The joint design of control and communication scheduling in a Networked Control System (NCS) is known to be a hard problem. Several research works have successfully designed optimal sampling and/or control strategies under simplified communication models, where transmission delays/times are negligible or fixed. However, considering sophisticated communication models, with random transmission times, result in highly coupled and difficult-to-solve optimal design problems due to the parameter inter-dependencies between estimation/control and communication layers. To tackle this problem, in this work, we investigate the applicability of Age-of-Information (AoI) for solving control/estimation problems in an NCS under i.i.d. transmission times. Our motivation for this investigation stems from the following facts: 1) recent results indicate that AoI can be tackled under relatively sophisticated communication models, and 2) a lower AoI in an NCS may result in a lower estimation/control cost. We study a joint optimization of sampling and scheduling for a single-loop stochastic LTI networked system with the objective of minimizing the time-average squared norm of the estimation error. We first show that, under mild assumptions on information structure the optimal control policy can be designed independently from the sampling and scheduling policies. We then derive a key result that minimizing the estimation error is equivalent to minimizing a non-negative and non-decreasing function of AoI. The parameters of this function include the LTI matrix and the covariance of exogenous noise in the LTI system. Noting that the formulated problem is a stochastic combinatorial optimization problem and is hard to solve, we resort to heuristic algorithms by extending existing algorithms in the AoI literature. We also identify a class of LTI system dynamics for which minimizing the estimation error is equivalent to minimizing the expected AoI.