Within this paper, a process for the design of a multifunctional sandwich body panel for vehicle applications is proposed. The method, presented with a case study, attempts to achieve a balance between structural and acoustic performance using numerical tools for topology optimization and combined size and property optimization. The goal of the work is to achieve an optimal distribution of traditional sandwich foam material and light weight acoustic foam within the core of the panel. The significance of the coupling between the panels inner face sheet and the acoustic foam is examined and proves to be a critical parameter in the design. An adaptation to existing topology optimization schemes is proposed to deal with the presence or absence of such a coupling. The results show promise in simplifying construction, reducing weight, and streamlining the assembly process.