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Mannose-binding lectin does not explain the dismal prognosis after an acute coronary event in dysglycaemic patients: A report from the GAMI cohort
Karolinska Inst, Dept Med Solna, Solnavagen 1, S-17176 Stockholm, Sweden..
Karolinska Inst, Dept Med Solna, Solnavagen 1, S-17176 Stockholm, Sweden..
Aarhus Univ, Dept Clin Med, Med Steno Aarhus Res Lab, Aarhus, Denmark..
Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark..
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2022 (English)In: Cardiovascular Diabetology, E-ISSN 1475-2840, Vol. 21, no 1, article id 129Article in journal (Refereed) Published
Abstract [en]

Background Mannose binding lectin (MBL) has been suggested to be associated with an impaired cardiovascular prognosis in dysglycaemic conditions, but results are still contrasting. Our aims are (i) to examine whether MBL levels differ between patients with an acute myocardial infarction (MI) and healthy controls and between subgroups with different glucose tolerance status, and (ii) to investigate the relation between MBL and future cardiovascular events. Methods MBL levels were assessed at discharge and after 3 months in 161 AMI patients without any previously known glucose perturbations and in 183 age- and gender-matched controls from the Glucose metabolism in patients with Acute Myocardial Infarction (GAMI) study. Participants were classified as having dysglycaemia, i.e. type 2 diabetes or impaired glucose tolerance, or not by an oral glucose tolerance test. The primary outcome was a composite of cardiovascular events comprising cardiovascular death, AMI, stroke or severe heart failure during 11 years of follow-up. Total and cardiovascular mortality served as secondary outcomes. Results At hospital discharge patients had higher MBL levels (median 1246 mu g/L) than three months later (median 575 mu g/L; p < 0.01), the latter did not significantly differ from those in the controls (801 mu g/L; p = 0.47). MBL levels were not affected by dysglycaemia either in patients or controls. Independent of glycaemic state, increasing MBL levels did not predict any of the studied outcomes in patients. In unadjusted analyses increasing MBL levels predicted cardiovascular events (hazard ratio HR: 1.67, 95% confidence interval CI 1.06-2.64) and total mortality (HR 1.53, 95% CI 1.12-2.10) in the control group. However, this did not remain in adjusted analyses. Conclusions Patients had higher MBL levels than controls during the hospital phase of AMI, supporting the assumption that elevated MBL reflects acute stress. MBL was not found to be independently associated with cardiovascular prognosis in patients with AMI regardless of glucose state.

Place, publisher, year, edition, pages
Springer Nature , 2022. Vol. 21, no 1, article id 129
Keywords [en]
Dysglycaemia, Cardiovascular disease, Inflammation, Complement system proteins, Mannose binding lectin, Biomarker, Prognosis
National Category
Endocrinology and Diabetes
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URN: urn:nbn:se:kth:diva-315841DOI: 10.1186/s12933-022-01562-0ISI: 000822341600001PubMedID: 35804351Scopus ID: 2-s2.0-85133662189OAI: oai:DiVA.org:kth-315841DiVA, id: diva2:1684126
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QC 20220721

Available from: 2022-07-21 Created: 2022-07-21 Last updated: 2024-07-04Bibliographically approved

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