Digitalisation-related challenges and opportunities in higher education are not new, but awareness of their transformative potential has increased, with global trends including massive open online courses (MOOCs) and other forms of technology-enhanced open education. The COVID-19 pandemic has emphasised the importance of flexible forms of teaching and learning, and, as a result, has intensified the adoption of technological platforms and solutions across the board. In this introductory chapter to the volume, the editors provide a state of the art on the topic of digital transformations, including clarifications on concepts and definitions, alongside the articulation of a systemic framework that considers the complexity, dynamic, and multifaceted nature of the phenomenon under investigation.