Control applications over wireless sensor networks (WSNs) require timely, reliable, and energy efficient communications. Cross-layer interaction is an essential design paradigm to exploit the complex interaction among the layers of the protocol stack and reach a maximum efficiency. Such a design approach is challenging because reliability and latency of delivered packets and energy are at odds, and resource constrained nodes support only simple algorithms. In this paper, the TREnD protocol is introduced for control applications over WSNs in industrial environments. It is a cross-layer protocol that embraces efficiently routing algorithm, MAC, data aggregation, duty cycling, and radio power control. The protocol parameters are adapted by an optimization problem, whose objective function is the network energy consumption, and the constraints are the reliability and latency of the packets. TREnD uses a simple algorithm that allows the network to meet the reliability and latency required by the control application while minimizing for energy consumption. TREnD is implemented on a test-bed and compared to some existing protocols. Experimental results show good performance in terms of reliability, latency, low duty cycle, and load balancing for both static and time-varying scenarios.