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Individualization of Hematopoietic Stem Cell Transplantation Using Alpha/Beta T-Cell Depletion
Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Div Transplantat Surg, Stockholm, Sweden..
Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Div Pediat, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Hematol Immunol HSCT Sect, Stockholm, Sweden..
Karolinska Univ Hosp, Cell Therapy & Allogene Stem Cell Transplantat, Stockholm, Sweden.;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden..
KTH, Centra, Science for Life Laboratory, SciLifeLab. KTH, Skolan för teknikvetenskap (SCI), Tillämpad fysik.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 10, artikkel-id 189Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with several potentially lethal complications. Higher levels of CD3+ T-cells in the graft have been associated with increased risk of graft-versus-host disease (GVHD), but also beneficial graft-versus-leukemia effect and reduced infections. To tackle post-transplant complications, donor lymphocyte infusions have been used but with an increased risk of GVHD. To reduce this risk, we performed depletion of alpha beta T-cells and treated 12 patients post-HSCT suffering from infections and/or poor immune reconstitution. The alpha beta T-cell depleted cell products were characterized by flow cytometry. The median log depletion of alpha beta T-cells was -4.3 and the median yield of gamma delta T-cells was 73.5%. The median CD34+ cell dose was 4.4 x 10(6)/kg. All 12 patients were alive 3 months after infusion and after 1 year, two patients had died. No infusion-related side effects were reported and no severe acute GVHD (grade III-IV) developed in any patient post-infusion. Overall, 3 months after infusion 11 out of 12 patients had increased levels of platelets and/or granulocytes. In conclusion, we describe the use of alpha beta T-cell depleted products as stem cell boosters with encouraging results.

sted, utgiver, år, opplag, sider
FRONTIERS MEDIA SA , 2019. Vol. 10, artikkel-id 189
Emneord [en]
alpha beta T-cell depletion, gamma delta T-cells, allogeneic hematopoietic stem cell transplantation, stem cell booster, donor lymphocyte infusion, graft manipulation, CliniMACS
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-244508DOI: 10.3389/fimmu.2019.00189ISI: 000458248300001Scopus ID: 2-s2.0-85062186448OAI: oai:DiVA.org:kth-244508DiVA, id: diva2:1301495
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QC 20190402

Tilgjengelig fra: 2019-04-02 Laget: 2019-04-02 Sist oppdatert: 2019-04-02bibliografisk kontrollert

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