The monitoring and control of low voltage distribution grids has historically been disregarded due to the unidirectional flow of power. However, nowadays the massive integration of distributed energy resources into distribution grids, such as solar photovoltaics, distributed storage, electric vehicles and demand response programs, presents some challenges. For instance, the unidirectional top-down power flow is being replaced by power flows in any direction: top-down and bottom-up. This paradigm shift adds extra regulatory, economic, and technical complexity for the Distribution System Operators (DSO). Thus to overcome the possible operational constraints, thermal limits, or voltage problems in the grid, an update of the existing electricity infrastructures is required. In response to this new situation, this thesis investigates the cost-effective communication and control architectures that are required for active low voltage grid monitoring and control applications, considering the regulatory constraints and the efficient utilization of the assets from a DSO’s perspective. The solutions include: i) optimal sensor placement configuration to perform low voltage state estimation, ii) optimal metering infrastructure designs for active low voltage monitoring applications, iii) coordinated control strategies to allow the integration of microgrid-like structures into the distribution grids, iv) optimal placement of actuators for operating the control strategies, v) a multiagent-based control solution for self-healing and feeder reconfiguration applications, and vi) a framework model and simulations to assess the reliability of the ICT infrastructure that enables the monitoring and control applications. As concluding remark, since the deployment of technology at low voltage grids is restricted to assets owned by the DSO, the operability of the grid is limited. This condition makes it so that the required communication and control enhancement solutions shall prioritize cost-effectiveness over comprehensiveness and complexity. Thus, the results from the presented studies show that it is essential to perform thorough cost-benefit analyses of the potential improvement solutions for each grid, because this will allow deploying the right technology only at the necessary locations.