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A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment
MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Tata Ctr Technol & Design, 77 Massachusetts Ave, Cambridge, MA 02139 USA..
MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA..ORCID-id: 0000-0003-2910-9176
MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Harvard Med Sch, Div Gastroenterol Hepatol & Endoscopy, Brigham & Womens Hosp, Boston, MA 02115 USA..
KTH, Skolan för elektroteknik och datavetenskap (EECS), Mikro- och nanosystemteknik.
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Rekke forfattare: 492019 (engelsk)Inngår i: Science Translational Medicine, ISSN 1946-6234, E-ISSN 1946-6242, Vol. 11, nr 483, artikkel-id eaau6267Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.

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AMER ASSOC ADVANCEMENT SCIENCE , 2019. Vol. 11, nr 483, artikkel-id eaau6267
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URN: urn:nbn:se:kth:diva-251298DOI: 10.1126/scitranslmed.aau6267ISI: 000461050500004PubMedID: 30867322Scopus ID: 2-s2.0-85062832588OAI: oai:DiVA.org:kth-251298DiVA, id: diva2:1314666
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QC 20190509

Tilgjengelig fra: 2019-05-09 Laget: 2019-05-09 Sist oppdatert: 2019-05-09bibliografisk kontrollert

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