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Randomized iterative spherical‐deconvolution informed tractogram filtering
Saarland University, Faculty of Mathematics and Computer Science, Campus E1.7, Saarbruecken, 66041, Saarland, Germany.
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems. Division of Brain, Imaging, and Behaviour, Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.ORCID iD: 0000-0002-6827-9162
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Biomedical Engineering and Health Systems, Medical Imaging.ORCID iD: 0000-0001-5765-2964
2023 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 278, article id 120248Article in journal (Refereed) Published
Abstract [en]

Tractography has become an indispensable part of brain connectivity studies. However, it is currently facing problems with reliability. In particular, a substantial amount of nerve fiber reconstructions (streamlines) in tractograms produced by state-of-the-art tractography methods are anatomically implausible. To address this problem, tractogram filtering methods have been developed to remove faulty connections in a postprocessing step. This study takes a closer look at one such method, Spherical-deconvolution Informed Filtering of Tractograms (SIFT), which uses a global optimization approach to improve the agreement between the remaining streamlines after filtering and the underlying diffusion magnetic resonance imaging data. SIFT is not suitable for judging the compliance of individual streamlines with the acquired data since its results depend on the size and composition of the surrounding tractogram. To tackle this problem, we propose applying SIFT to randomly selected tractogram subsets in order to retrieve multiple assessments for each streamline. This approach makes it possible to identify streamlines with very consistent filtering results, which were used as pseudo-ground truths for training classifiers. The trained classifier is able to distinguish the obtained groups of complying and non-complying streamlines with the acquired data with an accuracy above 80%.

Place, publisher, year, edition, pages
Academic Press Inc. , 2023. Vol. 278, article id 120248
Keywords [en]
Diffusion MRI, Machine learning, Tractogram filtering, Tractography
National Category
Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-334341DOI: 10.1016/j.neuroimage.2023.120248ISI: 001043928700001PubMedID: 37423271Scopus ID: 2-s2.0-85165227384OAI: oai:DiVA.org:kth-334341DiVA, id: diva2:1789816
Note

QC 20230821

Available from: 2023-08-21 Created: 2023-08-21 Last updated: 2025-02-09Bibliographically approved

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Jörgens, DanielMoreno, Rodrigo

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