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Effects of surface morphology and composition of titanium implants on osteogenesis and inflammatory responses: a review
Shandong Univ, Natl Demonstrat Ctr Expt Mech Engn Educ, Sch Mech Engn, Key Lab High Efficiency & Clean Mfg, Jinan, Peoples R China..
Shandong Univ, Natl Demonstrat Ctr Expt Mech Engn Educ, Sch Mech Engn, Key Lab High Efficiency & Clean Mfg, Jinan, Peoples R China..
Shandong First Med Univ, Coll Artificial Intelligence & Big Data Med Sci, Tai An, Peoples R China..
Univ Coll Dublin, Ctr Micro Nano Mfg Technol MNMT Dublin, Sch Mech & Mat Engn, Dublin, Ireland..
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2023 (English)In: Biomedical Materials, ISSN 1748-6041, E-ISSN 1748-605X, Vol. 18, no 4, article id 042002Article, review/survey (Refereed) Published
Abstract [en]

Titanium and its alloys have been widely used in bone tissue defect treatment owing to their excellent comprehensive properties. However, because of the biological inertness of the surface, it is difficult to achieve satisfactory osseointegration with the surrounding bone tissue when implanted into the body. Meanwhile, an inflammatory response is inevitable, which leads to implantation failure. Therefore, solving these two problems has become a new research hotspot. In current studies, various surface modification methods were proposed to meet the clinical needs. Yet, these methods have not been classified as a system to guide the follow-up research. These methods are demanded to be summarized, analyzed, and compared. In this manuscript, the effect of physical signal regulation (multi-scale composite structure) and chemical signal regulation (bioactive substance) generated by surface modification in promoting osteogenesis and reducing inflammatory responses was generalized and discussed. Finally, from the perspective of material preparation and biocompatibility experiments, the development trend of surface modification in promoting titanium implant surface osteogenesis and anti-inflammatory research was proposed.

Place, publisher, year, edition, pages
IOP Publishing , 2023. Vol. 18, no 4, article id 042002
Keywords [en]
titanium implants, multi-scale composite structures, bioactive substances, osteogenesis, inflammatory responses
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:kth:diva-330508DOI: 10.1088/1748-605X/acd976ISI: 001007534400001PubMedID: 37236200OAI: oai:DiVA.org:kth-330508DiVA, id: diva2:1777879
Note

QC 20230630

Available from: 2023-06-30 Created: 2023-06-30 Last updated: 2023-06-30Bibliographically approved

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Wang, Teng

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