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Systems Biology of Metabolism: A Driver for Developing Personalized and Precision Medicine
KTH, Centra, Science for Life Laboratory, SciLifeLab.
2017 (engelsk)Inngår i: Cell Metabolism, ISSN 1550-4131, E-ISSN 1932-7420, Vol. 25, nr 3, s. 572-579Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Systems biology uses mathematical models to analyze large datasets and simulate system behavior. It enables integrative analysis of different types of data and can thereby provide new insight into complex biological systems. Here will be discussed the challenges of using systems medicine for advancing the development of personalized and precision medicine to treat metabolic diseases like insulin resistance, obesity, NAFLD, NASH, and cancer. It will be illustrated how the concept of genome-scale metabolic models can be used for integrative analysis of big data with the objective of identifying novel biomarkers that are foundational for personalized and precision medicine.

sted, utgiver, år, opplag, sider
CELL PRESS , 2017. Vol. 25, nr 3, s. 572-579
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Identifikatorer
URN: urn:nbn:se:kth:diva-204054DOI: 10.1016/j.cmet.2017.02.002ISI: 000396355700015PubMedID: 28273479Scopus ID: 2-s2.0-85014511212OAI: oai:DiVA.org:kth-204054DiVA, id: diva2:1085735
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QC 20170330

Tilgjengelig fra: 2017-03-30 Laget: 2017-03-30 Sist oppdatert: 2017-11-29bibliografisk kontrollert

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