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A transfer learning approach for multiclass classification of Alzheimer's disease using MRI images
Zhejiang Normal Univ, Dept Comp Sci & Math, Jinhua, Peoples R China..
Huazhong Univ Sci & Technol, Sch Comp Sci, Wuhan, Peoples R China..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Medical Imaging. Natl Univ Modern Languages, Dept Comp Sci, Islamabad, Pakistan..ORCID iD: 0000-0002-8905-8510
Univ Agr Faisalabad, Dept Comp Sci, Sub Campus Burewala Vehari, Faisalabad, Pakistan..
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2023 (English)In: Frontiers in Neuroscience, ISSN 1662-4548, E-ISSN 1662-453X, Vol. 16, article id 1050777Article in journal (Refereed) Published
Abstract [en]

Alzheimer's is an acute degenerative disease affecting the elderly population all over the world. The detection of disease at an early stage in the absence of a large-scale annotated dataset is crucial to the clinical treatment for the prevention and early detection of Alzheimer's disease (AD). In this study, we propose a transfer learning base approach to classify various stages of AD. The proposed model can distinguish between normal control (NC), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI), and AD. In this regard, we apply tissue segmentation to extract the gray matter from the MRI scans obtained from the Alzheimer's Disease National Initiative (ADNI) database. We utilize this gray matter to tune the pre-trained VGG architecture while freezing the features of the ImageNet database. It is achieved through the addition of a layer with step-wise freezing of the existing blocks in the network. It not only assists transfer learning but also contributes to learning new features efficiently. Extensive experiments are conducted and results demonstrate the superiority of the proposed approach.

Place, publisher, year, edition, pages
Frontiers Media SA , 2023. Vol. 16, article id 1050777
Keywords [en]
Alzheimer's disease, multiclass classification, deep learning, MRI, early diagnosis of AD
National Category
Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-323918DOI: 10.3389/fnins.2022.1050777ISI: 000919387000001PubMedID: 36699527Scopus ID: 2-s2.0-85146940419OAI: oai:DiVA.org:kth-323918DiVA, id: diva2:1738862
Note

QC 20231122

Available from: 2023-02-23 Created: 2023-02-23 Last updated: 2025-02-09Bibliographically approved

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Mehmood, Atif

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