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A battery-less implantable glucose sensor based on electrical impedance spectroscopy
Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
KTH, School of Electrical Engineering and Computer Science (EECS), Electrical Engineering, Electronics and Embedded systems. (Mixed Signal ICs & Systems)ORCID iD: 0000-0001-7549-0858
Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.ORCID iD: 0000-0002-7983-925X
Prevas AB, Stockholm, Sweden.
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2023 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 13, no 1, article id 18122Article in journal (Refereed) Published
Abstract [en]

The ability to perform accurate continuous glucose monitoring without blood sampling has revolutionised the management of diabetes. Newer methods that can allow measurements during longer periods are necessary to substantially improve patients’ quality of life. This paper presents an alternative method for glucose monitoring which is based on electrical impedance spectroscopy. A battery-less implantable bioimpedance spectroscope was designed, built, and used in an in vivo study on pigs. After a recovery period of 14 days post surgery, a total of 236 subcutaneous bioimpedance measurements obtained from intravenous glucose tolerance tests, with glucose concentration ranges between 77.4 and 523.8 mg/dL, were analyzed. The results show that glucose concentrations estimated by subcutaneous bioimpedance measurements correlate very well to the blood glucose reference values. The pigs were clinically healthy throughout the study, and the postmortem examinations revealed no signs of adverse effects related to the sensor. The implantation of the sensor requires minor surgery. The implant, being externally powered, could in principle last indefinitely. These encouraging results demonstrate the potential of the bioimpedance method to be used in future continuous glucose monitoring systems.

Place, publisher, year, edition, pages
Springer Nature , 2023. Vol. 13, no 1, article id 18122
National Category
Medical Equipment Engineering
Research subject
Technology and Health
Identifiers
URN: urn:nbn:se:kth:diva-338925DOI: 10.1038/s41598-023-45154-8ISI: 001087271600078PubMedID: 37872272Scopus ID: 2-s2.0-85174690457OAI: oai:DiVA.org:kth-338925DiVA, id: diva2:1808280
Funder
Swedish Foundation for Strategic Research, ITM17-0079
Note

This work was partially funded by D.T.R.  Dermal Therapy Research Inc of Canada and the Swedish Foundation for Strategic Research (SSF) under project number ITM17-0079. 

QC 20240102

Available from: 2023-10-30 Created: 2023-10-30 Last updated: 2024-01-02

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Fernández Schrunder, AlejandroRusu, AnaRodriguez, Saul

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