Mitigating and adapting to increasing flood risk driven by climate change and growing urbanization is still a challenge for humanity. Over the last decades, the Nature Based Solutions (NBS) approach has received increasing interest from governments, academia and society, but its implementation is still in its infancy. This volume presented an up-to-date compilation about the current knowledge on NBS regarding their potential to mitigate several types of floods recorded in different environments, the associated advantages and limitations, and the barriers affecting their wider implementation. This concluding chapter provides a synthesis of the main messages of the chapters included in this volume, and it highlights the relevant aspects that must be considered for an effective and broader application of NBS. In this regard, particular attention is given to the need to maximize their multifunctionality and to consider the transdisciplinary nature of the NBS approach.