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Angiogenesis in bone tissue engineering via ceramic scaffolds: A review of concepts and recent advancements
Department of Dentistry, Kashan University of Medical Science, Kashan, Iran.
School of Metallurgy & Materials Engineering, Iran University of Science and Technology, Tehran, Iran.
Department of Materials Science & Engineering, Sharif University of Technology, Tehran, Iran.
Department of Materials Science & Engineering, Sharif University of Technology, Tehran, Iran.
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2024 (English)In: Biomaterials Advances, E-ISSN 2772-9508, Vol. 159, article id 213828Article, review/survey (Refereed) Published
Abstract [en]

Due to organ donor shortages, long transplant waitlists, and the complications/limitations associated with auto and allotransplantation, biomaterials and tissue-engineered models are gaining attention as feasible alternatives for replacing and reconstructing damaged organs and tissues. Among various tissue engineering applications, bone tissue engineering has become a promising strategy to replace or repair damaged bone. We aimed to provide an overview of bioactive ceramic scaffolds in bone tissue engineering, focusing on angiogenesis and the effect of different biofunctionalization strategies. Different routes to angiogenesis, including chemical induction through signaling molecules immobilized covalently or non-covalently, in situ secretion of angiogenic growth factors, and the degradation of inorganic scaffolds, are described. Physical induction mechanisms are also discussed, followed by a review of methods for fabricating bioactive ceramic scaffolds via microfabrication methods, such as photolithography and 3D printing. Finally, the strengths and weaknesses of the commonly used methodologies and future directions are discussed.

Place, publisher, year, edition, pages
Elsevier BV , 2024. Vol. 159, article id 213828
Keywords [en]
Angiogenesis, Bioceramic, Biofabrication, Biofunctionalization, Bone tissue engineering, Ceramic scaffolds
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:kth:diva-344548DOI: 10.1016/j.bioadv.2024.213828Scopus ID: 2-s2.0-85187225615OAI: oai:DiVA.org:kth-344548DiVA, id: diva2:1845936
Note

QC 20240321

Available from: 2024-03-20 Created: 2024-03-20 Last updated: 2024-03-21Bibliographically approved

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Toprak, Muhammet

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