Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Translocation mechanism of C-60 and C-60 derivations across a cell membrane
KTH, Skolan för bioteknologi (BIO), Teoretisk kemi och biologi.
2016 (engelsk)Inngår i: Journal of nanoparticle research, ISSN 1388-0764, E-ISSN 1572-896X, Vol. 18, nr 11Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Carbon-based nanoparticles (NPs) such as fullerenes and nanotubes have been extensively studied for drug delivery in recent years. The permeation process of fullerene and its derivative molecules through membrane is essential to the utilization of fullerene-based drug delivery system, but the mechanism and the dynamics of permeation through cell membrane are still unclear. In this study, coarse-grained molecular dynamics simulations were performed to investigate the permeation process of functionalized fullerene molecules (ca. 0.72 nm) through the membrane. Our results show that single functionalized fullerene molecule in such nanoscale could permeate the lipid membrane in micro-second time scale. Pristine C-60 molecules prefer to aggregate into several small clusters while C60OH15 molecules could aggregate into one big cluster to permeate through the lipid membrane. After permeation of C-60 or its derivatives into membrane, all C-60 and C60OH15 molecules disaggregated and monodispersed in the lipid membrane.

sted, utgiver, år, opplag, sider
Springer, 2016. Vol. 18, nr 11
Emneord [en]
Nanoparticles, Carbon materials, Cytotoxicity, Molecular dynamics simulation
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-198573DOI: 10.1007/s11051-016-3647-zISI: 000388221900004OAI: oai:DiVA.org:kth-198573DiVA, id: diva2:1057711
Merknad

QC 20161219

Tilgjengelig fra: 2016-12-19 Laget: 2016-12-19 Sist oppdatert: 2017-11-29bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Søk i DiVA

Av forfatter/redaktør
Liang, Lijun
Av organisasjonen
I samme tidsskrift
Journal of nanoparticle research

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 27 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf