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Physics-Inspired Generative Models in Medical Imaging
KTH, School of Engineering Sciences (SCI), Physics, Particle Physics, Astrophysics and Medical Imaging. MedTechLabs, Karolinska University Hospital, Stockholm, Sweden.ORCID iD: 0000-0001-7051-6625
Faculty of Informatics and Data Science, University of Regensburg, Regensburg, Germany.
Faculty of Informatics and Data Science, University of Regensburg, Regensburg, Germany.
Department of Biomedical Engineering, School of Engineering, Biomedical Imaging Center, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.
2025 (English)In: Annual Review of Biomedical Engineering, ISSN 1523-9829, E-ISSN 1545-4274, Vol. 27, no 1, p. 499-525Article, review/survey (Refereed) Published
Abstract [en]

Physics-inspired generative models (GMs), in particular diffusion models and Poisson flow models, enhance Bayesian methods and promise great utility in medical imaging. This review examines the transformative role of such generative methods. First, a variety of physics-inspired GMs, including denoising diffusion probabilistic models, score-based diffusion models, and Poisson flow generative models (including PFGM++), are revisited, with an emphasis on their accuracy, robustness and acceleration. Then, major applications of physics-inspired GMs in medical imaging are presented, comprising image reconstruction, image generation, and image analysis. Finally, future research directions are brainstormed, including unification of physics-inspired GMs, integration with vision-language models, and potential novel applications of GMs. Since the development of generative methods has been rapid, it is hoped that this review will give peers and learners a timely snapshot of this new family of physics-driven GMs and help capitalize their enormous potential for medical imaging.

Place, publisher, year, edition, pages
Annual Reviews , 2025. Vol. 27, no 1, p. 499-525
Keywords [en]
Bayesian theorem, consistency model, diffusion model, image analysis, image reconstruction, image/data synthesis, medical imaging, PFGM++, physics-inspired generative models, Poisson flow generative model
National Category
Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-363748DOI: 10.1146/annurev-bioeng-102723-013922ISI: 001491920300020PubMedID: 40310888Scopus ID: 2-s2.0-105004481565OAI: oai:DiVA.org:kth-363748DiVA, id: diva2:1959843
Note

QC 20250522

Available from: 2025-05-21 Created: 2025-05-21 Last updated: 2025-07-03Bibliographically approved

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Hein, Dennis

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