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Stenosis Indicators Applied to Patient-Specific Renal Arteries without and with Stenosis
KTH, Skolan för teknikvetenskap (SCI), Centra, BioMEx. KTH, Skolan för teknikvetenskap (SCI), Centra, Linné Flow Center, FLOW. Linköping Univ Hosp, Dept Radiol, SE-58185 Linköping, Sweden.
KTH, Skolan för teknikvetenskap (SCI), Centra, BioMEx. KTH, Skolan för teknikvetenskap (SCI), Centra, Linné Flow Center, FLOW.ORCID-id: 0000-0002-6881-2094
KTH, Skolan för teknikvetenskap (SCI), Centra, Linné Flow Center, FLOW. KTH, Skolan för teknikvetenskap (SCI), Centra, BioMEx.ORCID-id: 0000-0001-9976-8316
2019 (engelsk)Inngår i: FLUIDS, ISSN 2311-5521, Vol. 4, nr 1, artikkel-id 26Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Pulsatile flow in the abdominal aorta and the renal arteries of three patients was studied numerically. Two of the patients had renal artery stenosis. The aim of the study was to assess the use of four types of indicators for determining the risk of new stenosis after revascularization of the affected arteries. The four indicators considered include the time averaged wall shear stress (TAWSS), the oscillatory shear index (OSI), the relative reference time (RRT) and a power law model based in platelet activation modeling but applied to the endothelium, named endothelium activation indicator (EAI). The results show that the indicators can detect the existing stenosis but are less successful in the revascularized cases. The TAWSS and, more clearly, the EAI approach seem to be better in predicting the risk for stenosis relapse at the original location and close to the post-stenotic dilatation. The shortcomings of the respective indicators are discussed along with potential improvements to endothelial activation modeling and its use as an indicator for risks of restenosis.

sted, utgiver, år, opplag, sider
MDPI , 2019. Vol. 4, nr 1, artikkel-id 26
Emneord [en]
renal artery stenosis, blood flow simulation, atherosclerosis, reconstructed arteries, stenosis indicators
HSV kategori
Identifikatorer
URN: urn:nbn:se:kth:diva-251364DOI: 10.3390/fluids4010026ISI: 000464457900001Scopus ID: 2-s2.0-85063386762OAI: oai:DiVA.org:kth-251364DiVA, id: diva2:1315402
Merknad

QC 20190513

Tilgjengelig fra: 2019-05-13 Laget: 2019-05-13 Sist oppdatert: 2019-05-23bibliografisk kontrollert

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