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Sexual dimorphism in the width of the mouse synaptonemal complex
KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik. KTH, Centra, Science for Life Laboratory, SciLifeLab.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Journal of Cell Science, ISSN 0021-9533, E-ISSN 1477-9137, Vol. 131, nr 5, artikkel-id jcs212548Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Sexual dimorphism has been used to describe morphological differences between the sexes, but can be extended to any biologically related process that varies between males and females. The synaptonemal complex (SC) is a tripartite structure that connects homologous chromosomes in meiosis. Here, aided by superresolution microscopy techniques, we show that the SC is subject to sexual dimorphism, in mouse germ cells. We have identified a significantly narrower SC in oocytes and have established that this difference does not arise from a different organization of the lateral elements nor from a different isoform of transverse filament protein SYCP1. Instead, we provide evidence for the existence of a narrower central element and a different integration site for the C-termini of SYCP1, in females. In addition to these female-specific features, we speculate that post-translation modifications affecting the SYCP1 coiled-coil region could render a more compact conformation, thus contributing to the narrower SC observed in females.

sted, utgiver, år, opplag, sider
Company of Biologists Ltd , 2018. Vol. 131, nr 5, artikkel-id jcs212548
Emneord [en]
Meiosis, SIM, STORM, Super-resolution microscopy, Synaptonemal complex
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-224822DOI: 10.1242/jcs.212548ISI: 000427877600011Scopus ID: 2-s2.0-85043782610OAI: oai:DiVA.org:kth-224822DiVA, id: diva2:1193293
Forskningsfinansiär
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceSwedish Cancer Society, 170226EU, Horizon 2020, 634113Swedish Research Council, K2013-54X-21397-04-5Swedish Foundation for Strategic Research , RIF14-0091
Merknad

QC 20180326

Tilgjengelig fra: 2018-03-26 Laget: 2018-03-26 Sist oppdatert: 2018-04-11bibliografisk kontrollert

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