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Microfluidics for cell factory and bioprocess development
KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Nanobioteknologi.ORCID-id: 0000-0002-3722-5970
KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för kemi, bioteknologi och hälsa (CBH), Proteinvetenskap, Nanobioteknologi.ORCID-id: 0000-0001-5232-0805
2019 (engelsk)Inngår i: Current Opinion in Biotechnology, ISSN 0958-1669, E-ISSN 1879-0429, Vol. 55, s. 95-102Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Bioindustry is expanding to an increasing variety of food, chemical and pharmaceutical products, each requiring rapid development of a dedicated cell factory and bioprocess. Microfluidic tools are, together with tools from synthetic biology and metabolic modeling, being employed in cell factory and bioprocess development to speed up development and address new products. Recent examples of microfluidics for bioprocess development range from integrated devices for DNA assembly and transformation, to high throughput screening of cell factory libraries, and micron scale bioreactors for process optimization. These improvements act to improve the biotechnological engineering cycle with tools for building, testing and evaluating cell factories and bioprocesses by increasing throughput, parallelization and automation.

sted, utgiver, år, opplag, sider
Elsevier, 2019. Vol. 55, s. 95-102
Emneord [en]
Cells, Cytology, Drug products, Microfluidics, Optimization, Bioprocess development, DNA assemblies, High throughput screening, Integrated device, Metabolic modeling, Parallelizations, Pharmaceutical products, Synthetic biology, Cell engineering, bioprocess, biotechnological procedures, cell factory, cell growth, cell population, cell selection, cell separation, priority journal, process optimization, Review, single cell analysis
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Identifikatorer
URN: urn:nbn:se:kth:diva-236324DOI: 10.1016/j.copbio.2018.08.011ISI: 000459949400015Scopus ID: 2-s2.0-85053411311OAI: oai:DiVA.org:kth-236324DiVA, id: diva2:1264401
Forskningsfinansiär
Novo NordiskKnut and Alice Wallenberg FoundationSwedish Research Council Formas
Merknad

QC 20181120

Tilgjengelig fra: 2018-11-20 Laget: 2018-11-20 Sist oppdatert: 2019-09-30

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Björk, SaraJönsson, Håkan

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