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Cardenolides: Insights from chemical structure and pharmacological utility
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Chemistry.
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2019 (English)In: Pharmacological Research, ISSN 1043-6618, E-ISSN 1096-1186, Vol. 141, p. 123-175Article in journal (Refereed) Published
Abstract [en]

Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na + /K + -ATPase enzyme, and they are regarded as an effective treatment for congestive heart failure (CHF), cardiac arrhythmia and atrial fibrillation. Furthermore, increasing evidence has indicated the potential cytotoxic effects of CGs against various types of cancer. In this review, we highlight some of the structural features of this class of natural products that are crucial for their efficacy, some methods of isolating these compounds from natural resources, and the structural elucidation tools that have been used. We also describe their physicochemical properties and several modern biotechnological approaches for preparing CGs that do not require plant sources.

Place, publisher, year, edition, pages
Academic Press , 2019. Vol. 141, p. 123-175
Keywords [en]
Cardiac glycosides, Chemical property space, Heart failure, Isolation, cardenolide derivative, biotechnological production, drug activity, drug efficacy, drug structure, drug synthesis, human, nonhuman, physical chemistry, priority journal, Review
National Category
Industrial Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-248153DOI: 10.1016/j.phrs.2018.12.015ISI: 000460997000011Scopus ID: 2-s2.0-85059076951OAI: oai:DiVA.org:kth-248153DiVA, id: diva2:1306852
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QC 20190425

Available from: 2019-04-25 Created: 2019-04-25 Last updated: 2019-04-25Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
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Language
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  • Other locale
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Output format
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