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Growth of Cyanobacteria Is Constrained by the Abundance of Light and Carbon Assimilation Proteins
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi. KTH, Centra, Science for Life Laboratory, SciLifeLab. K.
KTH, Skolan för kemi, bioteknologi och hälsa (CBH). KTH, Centra, Science for Life Laboratory, SciLifeLab.
KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Systembiologi. KTH, Centra, Science for Life Laboratory, SciLifeLab.
KTH, Skolan för kemi, bioteknologi och hälsa (CBH). KTH, Centra, Science for Life Laboratory, SciLifeLab.
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2018 (engelsk)Inngår i: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 25, nr 2, s. 478-+Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Cyanobacteria must balance separate demands for energy generation, carbon assimilation, and biomass synthesis. We used shotgun proteomics to investigate proteome allocation strategies in the model cyanobacterium Synechocystis sp. PCC 6803 as it adapted to light and inorganic carbon (C-i) limitation. When partitioning the proteome into seven functional sectors, we find that sector sizes change linearly with growth rate. The sector encompassing ribosomes is significantly smaller than in E. coli, which may explain the lower maximum growth rate in Synechocystis. Limitation of light dramatically affects multiple proteome sectors, whereas the effect of C-i limitation is weak. Carbon assimilation proteins respond more strongly to changes in light intensity than to C-i. A coarse-grained cell economy model generally explains proteome trends. However, deviations from model predictions suggest that the large proteome sectors for carbon and light assimilation are not optimally utilized under some growth conditions and may constrain the proteome space available to ribosomes.

sted, utgiver, år, opplag, sider
et al. , 2018. Vol. 25, nr 2, s. 478-+
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Identifikatorer
URN: urn:nbn:se:kth:diva-237095DOI: 10.1016/j.celrep.2018.09.040ISI: 000446691400020PubMedID: 30304686Scopus ID: 2-s2.0-85054193580OAI: oai:DiVA.org:kth-237095DiVA, id: diva2:1259305
Forskningsfinansiär
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceSwedish Research Council Formas, 2015-939Swedish Research CouncilSwedish Foundation for Strategic Research , RBP14-0013
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QC 20181029

Tilgjengelig fra: 2018-10-29 Laget: 2018-10-29 Sist oppdatert: 2019-10-07bibliografisk kontrollert

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Jahn, MichaelKarlsen, JanMaddalo, GianlucaEdfors, FredrikForsström, BjörnUhlén, MathiasKäll, LukasHudson, Elton P.

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