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Cellulose nanofibers as excipient for the delivery of poorly soluble drugs
KTH, Skolan för kemivetenskap (CHE), Fiber- och polymerteknologi.
2017 (engelsk)Inngår i: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 533, nr 1, s. 285-297Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Poor aqueous solubility of drugs is becoming an increasingly pronounced challenge in the formulation and development of drug delivery systems. To overcome the limitations associated with these problematic drugs, formulation scientists are required to use enabling strategies which often demands the use of new excipients. Cellulose nanofibers (CNFs) is such an excipient and it has only recently been described in the pharmaceutical field. In this review, the use of CNF in drug formulation with a focus on poorly soluble drugs is featured. In particular, the aim is to describe and discuss the many unique properties of CNFs, which make CNFs attractive as excipients in pharmaceutical sciences. Furthermore, the use of CNF as stabilizers for crystalline drug nanoparticles, as a matrix former to obtain a long-lasting sustained drug release over several weeks and as a film former with immediate release properties for poorly soluble drug are reported. Finally, the preparation of pharmaceutical CNF foams together with poorly soluble drugs is highlighted; foams, which offer a sustained drug delivery system with positive buoyancy.

sted, utgiver, år, opplag, sider
ELSEVIER SCIENCE BV , 2017. Vol. 533, nr 1, s. 285-297
Emneord [en]
Cellulose nanofibers, Drug delivery, Poorly-soluble drugs, Immediate release, Sustained release
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-217402DOI: 10.1016/j.ijpharm.2017.09.064ISI: 000413674200027PubMedID: 28951349Scopus ID: 2-s2.0-85030536371OAI: oai:DiVA.org:kth-217402DiVA, id: diva2:1159081
Merknad

QC 20171121

Tilgjengelig fra: 2017-11-21 Laget: 2017-11-21 Sist oppdatert: 2018-01-13bibliografisk kontrollert

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