Kelvin-cell foam structure has the potential for noise and vibration control applications in microsystems. Previous studies show that different geometries of Kelvin-cell foams affect their mechanical properties. In this study, we investigate the effect of different load conditions on the vibro-acoustic behavior of Kelvin-cell foam. Five types of Kelvin-cell foam with different geometry parameters are simulated under a series of mass loads. The results of mode shapes show that at the first resonance frequency, the behavior of Kelvin-cell foam is similar to spring. Therefore, with the mass load, the Kelvin-cell foam can be analogized to a mass-spring system, and the equivalent elastic modulus can be derived from the frequency response of velocity transmission. This study can be the base for the optimization of Kelvin-cell foams to be used in vibration control in microsystems.