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Microfluidics for cell factory and bioprocess development
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Nano Biotechnology.ORCID iD: 0000-0002-3722-5970
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Nano Biotechnology.ORCID iD: 0000-0001-5232-0805
2019 (English)In: Current Opinion in Biotechnology, ISSN 0958-1669, E-ISSN 1879-0429, Vol. 55, p. 95-102Article in journal (Refereed) Published
Abstract [en]

Bioindustry is expanding to an increasing variety of food, chemical and pharmaceutical products, each requiring rapid development of a dedicated cell factory and bioprocess. Microfluidic tools are, together with tools from synthetic biology and metabolic modeling, being employed in cell factory and bioprocess development to speed up development and address new products. Recent examples of microfluidics for bioprocess development range from integrated devices for DNA assembly and transformation, to high throughput screening of cell factory libraries, and micron scale bioreactors for process optimization. These improvements act to improve the biotechnological engineering cycle with tools for building, testing and evaluating cell factories and bioprocesses by increasing throughput, parallelization and automation.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 55, p. 95-102
Keywords [en]
Cells, Cytology, Drug products, Microfluidics, Optimization, Bioprocess development, DNA assemblies, High throughput screening, Integrated device, Metabolic modeling, Parallelizations, Pharmaceutical products, Synthetic biology, Cell engineering, bioprocess, biotechnological procedures, cell factory, cell growth, cell population, cell selection, cell separation, priority journal, process optimization, Review, single cell analysis
National Category
Industrial Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-236324DOI: 10.1016/j.copbio.2018.08.011ISI: 000459949400015Scopus ID: 2-s2.0-85053411311OAI: oai:DiVA.org:kth-236324DiVA, id: diva2:1264401
Funder
Novo NordiskKnut and Alice Wallenberg FoundationSwedish Research Council Formas
Note

QC 20181120

Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2019-11-26Bibliographically approved

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Björk, SaraJönsson, Håkan

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