A transfer learning approach for multiclass classification of Alzheimer's disease using MRI imagesShow others and affiliations
2023 (English)In: Frontiers in Neuroscience, ISSN 1662-4548, E-ISSN 1662-453X, Vol. 16, article id 1050777
Article in journal (Refereed) Published
Abstract [en]
Alzheimer's is an acute degenerative disease affecting the elderly population all over the world. The detection of disease at an early stage in the absence of a large-scale annotated dataset is crucial to the clinical treatment for the prevention and early detection of Alzheimer's disease (AD). In this study, we propose a transfer learning base approach to classify various stages of AD. The proposed model can distinguish between normal control (NC), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI), and AD. In this regard, we apply tissue segmentation to extract the gray matter from the MRI scans obtained from the Alzheimer's Disease National Initiative (ADNI) database. We utilize this gray matter to tune the pre-trained VGG architecture while freezing the features of the ImageNet database. It is achieved through the addition of a layer with step-wise freezing of the existing blocks in the network. It not only assists transfer learning but also contributes to learning new features efficiently. Extensive experiments are conducted and results demonstrate the superiority of the proposed approach.
Place, publisher, year, edition, pages
Frontiers Media SA , 2023. Vol. 16, article id 1050777
Keywords [en]
Alzheimer's disease, multiclass classification, deep learning, MRI, early diagnosis of AD
National Category
Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-323918DOI: 10.3389/fnins.2022.1050777ISI: 000919387000001PubMedID: 36699527Scopus ID: 2-s2.0-85146940419OAI: oai:DiVA.org:kth-323918DiVA, id: diva2:1738862
Note
QC 20231122
2023-02-232023-02-232025-02-09Bibliographically approved