We consider the use of space diversity methods in conjunction withinterference rejection combining (IRC) to mitigate the impact of interferenceand noise for interference limited scenarios. The use of transmit diversityschemes in a system generally limits the interference rejection capabilities of IRC techniques. We introduce a novel space-time IRC (STIRC) scheme that exploits the spatio-temporal correlation induced by cochannel users employingtransmit diversity in the form of space-time block codes (STBC). Thus, thesystem can draw upon the benefits of interference rejection methods althoughtransmit diversity is being employed. Simulation examples are presented to illustrate the discussion and to highlight the importance of taking both the spatial and temporal structure of the interference into account.