Verification and Validation (V&V) is the foremost analysis which is carried out for evaluation of the accuracy level and dependability of computational fluid dynamic (CFD) simulations. The present study investigates the V&V of CFD models in predicting the dynamic trim and hull resistance of high-speed planing hulls with an aim to provide a deeper understanding of V&V analysis in this specific field of application. Two different planing hulls, namely the C05 stepped hull and the C1 interceptor hull, are analyzed with four different grids and time-steps using two mesh motion techniques, namely overset and morphing approach. The discretization (grid) and time-step uncertainties for each CFD simulation are estimated using the least squares method. The results indicate that the overset mesh approach performs better than the morphing grid method in terms of numerical uncertainty and validation achieved for both hulls. The error of both techniques in the prediction of resistance and trim angle of the boat shows an acceptable range of accuracy. The findings provide valuable insights for simulation-based designing and optimizing high-speed planing hulls, specifically by identifying the optimal mesh technique, cell number, and time-step for accurate prediction of wetted surface shape, ventilation formation, running attitude, and resistance.