The operation of groups of heavy-duty vehicles at close intervehicular distances (known as platoons) has been shown to be an effective way of reducing fuel consumption. For single vehicles, it is also known that the availability of preview information on the road topography can be exploited to obtain fuel savings. The current paper aims at the inclusion of preview information in platooning by introducing a two-layer control system architecture for so-called look-ahead platooning. Here, the layers are responsible for the inclusion of preview information and real-time vehicle control for platooning, respectively. Within this framework, a control strategy is presented, where dynamic programming is used for the calculation of fuel-optimal speed profiles, while a model predictive control approach is exploited for the real-time vehicle control. The feasibility of this approach is illustrated by means of the simulation of relevant scenarios.