Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
On the role of peptide hydrolysis for fibrillation kinetics and amyloid fibril morphology
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Fiber- och polymerteknologi.
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Kemi, Tillämpad fysikalisk kemi.ORCID-id: 0000-0001-9238-7246
2018 (engelsk)Inngår i: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 8, nr 13, s. 6915-6924Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Self-assembly of proteins into amyloid-like nanofibrils is not only a key event in several diseases, but such fibrils are also associated with intriguing biological function and constitute promising components for new biobased materials. The bovine whey protein beta-lactoglobulin has emerged as an important model protein for the development of such materials. We here report that peptide hydrolysis is the rate-determining step for fibrillation of beta-lactoglobulin in whey protein isolate. We also explore the observation that beta-lactoglobulin nanofibrils of distinct morphologies are obtained by simply changing the initial protein concentration. We find that the morphological switch is related to different nucleation mechanisms and that the two classes of nanofibrils are associated with variations of the peptide building blocks. Based on the results, we propose that the balance between protein concentration and the hydrolysis rate determines the structure of the formed nanofibrils.

sted, utgiver, år, opplag, sider
ROYAL SOC CHEMISTRY , 2018. Vol. 8, nr 13, s. 6915-6924
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-224069DOI: 10.1039/c7ra10981dISI: 000425508900022Scopus ID: 2-s2.0-85042187152OAI: oai:DiVA.org:kth-224069DiVA, id: diva2:1190504
Merknad

QC 20180314

Tilgjengelig fra: 2018-03-14 Laget: 2018-03-14 Sist oppdatert: 2018-03-14bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstScopus

Personposter BETA

Hedenqvist, Mikael S.Lendel, Christofer

Søk i DiVA

Av forfatter/redaktør
Ye, XinchenHedenqvist, Mikael S.Lendel, Christofer
Av organisasjonen
I samme tidsskrift
RSC Advances

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 95 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf