587100025 ()2-s2.0-85006051781 (Scopus ID)
Note

QC 20170120

Available from: 2017-01-20 Created: 2017-01-09 Last updated: 2019-03-06Bibliographically approved
2. Wearable All-Solid-State Potentiometric Microneedle Patch for Intradermal Potassium Detection
Open this publication in new window or tab >>Wearable All-Solid-State Potentiometric Microneedle Patch for Intradermal Potassium Detection
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2019 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 91, no 2, p. 1578-1586Article in journal (Refereed) Published
Abstract [en]

A new analytical all-solid-state platform for intradermal potentiometric detection of potassium in interstitial fluid is presented here. Solid microneedles are modified with different coatings and polymeric membranes to prepare both the potassium-selective electrode and reference electrode needed for the potentiometric readout. These microneedle-based electrodes are fixed in an epidermal patch suitable for insertion into the skin. The analytical performances observed for the potentiometric cell (Nernstian slope, limit of detection of 10(-4.9) potassium activity, linear range of 10(-4.2) to 10(-1.1), drift of 0.35 +/- 0.28 mV h(-1)), together with a fast response time, adequate selectivity, and excellent reproducibility and repeatability, are appropriate for potassium analysis in interstitial fluid within both clinical and harmful levels. The potentiometric response is maintained after several insertions into animal skin, confirming the resiliency of the microneedle-based sensor. Ex vivo tests based on the intradermal detection of potassium in chicken and porcine skin demonstrate that the microneedle patch is suitable for monitoring potassium changes inside the skin. In addition, the dimensions of the microneedles modified with the corresponding layers necessary to enhance robustness and provide sensing capabilities (1000 mu m length, 45 degrees tip angle, 15 mu m thickness in the tip, and 435 mu m in the base) agree with the required ranges for a painless insertion into the skin. In vitro cytotoxicity experiments showed that the patch can be used for at least 24 h without any side effect for the skin cells. Overall, the developed concept constitutes important progress in the intradermal analysis of ions related to an electrolyte imbalance in humans, which is relevant for the control of certain types of diseases.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC, 2019
National Category
Analytical Chemistry
Identifiers
urn:nbn:se:kth:diva-243957 (URN)10.1021/acs.analchem.8b04877 (DOI)000456350000049 ()30543102 (PubMedID)2-s2.0-85059747630 (Scopus ID)
Note

QC 20190301

Available from: 2019-03-01 Created: 2019-03-01 Last updated: 2019-03-06Bibliographically approved
3. Initial in-vitro trial for intra-cranial pressure monitoring using subdermal proximity-coupled split-ring resonator
Open this publication in new window or tab >>Initial in-vitro trial for intra-cranial pressure monitoring using subdermal proximity-coupled split-ring resonator
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2018 (English)In: IMBioc 2018 - 2018 IEEE/MTT-S International Microwave Biomedical Conference, Institute of Electrical and Electronics Engineers (IEEE), 2018, p. 73-75, article id 8428854Conference paper, Published paper (Refereed)
Abstract [en]

Intra cranial pressure (ICP) monitoring is used in treating severe traumatic brain injury (TBI) patients. All current clinical available measurement methods are invasive presenting considerable social costs. This paper presents a preliminary investigation of the feasibility of ICP monitoring using an innovative microwave-based non-invasive approach. A phantom mimicking the dielectric characteristics of human tissues of the upper part of the head at low microwave frequencies is employed together to a proof-of-concept prototype based on the proposed approach consisting in a readout system and a sub-dermally implanted passive device, both based in split ring resonator techniques. This study shows the potential of our approach to detect two opposite pressure variation stages inside the skull. The employed phantom model needs to be improved to support finer variations in the pressure and better phantom parts, principally for the skull mimic and the loss tangent of all mimics.

Place, publisher, year, edition, pages
Institute of Electrical and Electronics Engineers (IEEE), 2018
Keywords
Biocompatible, Intra cranial pressure, Microwave technique, Split ring resonator (SRR) sensor
National Category
Other Medical Engineering
Identifiers
urn:nbn:se:kth:diva-234095 (URN)10.1109/IMBIOC.2018.8428854 (DOI)2-s2.0-85052400710 (Scopus ID)9781538659182 (ISBN)
Conference
2018 IEEE/MTT-S International Microwave Biomedical Conference, IMBioc 2018, Pennsylvania Convention CenterPhiladelphia, United States, 14 June 2018 through 15 June 2018
Note

QC 20180905

Available from: 2018-09-05 Created: 2018-09-05 Last updated: 2019-03-06Bibliographically approved

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