Multiple sphere formations are studied for Reynolds numbers of 100 − 300 in order to better understand the hydrodyanmicalinteraction among spheres. Spheres placed in tandem, diagonal as well as cluster formations including3–5 spheres are investigated using a conventional finite difference method where the Volume of Solid (VOS) methodis used to represent the spherical particles. The results show that, independent of sphere formation, an overall trend isthat the front spheres are the least affected by the inclusion of additional spheres in the formation. Although spherecharacteristics depending on position within a formation is found, the behavior of the trailing spheres changes withformation type, number of spheres, separation distances and Reynolds numbers.