In hot climates, such as sub-Sahara Africa, window sizing and orientation pose challenges as they add, through solar insolation, to the building cooling energy demand and thus the cause of indoor overheating risk. This risk can be reduced through passive building-design-integrated measures, e.g., optimizing the window size, orientation and solar shading strategies. Through an IDA-ICE building performance simulation tool, the current study explores the impact of window size, optimization and building-integrated PV panels as shading strategies on cooling energy demands in three cities (Niamey, Nairobi and Harare) in sub-Sahara Africa. Results show that thermal comfort and cooling energy demand are sensitive to a window-to-wall ratio (WWR) > 70%, while the need for artificial lighting is negligible for a WWR > 50%, particularly in the north for cities in the Southern hemisphere and the south in the Northern hemisphere. A WWR > 70% in the east and west should be avoided unless shading devices are incorporated. Internal blinds perform better in improving occupant thermal comfort but increase artificial lighting while integrating PV panels, as external shading overhangs reduce cooling energy but also produce energy that can be utilized for building services, such as air conditioning. In this study, the results and implications of the optimization of window size, orientation and building-integrated shading and operation are discussed.