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Targeted Photodynamic Therapy with a Folate/Sensitizer Assembly Produced from Mesoporous Silica
KTH, Skolan för kemivetenskap (CHE), Kemi, Yt- och korrosionsvetenskap. Nanologica AB, Sweden.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 23, nr 32, s. 7672-7676Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A mesoporous silica material prepared by using folic acid (FA) as a template enables the effective encapsulation of meso-tetrakis(4-carboxyphenyl) porphyrin (TCPP) in its interior. Combination of steady-state and time-resolved absorption and emission spectroscopy demonstrate that FA and TCPP are released from the silica material to the aqueous phase in the form of a non-covalent assembly. This assembly does not form by simple mixing of the two components in the absence of silica, suggesting the key role of the material in the assembling process. The FA/TCPP assembly exhibits dual color fluorescence in the visible region, good photosensitization capability of singlet oxygen, and enhanced photo-induced mortality in KB cancer cells overexpressing folate receptor, if compared with the free components.

sted, utgiver, år, opplag, sider
Wiley-VCH Verlagsgesellschaft, 2017. Vol. 23, nr 32, s. 7672-7676
Emneord [en]
mesoporous silica, photodynamic therapy, singlet oxygen, supramolecular assembly
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-209292DOI: 10.1002/chem.201701432ISI: 000402799200007PubMedID: 28444786Scopus ID: 2-s2.0-85018861535OAI: oai:DiVA.org:kth-209292DiVA, id: diva2:1112452
Forskningsfinansiär
EU, FP7, Seventh Framework Programme, CYCLON-HIT 608407
Merknad

QC 20170620

Tilgjengelig fra: 2017-06-20 Laget: 2017-06-20 Sist oppdatert: 2018-09-19bibliografisk kontrollert

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