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Mechanical characterisation of the human dura mater, falx cerebri and superior sagittal sinus
Univ Limerick, Bernal Inst, Limerick, Ireland.;Univ Limerick, Sch Engn, Limerick, Ireland..
Univ Limerick, Bernal Inst, Limerick, Ireland.;Univ Limerick, Sch Engn, Limerick, Ireland..
Univ Limerick, Bernal Inst, Limerick, Ireland.;Univ Limerick, Sch Engn, Limerick, Ireland.;Univ Limerick, Hlth Res Inst, Limerick, Ireland..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Neuronic Engineering.ORCID iD: 0000-0002-3910-0418
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2021 (English)In: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 134, p. 388-400Article in journal (Refereed) Published
Abstract [en]

The cranial meninges have been shown to play a pivotal role in traumatic brain injury mechanopathology. However, while the mechanical response of the brain and its many subregions have been studied extensively, the meninges have conventionally been overlooked. This paper presents the first comparative mechanical analysis of human dura mater, falx cerebri and superior sagittal sinus tissues. Biaxial tensile analysis identified that these tissues are mechanically heterogeneous, in contrast to the assumption that the tissues are mechanically homogeneous which is typically employed in FE model design. A thickness of 0.91 +/- 0.05 (standard error) mm for the falx cerebri was also identified. This data can aid in improving the biofidelity of the influential falx structure in FE models. Additionally, the use of a collagen hybridizing peptide on the superior sagittal sinus suggests this structure is particularly susceptible to the effects of circumf erential stretch, which may have important implications for clinical treatment of dural venous sinus pathologies. Collectively, this research progresses understanding of meningeal mechanical and structural characteristics and may aid in elucidating the behaviour of these tissues in healthy and diseased conditions.

Place, publisher, year, edition, pages
Elsevier BV , 2021. Vol. 134, p. 388-400
Keywords [en]
Traumatic brain injury (TBI), Biomechanics, Meninges, Collagen hybridizing peptide (CHP), Structural damage analysis
National Category
Physiology
Identifiers
URN: urn:nbn:se:kth:diva-304703DOI: 10.1016/j.actbio.2021.07.043ISI: 000709954800001PubMedID: 34314888Scopus ID: 2-s2.0-85111679607OAI: oai:DiVA.org:kth-304703DiVA, id: diva2:1610297
Note

QC 20211110

Available from: 2021-11-10 Created: 2021-11-10 Last updated: 2022-06-25Bibliographically approved

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